Gene Symbol: NUDT7
Description: MutT/nudix family protein
Alias: ATNUDX7, Arabidopsis thaliana Nudix hydrolase homolog 7, AtNUDT7, GFG1, GROWTH FACTOR GENE 1, T20K18.70, T20K18_70, MutT/nudix family protein
Species: thale cress

Top Publications

  1. Jambunathan N, Mahalingam R. Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling. Planta. 2006;224:1-11 pubmed
    ..We demonstrate that Arabidopsis Growth Factor Gene 1 (GFG1; At4g12720) encoding a nudix hydrolase, is an NADH pyrophosphatase and ADP-ribose pyrophosphatase...
  2. Olejnik K, PÅ‚ochocka D, Grynberg M, Goch G, Gruszecki W, Basinska T, et al. Mutational analysis of the AtNUDT7 Nudix hydrolase from Arabidopsis thaliana reveals residues required for protein quaternary structure formation and activity. Acta Biochim Pol. 2009;56:291-300 pubmed
    Arabidopsis thaliana AtNUDT7, a homodimeric Nudix hydrolase active on ADP-ribose and NADH, exerts negative control on the major signaling complex involved in plant defense activation and programmed cell death...
  3. Ishikawa K, Ogawa T, Hirosue E, Nakayama Y, Harada K, Fukusaki E, et al. Modulation of the poly(ADP-ribosyl)ation reaction via the Arabidopsis ADP-ribose/NADH pyrophosphohydrolase, AtNUDX7, is involved in the response to oxidative stress. Plant Physiol. 2009;151:741-54 pubmed publisher
    ..PAR) reaction by an Arabidopsis (Arabidopsis thaliana) ADP-ribose (Rib)/NADH pyrophosphohydrolase, AtNUDX7 (for Arabidopsis Nudix hydrolase 7), in AtNUDX7-overexpressed (Pro(35S):AtNUDX7) or AtNUDX7-disrupted (KO-nudx7) ..
  4. Ogawa T, Ueda Y, Yoshimura K, Shigeoka S. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. J Biol Chem. 2005;280:25277-83 pubmed
    ..coli MutT in A. thaliana and is involved in the prevention of spontaneous mutation. The results obtained here suggest that the plant Nudix family has evolved in a specific manner that differs from that of yeast and humans. ..
  5. Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze J, Bautor J, et al. Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell. 2006;18:1038-51 pubmed
    ..FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) positively regulates the EDS1 pathway, and one member (NUDT7) of a family of cytosolic Nudix hydrolases exerts negative control of EDS1 signaling...
  6. Adams Phillips L, Wan J, Tan X, Dunning F, Meyers B, Michelmore R, et al. Discovery of ADP-ribosylation and other plant defense pathway elements through expression profiling of four different Arabidopsis-Pseudomonas R-avr interactions. Mol Plant Microbe Interact. 2008;21:646-57 pubmed publisher plant defense responses was suggested initially by the upregulated expression of genes encoding NUDT7 and poly(ADP-ribose) glycohydrolase in multiple R-avr interactions...
  7. Ge X, Li G, Wang S, Zhu H, Zhu T, Wang X, et al. AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis. Plant Physiol. 2007;145:204-15 pubmed
    ..b>AtNUDT7, a Nudix domain-containing protein in Arabidopsis (Arabidopsis thaliana) that hydrolyzes nucleotide derivatives, ..
  8. Olejnik K, Kraszewska E. Cloning and characterization of an Arabidopsis thaliana Nudix hydrolase homologous to the mammalian GFG protein. Biochim Biophys Acta. 2005;1752:133-41 pubmed
    ..2 mM and 2.7 s(-1) respectively. The products of ADP-ribose hydrolysis were AMP and ribose-5-phosphate. The optimal activity was at alkaline pH (8.5) with Mg2+ (5 mM) ions as the cofactor. The protein exists as a dimmer in solution. ..
  9. Olejnik K, Bucholc M, Anielska Mazur A, Lipko A, Kujawa M, Modzelan M, et al. Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. Acta Biochim Pol. 2011;58:609-16 pubmed
    Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses...

More Information


  1. Zeng X, Li Y, Mahalingam R. Arabidopsis nudix hydrolase 7 plays a role in seed germination. Planta. 2014;239:1015-25 pubmed publisher
    Arabidopsis nudix hydrolase 7 (Atnudt7) mutants exhibit reduced seed germination phenotype following after-ripening. The role of AtNUDT7 in seeds and during early stages of imbibition was examined...
  2. Muthuramalingam M, Zeng X, Iyer N, Klein P, Mahalingam R. A GCC-box motif in the promoter of nudix hydrolase 7 (AtNUDT7) gene plays a role in ozone response of Arabidopsis ecotypes. Genomics. 2015;105:31-8 pubmed publisher
    Arabidopsis nudix hydrolase 7 (AtNudt7) plays an important role in regulating redox homeostasis during stress/defense signaling and seed germination...
  3. Ogawa T, Muramoto K, Takada R, Nakagawa S, Shigeoka S, Yoshimura K. Modulation of NADH Levels by Arabidopsis Nudix Hydrolases, AtNUDX6 and 7, and the Respective Proteins Themselves Play Distinct Roles in the Regulation of Various Cellular Responses Involved in Biotic/Abiotic Stresses. Plant Cell Physiol. 2016;57:1295-308 pubmed publisher
    ..thioredoxin-h5, the activator of NPR1 and SA-induced NPR1-dependent defense genes, while the active and inactive AtNUDX7 proteins suppressed the accumulation of SA and subsequent gene expression, indicating that AtNUDX6 and 7 proteins ..
  4. Jambunathan N, Penaganti A, Tang Y, Mahalingam R. Modulation of redox homeostasis under suboptimal conditions by Arabidopsis nudix hydrolase 7. BMC Plant Biol. 2010;10:173 pubmed publisher
    ..Several independent studies have demonstrated that Arabidopsis nudix hydrolase 7 (AtNUDT7) hydrolyzes NADH and ADP-ribose...
  5. Mu oz F, Baroja Fern ndez E, Mor n Zorzano M, Alonso Casaj s N, Pozueta Romero J. Cloning, expression and characterization of a Nudix hydrolase that catalyzes the hydrolytic breakdown of ADP-glucose linked to starch biosynthesis in Arabidopsis thaliana. Plant Cell Physiol. 2006;47:926-34 pubmed publisher
    ..The overall information provides the first evidence for the existence of plant Nudix hydrolases that have access to an intracellular pool of ADP-glucose linked to starch biosynthesis...