Gene Symbol: LHY
Description: Homeodomain-like superfamily protein
Alias: LATE ELONGATED HYPOCOTYL, LATE ELONGATED HYPOCOTYL 1, LHY1, T25K16.6, T25K16_6, Homeodomain-like superfamily protein
Species: thale cress

Top Publications

  1. Pokhilko A, Fernández A, Edwards K, Southern M, Halliday K, Millar A. The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops. Mol Syst Biol. 2012;8:574 pubmed publisher
    ..Our computational analysis suggests that TOC1 is a repressor of the morning genes Late Elongated Hypocotyl and Circadian Clock Associated1 rather than an activator as first conceived...
  2. Li G, Siddiqui H, Teng Y, Lin R, Wan X, Li J, et al. Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis. Nat Cell Biol. 2011;13:616-22 pubmed publisher
    ..of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these ..
  3. Pruneda Paz J, Breton G, Para A, Kay S. A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock. Science. 2009;323:1481-5 pubmed publisher
    ..CHE is a clock component partially redundant with LHY in the repression of CCA1...
  4. Ding Z, Doyle M, Amasino R, Davis S. A complex genetic interaction between Arabidopsis thaliana TOC1 and CCA1/LHY in driving the circadian clock and in output regulation. Genetics. 2007;176:1501-10 pubmed
    It has been proposed that CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) together with TIMING OF CAB EXPRESSION 1 (TOC1) make up the central oscillator of the Arabidopsis thaliana circadian clock...
  5. Mizoguchi T, Wheatley K, Hanzawa Y, Wright L, Mizoguchi M, Song H, et al. LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis. Dev Cell. 2002;2:629-41 pubmed
    ..b>LHY and CCA1 are related MYB-like transcription factors proposed to be closely involved...
  6. Kikis E, Khanna R, Quail P. ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY. Plant J. 2005;44:300-13 pubmed
    ..that a negative transcriptional feedback loop formed by the genes CIRCADIAN CLOCK ASSOCIATED (CCA1), LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB (TOC1) constitutes the core of the central oscillator of the circadian clock in ..
  7. Fujiwara S, Oda A, Yoshida R, Niinuma K, Miyata K, Tomozoe Y, et al. Circadian clock proteins LHY and CCA1 regulate SVP protein accumulation to control flowering in Arabidopsis. Plant Cell. 2008;20:2960-71 pubmed publisher
    ..Here, we demonstrate that the circadian clock proteins LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) not only repressed the floral transition under short-day and ..
  8. Miyata K, Calviño M, Oda A, Sugiyama H, Mizoguchi T. Suppression of late-flowering and semi-dwarf phenotypes in the Arabidopsis clock mutant lhy-12;cca1-101 by phyB under continuous light. Plant Signal Behav. 2011;6:1162-71 pubmed publisher
    ..Double mutations in LHY and CCA1 (lhy;cca1) accelerated flowering under short days, mainly by the GI-CO dependent pathway...
  9. Ding Z, Millar A, Davis A, Davis S. TIME FOR COFFEE encodes a nuclear regulator in the Arabidopsis thaliana circadian clock. Plant Cell. 2007;19:1522-36 pubmed
    ..With regard to morning-acting genes, we unexpectedly found that TIC has a closer relationship with LATE ELONGATED HYPOCOTYL (LHY) than with CIRCADIAN CLOCK ASSOCIATED1, as tic has a specific LHY expression level defect...

