Gene Symbol: MSI1
Description: Transducin/WD40 repeat-like superfamily protein
Species: thale cress

Top Publications

  1. Hennig L, Taranto P, Walser M, Schonrock N, Gruissem W. Arabidopsis MSI1 is required for epigenetic maintenance of reproductive development. Development. 2003;130:2555-65 pubmed
    ..We constructed Arabidopsis plants in which the AtMSI1 protein level was altered...
  2. Calonje M, Sanchez R, Chen L, Sung Z. EMBRYONIC FLOWER1 participates in polycomb group-mediated AG gene silencing in Arabidopsis. Plant Cell. 2008;20:277-91 pubmed publisher
    ..Our data indicate that EMF1 plays a PRC1-like role in the PcG-mediated floral repression mechanism. ..
  3. Jullien P, Mosquna A, Ingouff M, Sakata T, Ohad N, Berger F. Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis. PLoS Biol. 2008;6:e194 pubmed publisher
    ..We have thus identified a new mechanism required for imprinting establishment, outlining a new role for the Retinoblastoma pathway, which may be conserved in mammals. ..
  4. Kohler C, Hennig L, Bouveret R, Gheyselinck J, Grossniklaus U, Gruissem W. Arabidopsis MSI1 is a component of the MEA/FIE Polycomb group complex and required for seed development. EMBO J. 2003;22:4804-14 pubmed
    ..Here we show that the Arabidopsis WD-40 domain protein MSI1 is present together with MEA and FIE in a 600 kDa complex and interacts directly with FIE...
  5. Ingouff M, Jullien P, Berger F. The female gametophyte and the endosperm control cell proliferation and differentiation of the seed coat in Arabidopsis. Plant Cell. 2006;18:3491-501 pubmed
    ..seed coat occur in autonomous seeds produced in the absence of fertilization of the multicopy suppressor of ira1 (msi1) mutant...
  6. Chen Z, Tan J, Ingouff M, Sundaresan V, Berger F. Chromatin assembly factor 1 regulates the cell cycle but not cell fate during male gametogenesis in Arabidopsis thaliana. Development. 2008;135:65-73 pubmed
    ..The single sperm is functional and fertilizes indiscriminately either female gamete. Our results thus suggest that pollen cell fate is independent from cell cycle regulation. ..
  7. Rodrigues J, Tucker M, Johnson S, Hrmova M, Koltunow A. Sexual and apomictic seed formation in Hieracium requires the plant polycomb-group gene FERTILIZATION INDEPENDENT ENDOSPERM. Plant Cell. 2008;20:2372-86 pubmed publisher
    ..These differences in protein interaction were attributed to structural modifications predicted from comparisons of Arabidopsis and Hieracium FIE molecular models. ..
  8. Schonrock N, Exner V, Probst A, Gruissem W, Hennig L. Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana. J Biol Chem. 2006;281:9560-8 pubmed
  9. Leroy O, Hennig L, Breuninger H, Laux T, Kohler C. Polycomb group proteins function in the female gametophyte to determine seed development in plants. Development. 2007;134:3639-48 pubmed
    ..We tested in Arabidopsis whether the parent-of-origin-dependent seed abortion caused by lack of the FIS subunit MSI1 is caused by parental imprinting of the MSI1 gene...

More Information


  1. Derkacheva M, Steinbach Y, Wildhaber T, Mozgová I, Mahrez W, Nanni P, et al. Arabidopsis MSI1 connects LHP1 to PRC2 complexes. EMBO J. 2013;32:2073-85 pubmed publisher
    ..This work established the fact that all known plant PRC2 complexes contain MSI1, a homologue of Drosophila p55...
  2. Bouveret R, Schonrock N, Gruissem W, Hennig L. Regulation of flowering time by Arabidopsis MSI1. Development. 2006;133:1693-702 pubmed
    The transition to flowering is tightly controlled by endogenous programs and environmental signals. We found that MSI1 is a novel flowering-time gene in Arabidopsis...
  3. Liang S, Hartwig B, Perera P, Mora García S, de Leau E, Thornton H, et al. Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2. PLoS Genet. 2015;11:e1005660 pubmed publisher
  4. De Lucia F, Crevillen P, Jones A, Greb T, Dean C. A PHD-polycomb repressive complex 2 triggers the epigenetic silencing of FLC during vernalization. Proc Natl Acad Sci U S A. 2008;105:16831-6 pubmed publisher
    ..complex forms composed of core PRC2 components (VRN2, SWINGER [an E(Z) HMTase homologue], FIE [an ESC homologue], MSI1 [p55 homologue]), and three related PHD finger proteins, VRN5, VIN3, and VEL1...
  5. Exner V, Taranto P, Schonrock N, Gruissem W, Hennig L. Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development. Development. 2006;133:4163-72 pubmed
    ..Biochemical evidence suggests that FASCIATA1, FASCIATA2 and MSI1 form CAF-1 in Arabidopsis thaliana...
  6. Mehdi S, Derkacheva M, Ramström M, Kralemann L, Bergquist J, Hennig L. The WD40 Domain Protein MSI1 Functions in a Histone Deacetylase Complex to Fine-Tune Abscisic Acid Signaling. Plant Cell. 2016;28:42-54 pubmed publisher
    b>MSI1 belongs to a family of histone binding WD40-repeat proteins. Arabidopsis thaliana contains five genes encoding MSI1-like proteins, but their functions in diverse chromatin-associated complexes are poorly understood...
  7. Alexandre C, Möller Steinbach Y, Schonrock N, Gruissem W, Hennig L. Arabidopsis MSI1 is required for negative regulation of the response to drought stress. Mol Plant. 2009;2:675-687 pubmed publisher
    Arabidopsis MSI1 has fundamental functions in plant development. MSI1 is a subunit of Polycomb group protein complexes and Chromatin assembly factor 1, and it interacts with the Retinoblastoma-related protein 1...
  8. Dumbliauskas E, Lechner E, Jaciubek M, Berr A, Pazhouhandeh M, Alioua M, et al. The Arabidopsis CUL4-DDB1 complex interacts with MSI1 and is required to maintain MEDEA parental imprinting. EMBO J. 2011;30:731-43 pubmed publisher
    ..Among putative CRL4 receptors we identified MULTICOPY SUPPRESSOR OF IRA1 (MSI1), which belongs to an evolutionary conserved protein family...