Gene Symbol: MKK5
Description: MAP kinase kinase 5
Species: thale cress

Top Publications

  1. Asai T, Tena G, Plotnikova J, Willmann M, Chiu W, Gomez Gomez L, et al. MAP kinase signalling cascade in Arabidopsis innate immunity. Nature. 2002;415:977-83 pubmed
    ..Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a ..
  2. Wang H, Ngwenyama N, Liu Y, Walker J, Zhang S. Stomatal development and patterning are regulated by environmentally responsive mitogen-activated protein kinases in Arabidopsis. Plant Cell. 2007;19:63-73 pubmed
    ..two environmentally responsive mitogen-activated protein kinases (MAPKs), and their upstream MAPK kinases, MKK4 and MKK5, are key regulators of stomatal development and patterning...
  3. Meng X, Wang H, He Y, Liu Y, Walker J, Torii K, et al. A MAPK cascade downstream of ERECTA receptor-like protein kinase regulates Arabidopsis inflorescence architecture by promoting localized cell proliferation. Plant Cell. 2012;24:4948-60 pubmed publisher
    ..Similar to an er mutant, loss of function of MPK3/MPK6 or their upstream MAPK kinases (MAPKKs; or MKKs), MKK4/MKK5, resulted in shortened pedicels and clustered inflorescences...
  4. Miles G, Samuel M, Ellis B. Suppression of MKK5 reduces ozone-induced signal transmission to both MPK3 and MPK6 and confers increased ozone sensitivity in Arabidopsis thaliana. Plant Signal Behav. 2009;4:687-92 pubmed
    ..involved in the activation of these specific MAPKs, we employed RNA interference-(RNAi)-based suppression of MKK5, a known cognate MAPKK to both MPK3 and MPK6...
  5. Xing Y, Chen W, Jia W, Zhang J. Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress. J Exp Bot. 2015;66:5971-81 pubmed publisher
    ..FSD2 and FSD3, was significantly increased in Arabidopsis in response to NaCl treatment but blocked in transgenic MKK5-RNAi plant, mkk5...
  6. Lee H, Back K. Mitogen-activated protein kinase pathways are required for melatonin-mediated defense responses in plants. J Pineal Res. 2016;60:327-35 pubmed publisher
    ..Using an array of MAP kinase kinase (MKK) knockout mutants, we found that four MKKs, namely MKK4, MKK5, MKK7, and MKK9, are responsible for the activation of MPK3 and MPK6 by melatonin, indicating that melatonin-..
  7. Khan M, Rozhon W, Bigeard J, Pflieger D, Husar S, Pitzschke A, et al. Brassinosteroid-regulated GSK3/Shaggy-like kinases phosphorylate mitogen-activated protein (MAP) kinase kinases, which control stomata development in Arabidopsis thaliana. J Biol Chem. 2013;288:7519-27 pubmed publisher
    ..and its homologues, GSK3/Shaggy-like kinases involved in BR signaling, can phosphorylate the MAPK kinases MKK4 and MKK5, which are members of the MAPK module YODA-MKK4/5-MPK3/6 that controls stomata development and patterning...
  8. Cheng Z, Li J, Niu Y, Zhang X, Woody O, Xiong Y, et al. Pathogen-secreted proteases activate a novel plant immune pathway. Nature. 2015;521:213-6 pubmed publisher
    ..The ability of P. aeruginosa to infect both plants and animals makes it an excellent model to identify novel immunoregulatory strategies that account for its niche adaptation to diverse host tissues and immune systems. ..
  9. Xing Y, Cao Q, Zhang Q, Qin L, Jia W, Zhang J. MKK5 regulates high light-induced gene expression of Cu/Zn superoxide dismutase 1 and 2 in Arabidopsis. Plant Cell Physiol. 2013;54:1217-27 pubmed publisher
    ..Here, we report that MKK5, a mitogen-activated protein kinase kinase, mediated the high light-induced expression of genes of two copper/zinc ..

More Information


  1. Li K, Yang F, Zhang G, Song S, Li Y, Ren D, et al. AIK1, A Mitogen-Activated Protein Kinase, Modulates Abscisic Acid Responses through the MKK5-MPK6 Kinase Cascade. Plant Physiol. 2017;173:1391-1408 pubmed publisher
    ..Bimolecular fluorescence complementation analysis showed that MPK3, MPK6, and AIK1 interact with MKK5. The single mutant seedlings of mpk6 and mkk5 have similar phenotypes to aik1, but mkk4 does not...
  2. Ichimura K, Mizoguchi T, Irie K, Morris P, Giraudat J, Matsumoto K, et al. Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis. Biochem Biophys Res Commun. 1998;253:532-43 pubmed
    ..By contrast, other combinations of MAPKs and MAPKKs did not suppress these yeast mutations. These results suggest that ATMEKK1, ATMKK2/MEK1, and ATMPK4 may constitute a MAP kinase cascade. ..
  3. Patharkar O, Walker J. Floral organ abscission is regulated by a positive feedback loop. Proc Natl Acad Sci U S A. 2015;112:2906-11 pubmed publisher
    ..This study helps define the mechanisms and regulatory networks involved in a receptor-mediated signaling pathway that controls floral organ abscission. ..
  4. Zhao C, Nie H, Shen Q, Zhang S, Lukowitz W, Tang D. EDR1 physically interacts with MKK4/MKK5 and negatively regulates a MAP kinase cascade to modulate plant innate immunity. PLoS Genet. 2014;10:e1004389 pubmed publisher
    ..Here, we showed that EDR1 negatively regulates the MKK4/MKK5-MPK3/MPK6 kinase cascade in Arabidopsis...
  5. Liu H, Wang Y, Xu J, Su T, Liu G, Ren D. Ethylene signaling is required for the acceleration of cell death induced by the activation of AtMEK5 in Arabidopsis. Cell Res. 2008;18:422-32 pubmed publisher
    ..In a conditional gain-of-function transgenic system, the activation of AtMEK5, a MAPK kinase, can in turn activate endogenous AtMAPK3 and AtMAPK6, and can lead to a striking increase in ..
  6. Yamada K, Yamaguchi K, Shirakawa T, Nakagami H, Mine A, Ishikawa K, et al. The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation. EMBO J. 2016;35:2468-2483 pubmed
    ..These data indicate that PBL27 is the MAPKKK kinase that provides the missing link between the cell surface chitin receptor and the intracellular MAPK cascade in plants. ..
  7. Cho S, Larue C, Chevalier D, Wang H, Jinn T, Zhang S, et al. Regulation of floral organ abscission in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2008;105:15629-34 pubmed publisher
    ..protein kinases HAESA (HAE) and HAESA-like 2 (HSL2), the Mitogen-Activated Protein Kinase Kinase 4 (MKK4) and MKK5, and a dominant-negative form of Mitogen-Activated Protein Kinase 6 (MPK6) in a mpk3 mutant background all have ..
  8. Li K, Yang F, Miao Y, Song C. Abscisic acid signaling is involved in regulating the mitogen-activated protein kinase cascade module, AIK1-MKK5-MPK6. Plant Signal Behav. 2017;12:e1321188 pubmed publisher
    ..2 snrk2.3 and pyr1 pyl1 pyl2 pyl4 mutants. These results indicated that AIK1-MKK5-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth ..