Gene Symbol: IRX1
Description: cellulose synthase family protein
Alias: ATCESA8, CELLULOSE SYNTHASE 8, CESA8, F28A21.190, F28A21_190, IRREGULAR XYLEM 1, LEAF WILTING 2, LEW2, cellulose synthase family protein
Species: thale cress
Products:     IRX1

Top Publications

  1. Timmers J, Vernhettes S, Desprez T, Vincken J, Visser R, Trindade L. Interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall. FEBS Lett. 2009;583:978-82 pubmed publisher
    ..A model is proposed for the secondary rosette structure. The RING-motif proved not to be essential for the interaction between the CESA proteins. ..
  2. Taylor N, Howells R, Huttly A, Vickers K, Turner S. Interactions among three distinct CesA proteins essential for cellulose synthesis. Proc Natl Acad Sci U S A. 2003;100:1450-5 pubmed
    ..irx5 plants have an identical phenotype to previously described mutations in two other members of this gene family (IRX1 and IRX3)...
  3. Zhong R, Demura T, Ye Z. SND1, a NAC domain transcription factor, is a key regulator of secondary wall synthesis in fibers of Arabidopsis. Plant Cell. 2006;18:3158-70 pubmed
    ..Together, our results reveal that SND1 is a key transcriptional activator involved in secondary wall biosynthesis in fibers. ..
  4. Brown D, Zeef L, Ellis J, Goodacre R, Turner S. Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics. Plant Cell. 2005;17:2281-95 pubmed
    ..exhibit a similar expression pattern to the secondary cell wall-specific cellulose synthase genes IRREGULAR XYLEM1 (IRX1) and IRX3...
  5. Zhang Y, Nikolovski N, Sorieul M, Vellosillo T, McFarlane H, Dupree R, et al. Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis. Nat Commun. 2016;7:11656 pubmed publisher
    ..Point mutations in the predicted catalytic domains of the STELLO proteins indicate that they are glycosyltransferases facing the Golgi lumen. Hence, we have uncovered proteins that regulate CSC assembly in the plant Golgi apparatus. ..
  6. Turner S, Somerville C. Collapsed xylem phenotype of Arabidopsis identifies mutants deficient in cellulose deposition in the secondary cell wall. Plant Cell. 1997;9:689-701 pubmed
    ..The mutations should be useful in facilitating the identification of factors that control the synthesis and deposition of cellulose and other cell wall components. ..
  7. Mansoori N, Timmers J, Desprez T, Alvim Kamei C, Kamei C, Dees D, et al. KORRIGAN1 interacts specifically with integral components of the cellulose synthase machinery. PLoS ONE. 2014;9:e112387 pubmed publisher
    ..The KOR1 transmembrane domain has shown to be required for the interaction between KOR1 and the different CESAs, as well as for higher oligomer formation of KOR1. ..
  8. Taylor N, Laurie S, Turner S. Multiple cellulose synthase catalytic subunits are required for cellulose synthesis in Arabidopsis. Plant Cell. 2000;12:2529-2540 pubmed
    The irregular xylem 1 (irx1) mutant of Arabidopsis has a severe deficiency in the deposition of cellulose in secondary cell walls, which results in collapsed xylem cells. This mutation has been mapped to a 140-kb region of chromosome 4...
  9. Chen Z, Hong X, Zhang H, Wang Y, Li X, Zhu J, et al. Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J. 2005;43:273-83 pubmed
    Two allelic Arabidopsis mutants, leaf wilting 2-1 and leaf wilting 2-2 (lew2-1 and lew2-2 ), were isolated in a screen for plants with altered drought stress responses...

More Information


  1. Atanassov I, Pittman J, Turner S. Elucidating the mechanisms of assembly and subunit interaction of the cellulose synthase complex of Arabidopsis secondary cell walls. J Biol Chem. 2009;284:3833-41 pubmed publisher
    ..These preparations consisted solely of the three known secondary cell wall CESA proteins CESA4, CESA7, and CESA8. No additional CESA isoforms or other proteins were identified...
  2. Hernández Blanco C, Feng D, Hu J, Sanchez Vallet A, Deslandes L, Llorente F, et al. Impairment of cellulose synthases required for Arabidopsis secondary cell wall formation enhances disease resistance. Plant Cell. 2007;19:890-903 pubmed
    ..In Arabidopsis thaliana, three types of CESA subunits (CESA4/IRREGULAR XYLEM5 [IRX5], CESA7/IRX3, and CESA8/IRX1) are required for secondary cell wall formation...
  3. Betancur L, Singh B, Rapp R, Wendel J, Marks M, Roberts A, et al. Phylogenetically distinct cellulose synthase genes support secondary wall thickening in arabidopsis shoot trichomes and cotton fiber. J Integr Plant Biol. 2010;52:205-20 pubmed publisher
  4. Carroll A, Mansoori N, Li S, Lei L, Vernhettes S, Visser R, et al. Complexes with mixed primary and secondary cellulose synthases are functional in Arabidopsis plants. Plant Physiol. 2012;160:726-37 pubmed publisher
    ..used to assess the interactions between three primary (CESA1, CESA3, CESA6), and three secondary (CESA4, CESA7, CESA8) Arabidopsis (Arabidopsis thaliana) CESAs...