Gene Symbol: LEUNIG
Description: transcriptional corepressor LEUNIG
Alias: L23H3.30, L23H3_30, LEUNIG, RON2, ROTUNDA 2, transcriptional corepressor LEUNIG
Species: thale cress

Top Publications

  1. Sitaraman J, Bui M, Liu Z. LEUNIG_HOMOLOG and LEUNIG perform partially redundant functions during Arabidopsis embryo and floral development. Plant Physiol. 2008;147:672-81 pubmed publisher
    ..In Arabidopsis (Arabidopsis thaliana), LEUNIG (LUG) and LEUNIG_HOMOLOG (LUH) encode two highly homologous proteins that are similar to the animal and fungal Gro/..
  2. Stahle M, Kuehlich J, Staron L, von Arnim A, Golz J. YABBYs and the transcriptional corepressors LEUNIG and LEUNIG_HOMOLOG maintain leaf polarity and meristem activity in Arabidopsis. Plant Cell. 2009;21:3105-18 pubmed publisher
    ..study, we show that YABs physically interact with components of a transcriptional repressor complex that include LEUNIG (LUG), LEUNIG_HOMOLOG (LUH), the LUG-associated coregulator SEUSS, and related SEUSS-LIKE proteins...
  3. Sridhar V, Surendrarao A, Gonzalez D, Conlan R, Liu Z. Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development. Proc Natl Acad Sci U S A. 2004;101:11494-9 pubmed
    ..b>LEUNIG (LUG) and SEUSS (SEU) normally act to prevent ectopic expression of the floral homeotic gene AGAMOUS in flowers...
  4. Walker M, Tehseen M, Doblin M, Pettolino F, Wilson S, Bacic A, et al. The transcriptional regulator LEUNIG_HOMOLOG regulates mucilage release from the Arabidopsis testa. Plant Physiol. 2011;156:46-60 pubmed publisher
    ..Suppression of the luh mutant phenotype was also observed when LEUNIG, a transcriptional corepressor closely related to LUH, was introduced in luh mutants under the control of the LUH ..
  5. Bui M, Lim N, Sijacic P, Liu Z. LEUNIG_HOMOLOG and LEUNIG regulate seed mucilage extrusion in Arabidopsis. J Integr Plant Biol. 2011;53:399-408 pubmed publisher
    b>LEUNIG (LUG) and LEUNIG_HOMOLOG (LUH) encode two closely related Arabidopsis proteins, belonging to the Gro/TLE family of transcriptional co-repressors...
  6. Huang J, Debowles D, Esfandiari E, Dean G, Carpita N, Haughn G. The Arabidopsis transcription factor LUH/MUM1 is required for extrusion of seed coat mucilage. Plant Physiol. 2011;156:491-502 pubmed publisher
    ..7, and ?-XYLOSIDASE1, was reduced relative to that of the wild type. Overexpression of MUM2 could partially rescue the mum1 phenotype. These data suggest that LUH/MUM1 is a positive regulator of all three genes. ..
  7. Grigorova B, Mara C, Hollender C, Sijacic P, Chen X, Liu Z. LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers. Development. 2011;138:2451-6 pubmed publisher
    ..We show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer whorls of A. thaliana flowers...
  8. Conner J, Liu Z. LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS expression during flower development. Proc Natl Acad Sci U S A. 2000;97:12902-7 pubmed
    Regulation of homeotic gene expression is critical for proper developmental patterns in both animals and plants. LEUNIG is a key regulator of the Arabidopsis floral homeotic gene AGAMOUS...
  9. Gonzalez D, Bowen A, Carroll T, Conlan R. The transcription corepressor LEUNIG interacts with the histone deacetylase HDA19 and mediator components MED14 (SWP) and CDK8 (HEN3) to repress transcription. Mol Cell Biol. 2007;27:5306-15 pubmed
    ..Using whole-genome arrays we show that the Arabidopsis thaliana corepressor LEUNIG, a member of the GroTLE transcription corepressor family, regulates the expression of multiple targets in vivo...

More Information


  1. Liu Z, Meyerowitz E. LEUNIG regulates AGAMOUS expression in Arabidopsis flowers. Development. 1995;121:975-91 pubmed
    b>LEUNIG was identified in a genetic screen designed to isolate second-site enhancer mutations of the floral homeotic mutant apetala2-1...
  2. Franks R, Liu Z, Fischer R. SEUSS and LEUNIG regulate cell proliferation, vascular development and organ polarity in Arabidopsis petals. Planta. 2006;224:801-11 pubmed
    ..We have investigated the role of the SEUSS and LEUNIG genes in Arabidopsis thaliana (L.) Heynh...
  3. Gregis V, Sessa A, Colombo L, Kater M. AGL24, SHORT VEGETATIVE PHASE, and APETALA1 redundantly control AGAMOUS during early stages of flower development in Arabidopsis. Plant Cell. 2006;18:1373-82 pubmed
    ..The observed phenotypes remarkably resembled the leunig (lug) and seuss (seu) mutants...
  4. Franks R, Wang C, Levin J, Liu Z. SEUSS, a member of a novel family of plant regulatory proteins, represses floral homeotic gene expression with LEUNIG. Development. 2002;129:253-63 pubmed
    ..The effects of seuss mutations are most striking when combined with mutations in LEUNIG, a previously identified repressor of AGAMOUS...
  5. Cnops G, Jover Gil S, Peters J, Neyt P, De Block S, Robles P, et al. The rotunda2 mutants identify a role for the LEUNIG gene in vegetative leaf morphogenesis. J Exp Bot. 2004;55:1529-39 pubmed
    ..The RON2 gene was positionally cloned and was identical to LEUNIG (LUG); it encodes a transcriptional co-repressor that has been described to affect flower development...
  6. Sridhar V, Surendrarao A, Liu Z. APETALA1 and SEPALLATA3 interact with SEUSS to mediate transcription repression during flower development. Development. 2006;133:3159-66 pubmed
    ..Previously, we identified and isolated two Arabidopsis transcription co-repressors LEUNIG (LUG) and SEUSS (SEU) that function together in a putative co-repressor complex to prevent ectopic AGAMOUS (AG) ..