Gene Symbol: MCCB
Description: 3-methylcrotonyl-CoA carboxylase
Alias: 3-METHYLCROTONYL-COA CARBOXYLASE, 3-methylcrotonyl-CoA carboxylase, F28A23.210, F28A23_210, 3-methylcrotonyl-CoA carboxylase
Species: thale cress

Top Publications

  1. Che P, Wurtele E, Nikolau B. Metabolic and environmental regulation of 3-methylcrotonyl-coenzyme A carboxylase expression in Arabidopsis. Plant Physiol. 2002;129:625-37 pubmed
    ..The observed expression patterns may indicate that one of the physiological roles of MCCase is to maintain the carbon status of the organism, possibly via the catabolism of leucine. ..
  2. Ding G, Che P, Ilarslan H, Wurtele E, Nikolau B. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. Plant J. 2012;70:562-77 pubmed publisher
    ..In Arabidopsis, two MCCase subunits (the biotinylated MCCA subunit and the non-biotinylated MCCB subunit) are each encoded by single genes (At1g03090 and At4g34030, respectively)...
  3. Taylor N, Heazlewood J, Day D, Millar A. Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis. Plant Physiol. 2004;134:838-48 pubmed
    ..The potential role of branched-chain amino acid catabolism as an oxidative phosphorylation energy source or as a detoxification pathway during plant stress is discussed. ..
  4. Obata K, Fukuda T, Morishita R, Abe S, Asakawa S, Yamaguchi S, et al. Human biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase gene (MCCA): cDNA sequence, genomic organization, localization to chromosomal band 3q27, and expression. Genomics. 2001;72:145-52 pubmed
    ..and entire coding regions in two patients with MCCase deficiency, but no sequence substitution was detected, suggesting that the gene mutations might be in the non-biotin-containing subunit (B subunit) gene, MCCB, in these patients.