Gene Symbol: LEC1
Description: Histone superfamily protein
Alias: AtLEC1, EMB 212, EMB212, EMBRYO DEFECTIVE 212, LEAFY COTYLEDON 1, NF-YB9, NUCLEAR FACTOR Y, SUBUNIT B9, T26F17.20, T26F17_20, Histone superfamily protein
Species: thale cress

Top Publications

  1. Kagaya Y, Toyoshima R, Okuda R, Usui H, Yamamoto A, Hattori T. LEAFY COTYLEDON1 controls seed storage protein genes through its regulation of FUSCA3 and ABSCISIC ACID INSENSITIVE3. Plant Cell Physiol. 2005;46:399-406 pubmed
    Arabidopsis ABSCISIC ACID INSENSEITIVE3 (ABI3), FUSCA3 (FUS3) and LEAFY COTYLEDON1 (LEC1) encode key transcription factors that control seed maturation events, including seed storage protein (SSP) accumulation...
  2. Calvenzani V, Testoni B, Gusmaroli G, Lorenzo M, Gnesutta N, Petroni K, et al. Interactions and CCAAT-binding of Arabidopsis thaliana NF-Y subunits. PLoS ONE. 2012;7:e42902 pubmed publisher
    ..we show that heterodimerization is possible among all histone-like subunits, including the divergent and related LEC1/AtNF-YB9 and L1L/AtNF-YB6 required for embryo development...
  3. Yamamoto A, Kagaya Y, Toyoshima R, Kagaya M, Takeda S, Hattori T. Arabidopsis NF-YB subunits LEC1 and LEC1-LIKE activate transcription by interacting with seed-specific ABRE-binding factors. Plant J. 2009;58:843-56 pubmed publisher
    b>LEAFY COTYLEDON 1 (LEC1) plays vital roles in the regulation of seed maturation in Arabidopsis. LEC1 encodes a homolog of yeast HAP3 or mammalian NF-YB/CBF-A subunit of trimeric CCAAT binding factor (CBF)...
  4. Suzuki M, Wang H, McCarty D. Repression of the LEAFY COTYLEDON 1/B3 regulatory network in plant embryo development by VP1/ABSCISIC ACID INSENSITIVE 3-LIKE B3 genes. Plant Physiol. 2007;143:902-11 pubmed
    Plant embryo development is regulated by a network of transcription factors that include LEAFY COTYLEDON 1 (LEC1), LEC1-LIKE (L1L), and B3 domain factors, LEAFY COTYLEDON 2 (LEC2), FUSCA3 (FUS3), and ABSCISIC ACID INSENSITIVE 3 (ABI3) of ..
  5. Mu J, Tan H, Zheng Q, Fu F, Liang Y, Zhang J, et al. LEAFY COTYLEDON1 is a key regulator of fatty acid biosynthesis in Arabidopsis. Plant Physiol. 2008;148:1042-54 pubmed publisher
    ..Here, we show that overexpression of the Arabidopsis (Arabidopsis thaliana) LEAFY COTYLEDON1 (LEC1) gene causes globally increased expression of fatty acid biosynthetic genes, which are involved in key reactions of ..
  6. Junker A, Mönke G, Rutten T, Keilwagen J, Seifert M, Thi T, et al. Elongation-related functions of LEAFY COTYLEDON1 during the development of Arabidopsis thaliana. Plant J. 2012;71:427-42 pubmed publisher
    The transcription factor LEAFY COTYLEDON1 (LEC1) controls aspects of early embryogenesis and seed maturation in Arabidopsis thaliana...
  7. Wenkel S, Turck F, Singer K, Gissot L, Le Gourrierec J, Samach A, et al. CONSTANS and the CCAAT box binding complex share a functionally important domain and interact to regulate flowering of Arabidopsis. Plant Cell. 2006;18:2971-84 pubmed
    ..During plant evolution, the number of genes encoding HAP proteins was greatly amplified, and these proteins may have acquired novel functions, such as mediating the effect of CCT domain proteins on gene expression. ..
  8. Gaj M, Zhang S, Harada J, Lemaux P. Leafy cotyledon genes are essential for induction of somatic embryogenesis of Arabidopsis. Planta. 2005;222:977-88 pubmed
    The capacity for somatic embryogenesis was studied in lec1, lec2 and fus3 mutants of Arabidopsis thaliana (L.) Heynh...
  9. Warpeha K, Upadhyay S, Yeh J, Adamiak J, Hawkins S, Lapik Y, et al. The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and abscisic acid responses in Arabidopsis. Plant Physiol. 2007;143:1590-600 pubmed
    ..Pirin1 (PRN1; one of four members of an iron-containing subgroup of the cupin superfamily), and a nuclear factor Y heterotrimer comprised of A5, B9, and possibly C9...

