Gene Symbol: PDF1.2
Description: plant defensin 1.2
Alias: LCR77, LOW-MOLECULAR-WEIGHT CYSTEINE-RICH 77, MFC16.8, MFC16_8, PDF1.2A, PLANT DEFENSIN 1.2A, plant defensin 1.2, plant defensin 1.2
Species: thale cress

Top Publications

  1. Penninckx I, Eggermont K, Terras F, Thomma B, De Samblanx G, Buchala A, et al. Pathogen-induced systemic activation of a plant defensin gene in Arabidopsis follows a salicylic acid-independent pathway. Plant Cell. 1996;8:2309-23 pubmed
    ..Our results indicate that systemic pathogen-induced expression of the plant defensin gene in Arabidopsis is independent of salicylic acid but requires components of the ethylene and jasmonic acid response. ..
  2. Manners J, Penninckx I, Vermaere K, Kazan K, Brown R, Morgan A, et al. The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid. Plant Mol Biol. 1998;38:1071-80 pubmed
    ..The transgenic plants containing the PDF1.2-based promoter-reporter construct will provide useful tools for future genetic dissection of this novel systemic signalling pathway. ..
  3. Brown R, Kazan K, McGrath K, Maclean D, Manners J. A role for the GCC-box in jasmonate-mediated activation of the PDF1.2 gene of Arabidopsis. Plant Physiol. 2003;132:1020-32 pubmed
  4. Ahmad S, van Hulten M, Martin J, Pieterse C, van Wees S, Ton J. Genetic dissection of basal defence responsiveness in accessions of Arabidopsis thaliana. Plant Cell Environ. 2011;34:1191-206 pubmed publisher
    ..Our study demonstrates that natural variation in basal resistance can be exploited to identify genetic loci that prime the plant's basal defence arsenal. ..
  5. Epple P, Apel K, Bohlmann H. ESTs reveal a multigene family for plant defensins in Arabidopsis thaliana. FEBS Lett. 1997;400:168-72 pubmed
    ..In seedlings, it is inducible by methyl jasmonate, silver nitrate, and different phytopathogenic fungi, notably Fusarium oxysporum f. sp. matthiolae. The regulation of Pdf1.2 resembles that of the pathogen-inducible thionin gene Thi2.1. ..
  6. Moran P, Thompson G. Molecular responses to aphid feeding in Arabidopsis in relation to plant defense pathways. Plant Physiol. 2001;125:1074-85 pubmed
    ..Phloem feeding on Arabidopsis leads to stimulation of response pathways associated with both pathogen infection and wounding. ..
  7. Cabot C, Gallego B, Martos S, Barceló J, Poschenrieder C. Signal cross talk in Arabidopsis exposed to cadmium, silicon, and Botrytis cinerea. Planta. 2013;237:337-49 pubmed publisher
    ..Taken together, our results provide support for the view that Cd concentrations close to the toxicity threshold induce defence signalling pathways which potentiate the plant's response against fungal infection. ..
  8. Mirouze M, Sels J, Richard O, Czernic P, Loubet S, Jacquier A, et al. A putative novel role for plant defensins: a defensin from the zinc hyper-accumulating plant, Arabidopsis halleri, confers zinc tolerance. Plant J. 2006;47:329-42 pubmed
    ..Our results support the proposition that defensins could be involved in Zn tolerance in A. halleri, and that a role for plant defensins in metal physiology should be considered. ..
  9. Gkizi D, Lehmann S, L Haridon F, Serrano M, Paplomatas E, Métraux J, et al. The Innate Immune Signaling System as a Regulator of Disease Resistance and Induced Systemic Resistance Activity Against Verticillium dahliae. Mol Plant Microbe Interact. 2016;29:313-23 pubmed publisher
    ..2 transcripts in the aerial parts of infected plants treated with strain K165. ..

More Information


  1. Zheng Z, Qamar S, Chen Z, Mengiste T. Arabidopsis WRKY33 transcription factor is required for resistance to necrotrophic fungal pathogens. Plant J. 2006;48:592-605 pubmed
    ..Together, these results indicate that pathogen-induced WRKY33 is an important transcription factor that regulates the antagonistic relationship between defense pathways mediating responses to P. syringae and necrotrophic pathogens. ..
  2. Shin J, Heidrich K, Sánchez Villarreal A, Parker J, Davis S. TIME FOR COFFEE represses accumulation of the MYC2 transcription factor to provide time-of-day regulation of jasmonate signaling in Arabidopsis. Plant Cell. 2012;24:2470-82 pubmed publisher
    ..Taken together, we propose that TIC acts as an output component of the circadian oscillator to influence JA signaling directly. ..
  3. Loehrer M, Langenbach C, Goellner K, Conrath U, Schaffrath U. Characterization of nonhost resistance of Arabidopsis to the Asian soybean rust. Mol Plant Microbe Interact. 2008;21:1421-30 pubmed publisher
    ..Thus, a suppression of P. pachyrhizi-derived effectors by PEN3 can be inferred. Our results demonstrate that Arabidopsis can be used to study mechanisms of NHR to ASR...
  4. Zarei A, Körbes A, Younessi P, Montiel G, Champion A, Memelink J. Two GCC boxes and AP2/ERF-domain transcription factor ORA59 in jasmonate/ethylene-mediated activation of the PDF1.2 promoter in Arabidopsis. Plant Mol Biol. 2011;75:321-31 pubmed publisher
    ..Therefore ORA59 and two functionally equivalent GCC box binding sites form the module that enables the PDF1.2 gene to respond synergistically to simultaneous activation of the JA and ET signaling pathways. ..
  5. He X, Jiang J, Wang C, Dehesh K. ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression. J Integr Plant Biol. 2017;59:275-287 pubmed publisher
    ..These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degradation, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA. ..