Gene Symbol: OZS1
Description: C4-dicarboxylate transporter/malic acid transport protein
Alias: CARBON DIOXIDE INSENSITIVE 3, CDI3, F5O11.23, F5O11_23, OZONE-SENSITIVE 1, RADICAL-INDUCED CELL DEATH 3, RCD3, SLAC1, SLOW ANION CHANNEL-ASSOCIATED 1, C4-dicarboxylate transporter/malic acid transport protein
Species: thale cress

Top Publications

  1. Saji S, Bathula S, Kubo A, Tamaoki M, Kanna M, Aono M, et al. Disruption of a gene encoding C4-dicarboxylate transporter-like protein increases ozone sensitivity through deregulation of the stomatal response in Arabidopsis thaliana. Plant Cell Physiol. 2008;49:2-10 pubmed
    To understand better the plant response to ozone, we isolated and characterized an ozone-sensitive (ozs1) mutant strain from a set of T-DNA-tagged Arabidopsis thaliana ecotype Columbia...
  2. Negi J, Matsuda O, Nagasawa T, Oba Y, Takahashi H, Kawai Yamada M, et al. CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells. Nature. 2008;452:483-6 pubmed publisher
    ..Here we report the isolation of an Arabidopsis gene, SLAC1 (SLOW ANION CHANNEL-ASSOCIATED 1, At1g12480), which mediates CO2 sensitivity in regulation of plant gas exchange...
  3. Geiger D, Scherzer S, Mumm P, Stange A, Marten I, Bauer H, et al. Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair. Proc Natl Acad Sci U S A. 2009;106:21425-30 pubmed publisher
    ..The recently identified guard cell anion channel SLAC1 appeared to be the key ion channel in this signaling pathway but remained electrically silent when expressed ..
  4. Lee S, Lan W, Buchanan B, Luan S. A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A. 2009;106:21419-24 pubmed publisher
    ..conditions, induces stomatal pore closure by activating specific ion channels, such as a slow-anion channel (SLAC1) that, in turn, mediate ion efflux from the guard cells...
  5. Hua D, Wang C, He J, Liao H, Duan Y, Zhu Z, et al. A plasma membrane receptor kinase, GHR1, mediates abscisic acid- and hydrogen peroxide-regulated stomatal movement in Arabidopsis. Plant Cell. 2012;24:2546-61 pubmed publisher
    ..Our study identifies a critical component in ABA and H2O2 signaling that is involved in stomatal movement and resolves a long-standing mystery about the differential functions of ABI1 and ABI2 in this process. ..
  6. Vahisalu T, Kollist H, Wang Y, Nishimura N, Chan W, Valerio G, et al. SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling. Nature. 2008;452:487-91 pubmed publisher
    ..Here we report the mapping and characterization of an ozone-sensitive Arabidopsis thaliana mutant, slac1. We show that SLAC1 (SLOW ANION CHANNEL-ASSOCIATED 1) is preferentially expressed in guard cells and encodes a ..
  7. Laanemets K, Brandt B, Li J, Merilo E, Wang Y, Keshwani M, et al. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiol. 2013;163:504-13 pubmed publisher
  8. Zhang A, Ren H, Tan Y, Qi G, Yao F, Wu G, et al. S-type Anion Channels SLAC1 and SLAH3 Function as Essential Negative Regulators of Inward K+ Channels and Stomatal Opening in Arabidopsis. Plant Cell. 2016;28:949-955 pubmed publisher
    ..However, the underlying molecular mechanism is still largely unknown. Here we show that S-type anion channels SLAC1 and SLAH3 mainly inhibit inward K+ (K+in) channel KAT1 by protein-protein interaction, and consequently prevent ..
  9. Imai H, Noda Y, Tamaoki M. Alteration of Arabidopsis SLAC1 promoter and its association with natural variation in drought tolerance. Plant Signal Behav. 2015;10:e989761 pubmed publisher
    ..Surveying in the locus, we extrapolated that the SLAC1 gene, which is associated with stomatal closure, was likely responsible for the difference of drought tolerance...

