Gene Symbol: NRPE7
Description: RNA polymerase Rpb7-like, N-terminal domain-containing protein
Alias: DL3370C, FCAALL.283, RNA polymerase Rpb7-like, N-terminal domain-containing protein
Species: thale cress
Ream T, Haag J, Wierzbicki A, Nicora C, Norbeck A, Zhu J, et al
. Subunit compositions of the RNA-silencing enzymes Pol IV and Pol V reveal their origins as specialized forms of RNA polymerase II. Mol Cell. 2009;33:192-203 pubmed publisher
..Our findings support the hypothesis that Pol IV and Pol V are Pol II-like enzymes that evolved specialized roles in the production of noncoding transcripts for RNA silencing and genome defense. ..
Law J, Ausin I, Johnson L, Vashisht A, Zhu J, Wohlschlegel J, et al
. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol. 2010;20:951-6 pubmed publisher
..These results suggest that the DDR complex acts in RdDM at a step upstream of the recruitment or activation of Pol V. ..
Law J, Vashisht A, Wohlschlegel J, Jacobsen S. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet. 2011;7:e1002195 pubmed publisher
Zheng Q, Rowley M, Böhmdorfer G, Sandhu D, Gregory B, Wierzbicki A. RNA polymerase V targets transcriptional silencing components to promoters of protein-coding genes. Plant J. 2013;73:179-89 pubmed publisher
..Based on these findings, we propose that the targets of AGO4-directed RdDM are regulatory units responsible for controlling gene expression under specific environmental conditions. ..
Zhong X, Hale C, Nguyen M, Ausin I, Groth M, Hetzel J, et al
. Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis. Proc Natl Acad Sci U S A. 2015;112:911-6 pubmed publisher
..This work sheds further light on the mechanism by which long noncoding RNAs facilitate RNA-directed DNA methylation. ..