Gene Symbol: KAT1
Description: 1
Alias: AtKAT1, MPL12.2, MPL12_2, potassium channel in Arabidopsis thaliana 1
Species: thale cress

Top Publications

  1. Sutter J, Sieben C, Hartel A, Eisenach C, Thiel G, Blatt M. Abscisic acid triggers the endocytosis of the arabidopsis KAT1 K+ channel and its recycling to the plasma membrane. Curr Biol. 2007;17:1396-402 pubmed
    ..controls ion transport and transpiration in plants under water stress, triggers the selective endocytosis of the KAT1 K+ channel protein in epidermal and guard cells...
  2. Riedelsberger J, Sharma T, Gonzalez W, Gajdanowicz P, Morales Navarro S, Garcia Mata C, et al. Distributed structures underlie gating differences between the kin channel KAT1 and the Kout channel SKOR. Mol Plant. 2010;3:236-45 pubmed publisher
    ..We have carried out a systematic program of domain swapping between the K(out) channel SKOR and the K(in) channel KAT1 to examine the impacts on gating of the pore regions, the S4, S5, and the S6 helices...
  3. Grabe M, Lai H, Jain M, Jan Y, Jan L. Structure prediction for the down state of a potassium channel voltage sensor. Nature. 2007;445:550-3 pubmed
    ..This screen relies on the ability of KAT1, a eukaryotic Kv channel, to conduct potassium when its VSDs are in the down state, thereby rescuing potassium-..
  4. Anderson J, Huprikar S, Kochian L, Lucas W, Gaber R. Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1992;89:3736-40 pubmed
    We report the isolation of a cDNA (KAT1) from Arabidopsis thaliana that encodes a probable K+ channel. KAT1 was cloned by its ability to suppress a K+ transport-defective phenotype in mutant Saccharomyces cerevisiae cells...
  5. Uozumi N, Nakamura T, Schroeder J, Muto S. Determination of transmembrane topology of an inward-rectifying potassium channel from Arabidopsis thaliana based on functional expression in Escherichia coli. Proc Natl Acad Sci U S A. 1998;95:9773-8 pubmed
    We report here that the inward-rectifying potassium channels KAT1 and AKT2 were functionally expressed in K+ uptake-deficient Escherichia coli. Immunological assays showed that KAT1 was translocated into the cell membrane of E. coli...
  6. Mikosch M, Hurst A, Hertel B, Homann U. Diacidic motif is required for efficient transport of the K+ channel KAT1 to the plasma membrane. Plant Physiol. 2006;142:923-30 pubmed
    ..In this study we analyzed the function of four diacidic DXE/DXD motifs of the plant K(+) channel KAT1. Mutation of the first diacidic DXE motif resulted in a strong reduction of the KAT1 conductance in both guard cell ..
  7. Ichida A, Pei Z, Baizabal Aguirre V, Turner K, Schroeder J. Expression of a Cs(+)-resistant guard cell K+ channel confers Cs(+)-resistant, light-induced stomatal opening in transgenic arabidopsis. Plant Cell. 1997;9:1843-57 pubmed
    ..Transgenic Arabidopsis plants were generated that expressed a mutant of the guard cell K+in channel, KAT1, which shows enhanced resistance to the Cs+ block...
  8. Choi H, Jeong S, Kim D, Na H, Ryu J, Lee S, et al. The homeodomain-leucine zipper ATHB23, a phytochrome B-interacting protein, is important for phytochrome B-mediated red light signaling. Physiol Plant. 2014;150:308-20 pubmed publisher
    ..Taken together, these results suggest that the ATHB23 transcription factor is a novel component of the phyB-mediated R light signaling pathway. ..
  9. Xicluna J, Lacombe B, Dreyer I, Alcon C, Jeanguenin L, Sentenac H, et al. Increased functional diversity of plant K+ channels by preferential heteromerization of the shaker-like subunits AKT2 and KAT2. J Biol Chem. 2007;282:486-94 pubmed
    ..In planta, these new channels, which may undergo specific regulations, are likely to be formed in guard cells and in the phloem, where they could participate in the control of membrane potential and potassium fluxes. ..

