Gene Symbol: NRPB9A
Description: RNA polymerases M/15 Kd subunit
Alias: NRPD9A, NRPE9A, RNA polymerases M/15 Kd subunit
Species: thale cress
Law J, Ausin I, Johnson L, Vashisht A, Zhu J, Wohlschlegel J, et al
. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol. 2010;20:951-6 pubmed publisher
..These results suggest that the DDR complex acts in RdDM at a step upstream of the recruitment or activation of Pol V. ..
Ream T, Haag J, Wierzbicki A, Nicora C, Norbeck A, Zhu J, et al
. Subunit compositions of the RNA-silencing enzymes Pol IV and Pol V reveal their origins as specialized forms of RNA polymerase II. Mol Cell. 2009;33:192-203 pubmed publisher
..Our findings support the hypothesis that Pol IV and Pol V are Pol II-like enzymes that evolved specialized roles in the production of noncoding transcripts for RNA silencing and genome defense. ..
Zhong X, Hale C, Nguyen M, Ausin I, Groth M, Hetzel J, et al
. Domains rearranged methyltransferase3 controls DNA methylation and regulates RNA polymerase V transcript abundance in Arabidopsis. Proc Natl Acad Sci U S A. 2015;112:911-6 pubmed publisher
..This work sheds further light on the mechanism by which long noncoding RNAs facilitate RNA-directed DNA methylation. ..
Law J, Vashisht A, Wohlschlegel J, Jacobsen S. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet. 2011;7:e1002195 pubmed publisher
Tan E, Blevins T, Ream T, Pikaard C. Functional consequences of subunit diversity in RNA polymerases II and V. Cell Rep. 2012;1:208-14 pubmed
..Collectively, our results reveal a role for the ninth subunit in RNA silencing and demonstrate that subunit diversity generates functionally distinct subtypes of RNA polymerases II and V. ..