LBA1

Summary

Gene Symbol: LBA1
Description: RNA helicase
Alias: ATUPF1, LOW-LEVEL BETA-AMYLASE 1, MQD22.15, MQD22_15, UPF1, RNA helicase
Species: thale cress

Top Publications

  1. Arciga Reyes L, Wootton L, Kieffer M, Davies B. UPF1 is required for nonsense-mediated mRNA decay (NMD) and RNAi in Arabidopsis. Plant J. 2006;47:480-9 pubmed
    ..Surprising differences have been reported in the mechanisms of NMD between different organisms. UPF1 and UPF3 are structurally unrelated proteins, which function in the NMD pathway in yeast, mammals, Drosophila and ..
  2. Mita S, Murano N, Akaike M, Nakamura K. Mutants of Arabidopsis thaliana with pleiotropic effects on the expression of the gene for beta-amylase and on the accumulation of anthocyanin that are inducible by sugars. Plant J. 1997;11:841-51 pubmed
    ..These results suggest that the sugar-regulated expression of many genes in plants might be mediated by multiple signal-transduction pathways. ..
  3. Yoine M, Nishii T, Nakamura K. Arabidopsis UPF1 RNA helicase for nonsense-mediated mRNA decay is involved in seed size control and is essential for growth. Plant Cell Physiol. 2006;47:572-80 pubmed
    UPF1 RNA helicase plays a central role in nonsense-mediated mRNA decay (NMD), which specifically recognizes aberrant mRNAs containing premature termination codons and targets them for degradation...
  4. Yoine M, Ohto M, Onai K, Mita S, Nakamura K. The lba1 mutation of UPF1 RNA helicase involved in nonsense-mediated mRNA decay causes pleiotropic phenotypic changes and altered sugar signalling in Arabidopsis. Plant J. 2006;47:49-62 pubmed
    ..lba1 was a missense mutation of UPF1 RNA helicase involved in nonsense-mediated mRNA decay (NMD), which eliminates mRNAs with premature termination codons (PTCs),..
  5. Schöning J, Streitner C, Page D, Hennig S, Uchida K, Wolf E, et al. Auto-regulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation. Plant J. 2007;52:1119-30 pubmed
    ..In mutants impaired in the nonsense-mediated decay (NMD) components UPF1 or UPF3, levels of the alternatively spliced AtGRP7 and AtGRP8 transcripts that contain premature termination ..
  6. Shi C, Baldwin I, Wu J. Arabidopsis plants having defects in nonsense-mediated mRNA decay factors UPF1, UPF2, and UPF3 show photoperiod-dependent phenotypes in development and stress responses. J Integr Plant Biol. 2012;54:99-114 pubmed publisher
    ..Three NMD factor proteins, UPF1, UPF2, and UPF3 are required for the NMD process and were found to be also involved in certain stress responses in ..
  7. Kurihara Y, Matsui A, Hanada K, Kawashima M, Ishida J, Morosawa T, et al. Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis. Proc Natl Acad Sci U S A. 2009;106:2453-8 pubmed publisher
    ..The UP-Frameshift (UPF) proteins, UPF1, UPF2, and UPF3, are essential for normal NMD function...
  8. Jeong H, Kim Y, Kim S, Kim Y, Lee I, Kim Y, et al. Nonsense-mediated mRNA decay factors, UPF1 and UPF3, contribute to plant defense. Plant Cell Physiol. 2011;52:2147-56 pubmed publisher
    In Arabidopsis, the NMD-defective mutants upf1-5 and upf3-1 are characterized by dwarfism, curly leaves and late flowering...
  9. Kim S, Koroleva O, Lewandowska D, Pendle A, Clark G, Simpson C, et al. Aberrant mRNA transcripts and the nonsense-mediated decay proteins UPF2 and UPF3 are enriched in the Arabidopsis nucleolus. Plant Cell. 2009;21:2045-57 pubmed publisher
    ..In addition, the NMD factors UPF3 and UPF2 localize to the nucleolus, suggesting that the Arabidopsis nucleolus is therefore involved in identifying aberrant mRNAs and NMD. ..

More Information

Publications11

  1. Mérai Z, Benkovics A, Nyikó T, Debreczeny M, Hiripi L, Kerényi Z, et al. The late steps of plant nonsense-mediated mRNA decay. Plant J. 2013;73:50-62 pubmed publisher
    ..If translation terminates at a PTC, the UPF1 NMD factor binds the terminating ribosome and recruits UPF2 and UPF3 to form a functional NMD complex, which ..
  2. Kerényi F, Wawer I, Sikorski P, Kufel J, Silhavy D. Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay. Plant J. 2013;76:836-48 pubmed publisher
    ..Targets for NMD are selected during translational termination. If termination is slow, the UPF1 NMD factor binds the eRF3 protein of the termination complex and then recruits UPF2 and UPF3...