More Information


  1. Lotan T, Ohto M, Yee K, West M, Lo R, Kwong R, et al. Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryo development in vegetative cells. Cell. 1998;93:1195-205 pubmed
    The Arabidopsis LEAFY COTYLEDON1 (LEC1) gene is required for the specification of cotyledon identity and the completion of embryo maturation...
  2. Tao Z, Shen L, Gu X, Wang Y, Yu H, He Y. Embryonic epigenetic reprogramming by a pioneer transcription factor in plants. Nature. 2017;551:124-128 pubmed publisher
    ..Here we show that the seed-specific transcription factor LEAFY COTYLEDON1 (LEC1) promotes the initial establishment of an active chromatin state at FLC and activates its expression de novo in the ..
  3. Cao S, Kumimoto R, Gnesutta N, Calogero A, Mantovani R, Holt B. A distal CCAAT/NUCLEAR FACTOR Y complex promotes chromatin looping at the FLOWERING LOCUS T promoter and regulates the timing of flowering in Arabidopsis. Plant Cell. 2014;26:1009-17 pubmed publisher
    ..Additionally, we show that NUCLEAR FACTOR Y (NF-Y) binds a CCAAT box in the distal enhancer element and that CCAAT disruption dramatically reduces FT ..
  4. Huang M, Hu Y, Liu X, Li Y, Hou X. Arabidopsis LEAFY COTYLEDON1 Mediates Postembryonic Development via Interacting with PHYTOCHROME-INTERACTING FACTOR4. Plant Cell. 2015;27:3099-111 pubmed publisher
    ..Recent studies suggest LEAFY COTYLEDON1 (LEC1), initially identified as a central regulator in embryogenesis and seed maturation in Arabidopsis thaliana, plays a ..
  5. Jia H, Suzuki M, McCarty D. Regulation of the seed to seedling developmental phase transition by the LAFL and VAL transcription factor networks. Wiley Interdiscip Rev Dev Biol. 2014;3:135-45 pubmed publisher
    ..The AFL B3 factors together with LEC1-type HAP3 transcription factors promote embryo maturation; whereas the VAL B3 factors repress the LEC1/AFL (LAFL) ..
  6. Junker A, Bäumlein H. Multifunctionality of the LEC1 transcription factor during plant development. Plant Signal Behav. 2012;7:1718-20 pubmed publisher
    b>LEC1 acts as a key regulator of embryogenesis in Arabidopsis thaliana, but is involved in a wide range of functions, all the way from embryo morphogenesis to seed maturation...
  7. Kumimoto R, Siriwardana C, Gayler K, Risinger J, Siefers N, Holt B. NUCLEAR FACTOR Y transcription factors have both opposing and additive roles in ABA-mediated seed germination. PLoS ONE. 2013;8:e59481 pubmed publisher
    In the model organism Arabidopsis thaliana the heterotrimeric transcription factor NUCLEAR FACTOR Y (NF-Y) has been shown to play multiple roles in facilitating plant growth and development...
  8. Schneider A, Aghamirzaie D, Elmarakeby H, Poudel A, Koo A, Heath L, et al. Potential targets of VIVIPAROUS1/ABI3-LIKE1 (VAL1) repression in developing Arabidopsis thaliana embryos. Plant J. 2016;85:305-19 pubmed publisher
    ..Seed development and metabolism are positively regulated by transcription factors belonging to the LAFL (LEC1, AB13, FUSCA3 and LEC2) regulatory network...