More Information


  1. Spensley M, Kim J, Picot E, Reid J, Ott S, Helliwell C, et al. Evolutionarily conserved regulatory motifs in the promoter of the Arabidopsis clock gene LATE ELONGATED HYPOCOTYL. Plant Cell. 2009;21:2606-23 pubmed publisher
    The transcriptional regulation of the LATE ELONGATED HYPOCOTYL (LHY) gene is key to the structure of the circadian oscillator, integrating information from multiple regulatory pathways...
  2. Niwa Y, Ito S, Nakamichi N, Mizoguchi T, Niinuma K, Yamashino T, et al. Genetic linkages of the circadian clock-associated genes, TOC1, CCA1 and LHY, in the photoperiodic control of flowering time in Arabidopsis thaliana. Plant Cell Physiol. 2007;48:925-37 pubmed
    ..Nevertheless, the genetic linkages between the major clock-associated TOC1, CCA1 and LHY genes and the canonical CO-FT flowering pathway are less clear...
  3. Park B, Eo H, Jang I, Kang H, Song J, Seo H. Ubiquitination of LHY by SINAT5 regulates flowering time and is inhibited by DET1. Biochem Biophys Res Commun. 2010;398:242-6 pubmed publisher
    ..ligase SINAT5, an Arabidopsis homologue of the Drosophila SINA RING-finger protein, interacts directly with LHY, a component of the circadian oscillator, and DET1, a negative regulator of light-regulated gene expression...
  4. Song H, Carre I. DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock. Plant Mol Biol. 2005;57:761-71 pubmed
    ..interaction between DE-ETIOLATED 1 (DET1), a negative regulator of light-regulated gene expression, and LATE ELONGATED HYPOCOTYL (LHY), one of the core components of the circadian oscillator...
  5. Xie Q, Wang P, Liu X, Yuan L, Wang L, Zhang C, et al. LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator. Plant Cell. 2014;26:2843-57 pubmed publisher
    ..We conclude that LNK1 is a transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 through recruitment to their promoters via interaction with bona fide DNA binding proteins such as RVE4 and RVE8. ..
  6. Seo P, Park M, Lim M, Kim S, Lee M, Baldwin I, et al. A self-regulatory circuit of CIRCADIAN CLOCK-ASSOCIATED1 underlies the circadian clock regulation of temperature responses in Arabidopsis. Plant Cell. 2012;24:2427-42 pubmed publisher
    ..CCA1? interferes with the formation of CCA1?-CCA1? and LATE ELONGATED HYPOCOTYL (LHY)-LHY homodimers, as well as CCA1?-LHY heterodimers, by forming nonfunctional heterodimers with ..
  7. Song H, Noh Y. Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci. Mol Cells. 2012;34:279-87 pubmed
    Circadian clock genes are regulated by a transcriptional-translational feedback loop. In Arabidopsis, LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) transcripts are highly expressed in the morning...
  8. Nakamichi N, Kita M, Niinuma K, Ito S, Yamashino T, Mizoguchi T, et al. Arabidopsis clock-associated pseudo-response regulators PRR9, PRR7 and PRR5 coordinately and positively regulate flowering time through the canonical CONSTANS-dependent photoperiodic pathway. Plant Cell Physiol. 2007;48:822-32 pubmed
    ..Then, extensive genetic studies using CIRCADIAN CLOCK-ASSOCIATED1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) double mutants (cca1/lhy) and prr7/prr5 were conducted...
  9. Hemmes H, Henriques R, Jang I, Kim S, Chua N. Circadian clock regulates dynamic chromatin modifications associated with Arabidopsis CCA1/LHY and TOC1 transcriptional rhythms. Plant Cell Physiol. 2012;53:2016-29 pubmed publisher
    ..CIRCADIAN CLOCK ASSOCIATED 1 (CCA1)/LATE ELONGATED HYPOCOTYL (LHY) and TIMING OF CAB EXPRESSION 1 (TOC1) reciprocally repress genes encoding each other and are ..
  10. Lu S, Knowles S, Andronis C, Ong M, Tobin E. CIRCADIAN CLOCK ASSOCIATED1 and LATE ELONGATED HYPOCOTYL function synergistically in the circadian clock of Arabidopsis. Plant Physiol. 2009;150:834-43 pubmed publisher
    ..CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY) are Myb-related proteins that function in or close to the central oscillator in Arabidopsis (..
  11. Giraud E, Ng S, Carrie C, Duncan O, Low J, Lee C, et al. TCP transcription factors link the regulation of genes encoding mitochondrial proteins with the circadian clock in Arabidopsis thaliana. Plant Cell. 2010;22:3921-34 pubmed publisher
  12. Yoshida R, Fekih R, Fujiwara S, Oda A, Miyata K, Tomozoe Y, et al. Possible role of early flowering 3 (ELF3) in clock-dependent floral regulation by short vegetative phase (SVP) in Arabidopsis thaliana. New Phytol. 2009;182:838-50 pubmed publisher
    ..Double mutations in two clock genes, late elongated hypocotyl (LHY) and circadian clock associated 1 (CCA1), accelerated flowering under short days (SDs) but delayed ..
  13. Mizoguchi T, Wright L, Fujiwara S, Cremer F, Lee K, Onouchi H, et al. Distinct roles of GIGANTEA in promoting flowering and regulating circadian rhythms in Arabidopsis. Plant Cell. 2005;17:2255-70 pubmed
    ..We studied the relationship between the roles of GI in flowering and the circadian clock using late elongated hypocotyl circadian clock associated1 double mutants, which are impaired in circadian clock function, plants ..
  14. Dong M, Farré E, Thomashow M. Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:7241-6 pubmed publisher
    ..e., Circadian Clock-Associated 1 (CCA1) and Late Elongated Hypocotyl (LHY)...
  15. Schaffer R, Ramsay N, Samach A, Corden S, Putterill J, Carre I, et al. The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. Cell. 1998;93:1219-29 pubmed
    The dominant late elongated hypocotyl (lhy) mutation of Arabidopsis disrupted circadian clock regulation of gene expression and leaf movements and caused flowering to occur independently of photoperiod...
  16. Lau O, Huang X, Charron J, Lee J, Li G, Deng X. Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock. Mol Cell. 2011;43:703-12 pubmed publisher
    ..repression activity and physically interacts with two closely related MYB transcription factors, CCA1 and LHY, which are core components of the plant circadian clock...
  17. Ito S, Nakamichi N, Nakamura Y, Niwa Y, Kato T, Murakami M, et al. Genetic linkages between circadian clock-associated components and phytochrome-dependent red light signal transduction in Arabidopsis thaliana. Plant Cell Physiol. 2007;48:971-83 pubmed
    ..for Arabidopsis thaliana clock components are CCA1 (CIRCADIAN CLOCK-ASSOCIATED 1) and its homolog LHY (LATE ELONGATED HYPOCOTYL)...
  18. Sugano S, Andronis C, Ong M, Green R, Tobin E. The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis. Proc Natl Acad Sci U S A. 1999;96:12362-6 pubmed
    ..The circadian clock-associated 1 (CCA1) and the late elongated hypocotyl (LHY) proteins have been shown to be closely associated with clock function in Arabidopsis thaliana...
  19. Salome P, Weigel D, McClung C. The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and PRR9 in temperature compensation. Plant Cell. 2010;22:3650-61 pubmed publisher
    ..apparently due to hyperactivation of the transcription factors CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and LATE ELONGATED HYPOCOTYL (LHY)...
  20. Higham C, Husmeier D. A Bayesian approach for parameter estimation in the extended clock gene circuit of Arabidopsis thaliana. BMC Bioinformatics. 2013;14 Suppl 10:S3 pubmed publisher