More Information


  1. Zhang B, Karnik R, Wang Y, Wallmeroth N, Blatt M, Grefen C. The Arabidopsis R-SNARE VAMP721 Interacts with KAT1 and KC1 K+ Channels to Moderate K+ Current at the Plasma Membrane. Plant Cell. 2015;27:1697-717 pubmed publisher
    ..to the plasma membrane, also interact with and suppress the activities of the inward-rectifying K(+) channels KAT1 and KC1...
  2. Obrdlik P, El Bakkoury M, Hamacher T, Cappellaro C, Vilarino C, Fleischer C, et al. K+ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions. Proc Natl Acad Sci U S A. 2004;101:12242-7 pubmed
    ..Homo- and heteromeric interactions between Arabidopsis K(+) channels KAT1, AKT1, and AKT2 were identified...
  3. Wang L, Yang S, Guo M, Huang Y, Sentenac H, Véry A, et al. The S1-S2 linker determines the distinct pH sensitivity between ZmK2.1 and KAT1. Plant J. 2016;85:675-85 pubmed publisher
    ..However, despite sequence and structural homologies, the maize counterpart of Arabidopsis KAT1 (ZmK2.1) is resistant to pH activation...
  4. Sato A, Sato Y, Fukao Y, Fujiwara M, Umezawa T, Shinozaki K, et al. Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase. Biochem J. 2009;424:439-48 pubmed publisher
    The Arabidopsis thaliana K+ channel KAT1 has been suggested to have a key role in mediating the aperture of stomata pores on the surface of plant leaves...
  5. Hibi T, Aoki S, Oda K, Munemasa S, Ozaki S, Shirai O, et al. Purification of the functional plant membrane channel KAT1. Biochem Biophys Res Commun. 2008;374:465-9 pubmed publisher
    The inward-rectifying K(+) channel KAT1 is expressed mainly in Arabidopsis thaliana guard cells. The purification of functional KAT1 has never been reported...
  6. Zhang A, Ren H, Tan Y, Qi G, Yao F, Wu G, et al. S-type Anion Channels SLAC1 and SLAH3 Function as Essential Negative Regulators of Inward K+ Channels and Stomatal Opening in Arabidopsis. Plant Cell. 2016;28:949-955 pubmed publisher
    ..Here we show that S-type anion channels SLAC1 and SLAH3 mainly inhibit inward K+ (K+in) channel KAT1 by protein-protein interaction, and consequently prevent stomatal opening in Arabidopsis...
  7. Sato A, Gambale F, Dreyer I, Uozumi N. Modulation of the Arabidopsis KAT1 channel by an activator of protein kinase C in Xenopus laevis oocytes. FEBS J. 2010;277:2318-28 pubmed publisher
    The Arabidopsis thaliana K(+) channel KAT1 has been suggested to play a key role in the regulation of the aperture of stomatal pores on the surface of plant leaves...
  8. Hertel B, Horvath F, Wodala B, Hurst A, Moroni A, Thiel G. KAT1 inactivates at sub-millimolar concentrations of external potassium. J Exp Bot. 2005;56:3103-10 pubmed
    ..In the present study, the effect of depleting Ko+ on the activity of a plant K+ channel, KAT1, from Arabidopsis thaliana was investigated. This channel is thought to be insensitive to Ko+...
  9. Liu K, Li L, Luan S. An essential function of phosphatidylinositol phosphates in activation of plant shaker-type K+ channels. Plant J. 2005;42:433-43 pubmed
    ..We also identified aluminum block as a common feature of the plant shaker-type channels and provided evidence that aluminum block of these channels may result from Al interaction with PIPs. ..
  10. Reuff M, Mikosch M, Homann U. Trafficking, lateral mobility and segregation of the plant K channel KAT1. Plant Biol (Stuttg). 2010;12 Suppl 1:99-104 pubmed publisher
    ..Here, we summarize studies on trafficking and plasma membrane distribution of the plant K(+) channel KAT1 from Arabidopsis thaliana...