More Information


  1. Du Q, Fan X, Wang C, Huang R. A possible CO2 conducting and concentrating mechanism in plant stomata SLAC1 channel. PLoS ONE. 2011;6:e24264 pubmed publisher
    The plant SLAC1 is a slow anion channel in the membrane of stomatal guard cells, which controls the turgor pressure in the aperture-defining guard cells, thereby regulating the exchange of water vapour and photosynthetic gases in ..
  2. Geiger D, Scherzer S, Mumm P, Marten I, Ache P, Matschi S, et al. Guard cell anion channel SLAC1 is regulated by CDPK protein kinases with distinct Ca2+ affinities. Proc Natl Acad Sci U S A. 2010;107:8023-8 pubmed publisher
    ..Recently, the guard cell anion channel SLAC1 was identified. When expressed heterologously SLAC1 remained electrically silent...
  3. Laanemets K, Wang Y, Lindgren O, Wu J, Nishimura N, Lee S, et al. Mutations in the SLAC1 anion channel slow stomatal opening and severely reduce K+ uptake channel activity via enhanced cytosolic [Ca2+] and increased Ca2+ sensitivity of K+ uptake channels. New Phytol. 2013;197:88-98 pubmed publisher
    The Arabidopsis guard cell anion channel SLAC1 is essential for stomatal closure in response to various endogenous and environmental stimuli. Interestingly, here we reveal an unexpected impairment of slac1 alleles on stomatal opening...
  4. Joudoi T, Shichiri Y, Kamizono N, Akaike T, Sawa T, Yoshitake J, et al. Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis. Plant Cell. 2013;25:558-71 pubmed publisher
    ..This study therefore demonstrates that 8-nitro-cGMP acts as a guard cell signaling molecule and that a NO/8-nitro-cGMP signaling cascade operates in guard cells. ..
  5. Tian W, Hou C, Ren Z, Pan Y, Jia J, Zhang H, et al. A molecular pathway for COâ‚‚ response in Arabidopsis guard cells. Nat Commun. 2015;6:6057 pubmed publisher
    ..We also show that HT1 phosphorylates and inactivates OST1, a kinase which is essential for the activation of the SLAC1 anion channel and stomatal closing...
  6. Vahisalu T, Puzõrjova I, Brosché M, Valk E, Lepiku M, Moldau H, et al. Ozone-triggered rapid stomatal response involves the production of reactive oxygen species, and is controlled by SLAC1 and OST1. Plant J. 2010;62:442-53 pubmed publisher
    ..This revealed that the SLAC1 protein, essential for guard cell plasma membrane S-type anion channel function, and the protein kinase OST1 were ..
  7. Lee S, Lim C, Lan W, He K, Luan S. ABA signaling in guard cells entails a dynamic protein-protein interaction relay from the PYL-RCAR family receptors to ion channels. Mol Plant. 2013;6:528-38 pubmed publisher
    ..We previously reported that SLAC1, an outward anion channel required for stomatal closure, was regulated via reversible protein phosphorylation ..
  8. Wang Y, Papanatsiou M, Eisenach C, Karnik R, Williams M, Hills A, et al. Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration. Plant Physiol. 2012;160:1956-67 pubmed publisher
    ..the paradoxical suppression of channels that facilitate K(+) uptake, slowing stomatal opening, by mutation of the SLAC1 anion channel, which mediates solute loss for closure...
  9. Merilo E, Laanemets K, Hu H, Xue S, Jakobson L, Tulva I, et al. PYR/RCAR receptors contribute to ozone-, reduced air humidity-, darkness-, and CO2-induced stomatal regulation. Plant Physiol. 2013;162:1652-68 pubmed publisher
    ..reduction of air humidity, darkness, and pulses of the air pollutant ozone (O3), involves the SLOW ANION CHANNEL1 (SLAC1). SLAC1 is activated by OPEN STOMATA1 (OST1) and Ca(2+)-dependent protein kinases...