Gene Symbol: KAT3
Description: potassium channel protein
Alias: A. thaliana low-K+-tolerant 1, ARABIDOPSIS THALIANA K+ RECTIFYING CHANNEL 1, ATKC1, AtLKT1, F4D11.150, F4D11_150, K+ INWARD RECTIFYING CHANNEL PROTEIN, KC1, potassium channel in Arabidopsis thaliana 3, potassium channel protein
Species: thale cress
Products:     KAT3

Top Publications

  1. Duby G, Hosy E, Fizames C, Alcon C, Costa A, Sentenac H, et al. AtKC1, a conditionally targeted Shaker-type subunit, regulates the activity of plant K+ channels. Plant J. 2008;53:115-23 pubmed
    Amongst the nine voltage-gated K(+) channel (Kv) subunits expressed in Arabidopsis, AtKC1 does not seem to form functional Kv channels on its own, and is therefore said to be silent...
  2. Pilot G, Gaymard F, Mouline K, Chérel I, Sentenac H. Regulated expression of Arabidopsis shaker K+ channel genes involved in K+ uptake and distribution in the plant. Plant Mol Biol. 2003;51:773-87 pubmed
    ..Using the GUS reporter strategy, we have found that another Shaker channel gene, AtKC1, is expressed in epidermal and cortical cells in roots (supporting the hypothesis of a role in K+ uptake from the ..
  3. Honsbein A, Sokolovski S, Grefen C, Campanoni P, Pratelli R, Paneque M, et al. A tripartite SNARE-K+ channel complex mediates in channel-dependent K+ nutrition in Arabidopsis. Plant Cell. 2009;21:2859-77 pubmed publisher
    ..Here, we report that the Arabidopsis thaliana SNARE SYP121 binds to KC1, a regulatory K(+) channel subunit that assembles with different inward-rectifying K(+) channels to affect their ..
  4. Geiger D, Becker D, Vosloh D, Gambale F, Palme K, Rehers M, et al. Heteromeric AtKC1{middle dot}AKT1 channels in Arabidopsis roots facilitate growth under K+-limiting conditions. J Biol Chem. 2009;284:21288-95 pubmed publisher
    ..soil in Arabidopsis involves a root K(+) uptake module consisting of the two K(+) channel alpha-subunits, AKT1 and AtKC1. AKT1-mediated potassium absorption from K(+)-depleted soil was shown to depend on the calcium-sensing proteins ..
  5. Grefen C, Blatt M. Do calcineurin B-like proteins interact independently of the serine threonine kinase CIPK23 with the K+ channel AKT1? Lessons learned from a ménage à trois. Plant Physiol. 2012;159:915-9 pubmed publisher
  6. Grefen C, Chen Z, Honsbein A, Donald N, Hills A, Blatt M. A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis. Plant Cell. 2010;22:3076-92 pubmed publisher
    ..Recently, we reported that SYP121 also interacts directly with the K(+) channel subunit KC1 and forms a tripartite complex with a second K(+) channel subunit, AKT1, to control channel gating and K(+) ..
  7. Zhang A, Ren H, Tan Y, Qi G, Yao F, Wu G, et al. S-type Anion Channels SLAC1 and SLAH3 Function as Essential Negative Regulators of Inward K+ Channels and Stomatal Opening in Arabidopsis. Plant Cell. 2016;28:949-955 pubmed publisher
    ..Additionally, the inhibition of KAT1 by SLAC1 and KC1 only partially overlapped, suggesting that SLAC1 and KC1 inhibited K+in channels using different molecular ..
  8. Obrdlik P, El Bakkoury M, Hamacher T, Cappellaro C, Vilarino C, Fleischer C, et al. K+ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions. Proc Natl Acad Sci U S A. 2004;101:12242-7 pubmed
    ..of 84 plant proteins with K(+) channels as bait revealed differences in oligomerization between KAT1, AKT1, and AtKC1, and allowed detection of putative interacting partners of KAT1 and AtKC1...
  9. Wang Y, He L, Li H, Xu J, Wu W. Potassium channel alpha-subunit AtKC1 negatively regulates AKT1-mediated K(+) uptake in Arabidopsis roots under low-K(+) stress. Cell Res. 2010;20:826-37 pubmed publisher
    ..Here, we show that a Shaker-like potassium channel AtKC1, encoded by the AtLKT1 gene cloned from the Arabidopsis thaliana low-K(+) (LK)-tolerant mutant Atlkt1, significantly regulates AKT1-..

More Information


  1. Jeanguenin L, Alcon C, Duby G, Boeglin M, Chérel I, Gaillard I, et al. AtKC1 is a general modulator of Arabidopsis inward Shaker channel activity. Plant J. 2011;67:570-82 pubmed publisher
    ..In Arabidopsis thaliana, AtKC1, a Shaker ?-subunit that is silent when expressed alone, has been shown to regulate the activity of AKT1 by ..
  2. Zhang B, Karnik R, Wang Y, Wallmeroth N, Blatt M, Grefen C. The Arabidopsis R-SNARE VAMP721 Interacts with KAT1 and KC1 K+ Channels to Moderate K+ Current at the Plasma Membrane. Plant Cell. 2015;27:1697-717 pubmed publisher
    ..the plasma membrane, also interact with and suppress the activities of the inward-rectifying K(+) channels KAT1 and KC1. Interactions were evident in yeast split-ubiquitin assays, they were recovered in vivo by ratiometric bimolecular ..
  3. Wang X, Chen L, Liu W, Shen L, Wang F, Zhou Y, et al. AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis. Plant Physiol. 2016;170:2264-77 pubmed publisher
    ..conducts K(+) uptake in root cells, and its activity is regulated by CBL1/9-CIPK23 complexes as well as by the AtKC1 channel subunit...