  11. Ronzier E, Corratgé Faillie C, Sanchez F, Prado K, Briere C, Leonhardt N, et al. CPK13, a noncanonical Ca2+-dependent protein kinase, specifically inhibits KAT2 and KAT1 shaker K+ channels and reduces stomatal opening. Plant Physiol. 2014;166:314-26 pubmed publisher
    ..evidence that CPK13 (1) specifically phosphorylates peptide arrays featuring Arabidopsis K(+) Channel KAT2 and KAT1 polypeptides, (2) inhibits KAT2 and/or KAT1 when expressed in Xenopus laevis oocytes, and (3) closely interacts in ..
  12. Islam M, Ye W, Matsushima D, Khokon M, Munemasa S, Nakamura Y, et al. Inhibition by acrolein of light-induced stomatal opening through inhibition of inward-rectifying potassium channels in Arabidopsis thaliana. Biosci Biotechnol Biochem. 2015;79:59-62 pubmed publisher
    ..Acrolein at 100 μM inhibited Kin channel KAT1 expressed in a heterologous system using Xenopus leaves oocytes...
  13. Tang H, Vasconcelos A, Berkowitz G. Physical association of KAB1 with plant K+ channel alpha subunits. Plant Cell. 1996;8:1545-53 pubmed
    ..that the KAB1 polypeptide forms a tight physical association with the Arabidopsis K+ channel alpha subunit, KAT1. An affinity-purified KAB1 fusion protein was immobilized to a support resin and shown to sequester selectively the ..
  14. Chérel I, Michard E, Platet N, Mouline K, Alcon C, Sentenac H, et al. Physical and functional interaction of the Arabidopsis K(+) channel AKT2 and phosphatase AtPP2CA. Plant Cell. 2002;14:1133-46 pubmed
    ..Regulation of AKT2 activity by AtPP2CA in planta could allow the control of K(+) transport and membrane polarization during stress situations. ..
  15. Pilot G, Lacombe B, Gaymard F, Cherel I, Boucherez J, Thibaud J, et al. Guard cell inward K+ channel activity in arabidopsis involves expression of the twin channel subunits KAT1 and KAT2. J Biol Chem. 2001;276:3215-21 pubmed
    ..b>KAT1 was the only inward K(+) channel shown to be expressed in Arabidopsis guard cells, where it was proposed to mediate ..
  16. Gonzalez W, Riedelsberger J, Morales Navarro S, Caballero J, Alzate Morales J, Gonzalez Nilo F, et al. The pH sensor of the plant K+-uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids. Biochem J. 2012;442:57-63 pubmed publisher
    ..However, in the Arabidopsis thaliana stomatal K(in) channel KAT1, mutations in the unique histidine exposed to the solvent (His267) do not affect the pH dependency...
  17. Lefoulon C, Karnik R, Honsbein A, Gutla P, Grefen C, Riedelsberger J, et al. Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor. Plant Physiol. 2014;166:960-75 pubmed publisher
    The Kv-like (potassium voltage-dependent) K(+) channels at the plasma membrane, including the inward-rectifying KAT1 K(+) channel of Arabidopsis (Arabidopsis thaliana), are important targets for manipulating K(+) homeostasis in plants...
  18. Schachtman D, Schroeder J, Lucas W, Anderson J, Gaber R. Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA. Science. 1992;258:1654-8 pubmed
    ..This report shows that a single messenger RNA transcript from the Arabidopsis thaliana KAT1 complementary DNA confers the functional expression of a hyperpolarization-activated K+ channel in Xenopus oocytes...
  19. Sutter J, Campanoni P, Tyrrell M, Blatt M. Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane. Plant Cell. 2006;18:935-54 pubmed
    ..protein and externally exposed hemagglutinin epitopes to monitor the distribution and trafficking dynamics of the KAT1 K(+) channel transiently expressed in tobacco leaves...