NRPE5

Summary

Gene Symbol: NRPE5
Description: Eukaryotic rpb5 RNA polymerase subunit family protein
Alias: RNA POLYMERASE II FIFTH LARGEST SUBUNIT, RPB5B, Eukaryotic rpb5 RNA polymerase subunit family protein
Species: thale cress

Top Publications

  1. Lahmy S, Pontier D, Cavel E, Vega D, El Shami M, Kanno T, et al. PolV(PolIVb) function in RNA-directed DNA methylation requires the conserved active site and an additional plant-specific subunit. Proc Natl Acad Sci U S A. 2009;106:941-6 pubmed publisher
  2. Zhong X, Hale C, Nguyen M, Ausin I, Groth M, Hetzel J, et al. Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis. Proc Natl Acad Sci U S A. 2015;112:911-6 pubmed publisher
    ..This work sheds further light on the mechanism by which long noncoding RNAs facilitate RNA-directed DNA methylation. ..
  3. Ream T, Haag J, Wierzbicki A, Nicora C, Norbeck A, Zhu J, et al. Subunit compositions of the RNA-silencing enzymes Pol IV and Pol V reveal their origins as specialized forms of RNA polymerase II. Mol Cell. 2009;33:192-203 pubmed publisher
    ..Our findings support the hypothesis that Pol IV and Pol V are Pol II-like enzymes that evolved specialized roles in the production of noncoding transcripts for RNA silencing and genome defense. ..
  4. Law J, Ausin I, Johnson L, Vashisht A, Zhu J, Wohlschlegel J, et al. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol. 2010;20:951-6 pubmed publisher
    ..These results suggest that the DDR complex acts in RdDM at a step upstream of the recruitment or activation of Pol V. ..