Gene Symbol: MOM
Description: ATP-dependent helicase family protein
Alias: MAINTENANCE OF METHYLATION, MOM1, MORPHEUS MOLECULE, MORPHEUS MOLECULE 1, T6D22.14, T6D22_14, ATP-dependent helicase family protein
Species: thale cress

Top Publications

  1. Amedeo P, Habu Y, Afsar K, Mittelsten Scheid O, Paszkowski J. Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Nature. 2000;405:203-6 pubmed
    ..We have isolated an Arabidopsis gene, MOM, whose product is required for the maintenance of transcriptional gene silencing...
  2. Habu Y, Mathieu O, Tariq M, Probst A, Smathajitt C, Zhu T, et al. Epigenetic regulation of transcription in intermediate heterochromatin. EMBO Rep. 2006;7:1279-84 pubmed
    ..In mom1 (Morpheus' molecule 1) mutants, however, a marked increase in transcription is not accompanied by detectable ..
  3. Caikovski M, Yokthongwattana C, Habu Y, Nishimura T, Mathieu O, Paszkowski J. Divergent evolution of CHD3 proteins resulted in MOM1 refining epigenetic control in vascular plants. PLoS Genet. 2008;4:e1000165 pubmed publisher
    Arabidopsis MOM1 is required for the heritable maintenance of transcriptional gene silencing (TGS)...
  4. Yokthongwattana C, Bucher E, Caikovski M, Vaillant I, Nicolet J, Mittelsten Scheid O, et al. MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing. EMBO J. 2010;29:340-51 pubmed publisher
    ..The TGS regulator MOM1 in Arabidopsis is exceptional since it regulates transcription in intermediate heterochromatin with only minor ..
  5. Zhou Y, Zhang J, Lin H, Guo G, Guo Y. MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant Physiol. 2010;154:1272-80 pubmed publisher
    ..In this study, we found that MORPHEUS' MOLECULE1 (MOM1) is a key component of this regulatory machinery...
  6. Habu Y. Epigenetic silencing of endogenous repetitive sequences by MORPHEUS' MOLECULE1 in Arabidopsis thaliana. Epigenetics. 2010;5:562-5 pubmed publisher
    Morpheus' molecule1 (MOM1) is a plant-specific epigenetic regulator of transcriptional gene silencing...
  7. Petty T, Nishimura T, Emamzadah S, Gabus C, Paszkowski J, Halazonetis T, et al. Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:916-8 pubmed publisher
    Of the known epigenetic control regulators found in plants, the Morpheus' molecule 1 (MOM1) protein is atypical in that the deletion of MOM1 does not affect the level of epigenetic marks controlling the transcriptional status of the ..
  8. Elrouby N, Bonequi M, Porri A, Coupland G. Identification of Arabidopsis SUMO-interacting proteins that regulate chromatin activity and developmental transitions. Proc Natl Acad Sci U S A. 2013;110:19956-61 pubmed publisher
    ..It reduces protein levels of CYCLING DOF FACTOR 2, hence increasing transcript levels of CONSTANS and promoting flowering through the photoperiodic pathway. ..
  9. Moissiard G, Bischof S, Husmann D, Pastor W, Hale C, Yen L, et al. Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers. Proc Natl Acad Sci U S A. 2014;111:7474-9 pubmed publisher
    ..In Arabidopsis, mutation of Morpheus Molecule 1 (MOM1) causes transcriptional derepression of heterochromatin independently of changes in DNA methylation...

More Information


  1. Iwasaki M, Paszkowski J. Identification of genes preventing transgenerational transmission of stress-induced epigenetic states. Proc Natl Acad Sci U S A. 2014;111:8547-52 pubmed publisher
    ..silencing and found that two chromatin regulators, Decrease in DNA methylation1 (DDM1) and Morpheus' Molecule1 (MOM1), act redundantly to restore prestress state and thus erase "epigenetic stress memory"...
  2. Han Y, Zhao Q, Dang L, Luo Y, Chen S, Shao C, et al. The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing. Plant Cell. 2016;28:1215-29 pubmed publisher
    The mechanism by which MORPHEUS' MOLECULE1 (MOM1) contributes to transcriptional gene silencing has remained elusive since the gene was first identified and characterized...
  3. Nishimura T, Molinard G, Petty T, Broger L, Gabus C, Halazonetis T, et al. Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. PLoS Genet. 2012;8:e1002484 pubmed publisher
    ..b>MOM1, a protein of 2,001 amino acids that acts as a transcriptional silencer, represents such an exception...