Gene Symbol: LCB2
Description: long chain base2
Alias: MQM1.6, MQM1_6, SERINE PALMITOYLTRANSFERASE, long chain base2, long chain base2
Species: thale cress

Top Publications

  1. Chen M, Han G, Dietrich C, Dunn T, Cahoon E. The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase. Plant Cell. 2006;18:3576-93 pubmed publisher
    b>Serine palmitoyltransferase (SPT) catalyzes the first step of sphingolipid biosynthesis. In yeast and mammalian cells, SPT is a heterodimer that consists of LCB1 and LCB2 subunits, which together form the active site of this enzyme...
  2. Kimberlin A, Majumder S, Han G, Chen M, Cahoon R, Stone J, et al. Arabidopsis 56-amino acid serine palmitoyltransferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity. Plant Cell. 2013;25:4627-39 pubmed publisher
    Maintenance of sphingolipid homeostasis is critical for cell growth and programmed cell death (PCD). Serine palmitoyltransferase (SPT), composed of LCB1 and LCB2 subunits, catalyzes the primary regulatory point for sphingolipid synthesis...
  3. Dietrich C, Han G, Chen M, Berg R, Dunn T, Cahoon E. Loss-of-function mutations and inducible RNAi suppression of Arabidopsis LCB2 genes reveal the critical role of sphingolipids in gametophytic and sporophytic cell viability. Plant J. 2008;54:284-98 pubmed publisher
    b>Serine palmitoyltransferase (SPT) catalyzes the first step in sphingolipid biosynthesis, and downregulation of this enzyme provides a means for exploring sphingolipid function in cells...
  4. Saucedo García M, Guevara García A, González Solís A, Cruz García F, Vázquez Santana S, Markham J, et al. MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. New Phytol. 2011;191:943-57 pubmed publisher
    ..thaliana seedlings and analyzed LCB accumulation kinetics, cell ultrastructure and phenotypes in serine palmitoyltransferase (spt), mitogen-activated protein kinase (mpk), mitogen-activated protein phosphatase (mkp1) and lcb-..
  5. Tamura K, Mitsuhashi N, Hara Nishimura I, Imai H. Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Plant Cell Physiol. 2001;42:1274-81 pubmed
    b>Serine palmitoyltransferase (SPT; EC catalyzes the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine in the first step of de novo sphingolipid biosynthesis...
  6. Teng C, Dong H, Shi L, Deng Y, Mu J, Zhang J, et al. Serine palmitoyltransferase, a key enzyme for de novo synthesis of sphingolipids, is essential for male gametophyte development in Arabidopsis. Plant Physiol. 2008;146:1322-32 pubmed publisher
    ..De novo sphingolipid synthesis is initiated by a rate-limiting enzyme, serine palmitoyltransferase (SPT), a heterodimer consisting of LONG-CHAIN BASE1 (LCB1) and LCB2 subunits...
  7. Kimberlin A, Han G, Luttgeharm K, Chen M, Cahoon R, Stone J, et al. ORM Expression Alters Sphingolipid Homeostasis and Differentially Affects Ceramide Synthase Activity. Plant Physiol. 2016;172:889-900 pubmed
    ..b>Serine palmitoyltransferase (SPT) catalyzes the first step in sphingolipid biosynthesis and is considered the primary sphingolipid ..