KCO1

Summary

Gene Symbol: KCO1
Description: Outward rectifying potassium channel protein
Alias: ATKCO1, ATTPK1, CA2+ ACTIVATED OUTWARD RECTIFYING K+ CHANNEL 1, MDF20.7, MDF20_7, TANDEM PORE K+ CHANNEL 1, TPK1, TWO PORE K CHANNEL, TWO PORE K CHANNEL 1, Outward rectifying potassium channel protein
Species: thale cress

Top Publications

  1. Gobert A, Isayenkov S, Voelker C, Czempinski K, Maathuis F. The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis. Proc Natl Acad Sci U S A. 2007;104:10726-31 pubmed
    ..The most abundantly expressed isoform of this family, TPK1, is expressed at the tonoplast where it mediates K+ -selective currents between cytoplasmic and vacuolar ..
  2. Bihler H, Eing C, Hebeisen S, Roller A, Czempinski K, Bertl A. TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel. Plant Physiol. 2005;139:417-24 pubmed
    b>TPK1 (formerly KCO1) is the founding member of the family of two-pore domain K(+) channels in Arabidopsis (Arabidopsis thaliana), which originally was described following expression in Sf9 insect cells as a Ca(2+)- and voltage-dependent ..
  3. Voelker C, Schmidt D, Mueller Roeber B, Czempinski K. Members of the Arabidopsis AtTPK/KCO family form homomeric vacuolar channels in planta. Plant J. 2006;48:296-306 pubmed
    ..In contrast, AtTPK1 is a tonoplast-localized protein, that establishes a K+-selective, voltage-independent ion channel activated by ..
  4. Latz A, Becker D, Hekman M, Muller T, Beyhl D, Marten I, et al. TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins. Plant J. 2007;52:449-59 pubmed
    ..Here we show that AtTPK1 (KCO1), a vacuolar membrane localized K(+) channel of the TPK family, interacts with 14-3-3 proteins (general ..
  5. Schönknecht G, Spoormaker P, Steinmeyer R, Brüggeman L, Ache P, Dutta R, et al. KCO1 is a component of the slow-vacuolar (SV) ion channel. FEBS Lett. 2002;511:28-32 pubmed
    The Arabidopsis double pore K+ channel KCO1 was fused to green fluorescent protein and expressed in tobacco protoplasts. Microscopic analysis revealed a bright green fluorescence at the vacuolar membrane...
  6. Maîtrejean M, Wudick M, Voelker C, Prinsi B, Mueller Roeber B, Czempinski K, et al. Assembly and sorting of the tonoplast potassium channel AtTPK1 and its turnover by internalization into the vacuole. Plant Physiol. 2011;156:1783-96 pubmed publisher
    The assembly, sorting signals, and turnover of the tonoplast potassium channel AtTPK1 of Arabidopsis (Arabidopsis thaliana) were studied...
  7. Czempinski K, Frachisse J, Maurel C, Barbier Brygoo H, Mueller Roeber B. Vacuolar membrane localization of the Arabidopsis 'two-pore' K+ channel KCO1. Plant J. 2002;29:809-20 pubmed
    ..The K+ channel AtKCO1 from Arabidopsis thaliana is the prototype of a new family of plant K+ channels...
  8. Dunkel M, Latz A, Schumacher K, Muller T, Becker D, Hedrich R. Targeting of vacuolar membrane localized members of the TPK channel family. Mol Plant. 2008;1:938-49 pubmed publisher
    Four members of the tandem-pore potassium channel family of Arabidopsis thaliana (TPK1, 2, 3, and 5) reside in the vacuolar membrane, whereas TPK4 is a plasma membrane K(+)-channel...
  9. Czempinski K, Zimmermann S, Ehrhardt T, Müller Röber B. New structure and function in plant K+ channels: KCO1, an outward rectifier with a steep Ca2+ dependency. EMBO J. 1997;16:2565-75 pubmed
    ..We report the cloning and functional analysis of the first higher plant outward rectifying K+ channel (KCO1) from Arabidopsis thaliana...

More Information

Publications12

  1. Isayenkov S, Maathuis F. Arabidopsis thaliana vacuolar TPK channels form functional K? uptake pathways in Escherichia coli. Plant Signal Behav. 2013;8:e24665 pubmed publisher
    ..coli background.The expression of channels in bacteria was analyzed by RT-PCR. Our results show that AtTPK1, AtTPK2 and AtTPK5 are restoring the LB2003 growth on low K(+) media...
  2. van Kleeff P, Jaspert N, Li K, Rauch S, Oecking C, de Boer A. Higher order Arabidopsis 14-3-3 mutants show 14-3-3 involvement in primary root growth both under control and abiotic stress conditions. J Exp Bot. 2014;65:5877-88 pubmed publisher
  3. Latz A, Mehlmer N, Zapf S, Mueller T, Wurzinger B, Pfister B, et al. Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs). Mol Plant. 2013;6:1274-1289 pubmed publisher
    ..The Arabidopsis vacuolar two-pore K(+) channel 1 (TPK1) interacts with the 14-3-3 protein GRF6 (GF14-?)...