Gene Symbol: OEP80
Description: outer envelope protein of 80 kDa
Alias: ARABIDOPSIS THALIANA OUTER ENVELOPE PROTEIN OF 80 KDA, ATOEP80, EMB213, EMBRYO DEFECTIVE 213, T29J13.40, T29J13_40, TOC75, TOC75-V, outer envelope protein of 80 kDa, translocon at the outer envelope membrane of chloroplasts 75-V, outer envelope protein of 80 kDa
Species: thale cress

Top Publications

  1. Hsu S, Nafati M, Inoue K. OEP80, an essential protein paralogous to the chloroplast protein translocation channel Toc75, exists as a 70-kD protein in the Arabidopsis thaliana chloroplast outer envelope. Plant Mol Biol. 2012;78:147-58 pubmed publisher
    b>Toc75 and OEP80 are paralogous proteins found in the Viridiplantae lineages, and appear to have evolved from a protein in the outer membrane of an ancient cyanobacterium...
  2. Inoue H, Li M, Schnell D. An essential role for chloroplast heat shock protein 90 (Hsp90C) in protein import into chloroplasts. Proc Natl Acad Sci U S A. 2013;110:3173-8 pubmed publisher
    ..Hsp90C was specifically coprecipitated with a complex of protein import components, including Tic110, Tic40, Toc75, Tic22, and the stromal chaperones, Hsp93 and Hsp70...
  3. Inoue K, Potter D. The chloroplastic protein translocation channel Toc75 and its paralog OEP80 represent two distinct protein families and are targeted to the chloroplastic outer envelope by different mechanisms. Plant J. 2004;39:354-65 pubmed
    ..First, we found that the native molecular weight of atToc75-V is 80 kDa and renamed it (AtOEP80) Arabidopsis thalianaouter envelope protein of 80 kDa...
  4. Ling Q, Huang W, Baldwin A, Jarvis P. Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system. Science. 2012;338:655-9 pubmed publisher
    ..Thus, the ubiquitin-proteasome system acts on plastids to control their development. ..
  5. Huang J, Taylor J, Chen J, Uhrig J, Schnell D, Nakagawa T, et al. The plastid protein THYLAKOID FORMATION1 and the plasma membrane G-protein GPA1 interact in a novel sugar-signaling mechanism in Arabidopsis. Plant Cell. 2006;18:1226-38 pubmed
    ..The interaction between THF1 and GPA1 has been confirmed by in vitro and in vivo coimmunoprecipitation, FRET analysis, and genetic epistasis and provides evidence of a sugar-signaling mechanism between plastids and the plasma membrane. ..
  6. Huang W, Ling Q, Bédard J, Lilley K, Jarvis P. In vivo analyses of the roles of essential Omp85-related proteins in the chloroplast outer envelope membrane. Plant Physiol. 2011;157:147-59 pubmed publisher
    ..membrane of chloroplasts, 75 kD), encoded by atTOC75-III; and OEP80 (Outer Envelope Protein, 80 kD), encoded by AtOEP80/atTOC75-V...
  7. Paila Y, Richardson L, Inoue H, Parks E, McMahon J, Inoue K, et al. Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import. elife. 2016;5: pubmed publisher
    b>Toc75 plays a central role in chloroplast biogenesis in plants as the membrane channel of the protein import translocon at the outer envelope of chloroplasts (TOC)...
  8. Chou M, Fitzpatrick L, Tu S, Budziszewski G, Potter Lewis S, Akita M, et al. Tic40, a membrane-anchored co-chaperone homolog in the chloroplast protein translocon. EMBO J. 2003;22:2970-80 pubmed
    ..We propose that Tic40 functions as a co-chaperone in the stromal chaperone complex that facilitates protein translocation across the inner membrane. ..
  9. Wallas T, Smith M, Sanchez Nieto S, Schnell D. The roles of toc34 and toc75 in targeting the toc159 preprotein receptor to chloroplasts. J Biol Chem. 2003;278:44289-97 pubmed
    ..The core of the Toc complex is composed of two receptor GTPases, Toc159 and Toc34, as well as Toc75, a beta-barrel membrane channel...

More Information


  1. Reinbothe C, Bartsch S, Eggink L, Hoober J, Brusslan J, Andrade Paz R, et al. A role for chlorophyllide a oxygenase in the regulated import and stabilization of light-harvesting chlorophyll a/b proteins. Proc Natl Acad Sci U S A. 2006;103:4777-82 pubmed
    ..Together, our results provide insights into the plastid subcompartmentalization and evolution of chlorophyll precursor biosynthesis in relation to protein import in higher plants. ..
  2. Patel R, Hsu S, Bédard J, Inoue K, Jarvis P. The Omp85-related chloroplast outer envelope protein OEP80 is essential for viability in Arabidopsis. Plant Physiol. 2008;148:235-45 pubmed publisher
    ..We characterized three T-DNA mutants of the Arabidopsis OEP80 (AtOEP80) gene...