Gene Symbol: IAA12
Description: AUX/IAA transcriptional regulator family protein
Alias: BDL, BODENLOS, T1G11.20, T1G11_20, indole-3-acetic acid inducible 12, AUX/IAA transcriptional regulator family protein
Species: thale cress
Products:     IAA12

Top Publications

  1. Dharmasiri N, Dharmasiri S, Weijers D, Lechner E, Yamada M, Hobbie L, et al. Plant development is regulated by a family of auxin receptor F box proteins. Dev Cell. 2005;9:109-19 pubmed
    ..in all four proteins are auxin insensitive and exhibit a severe embryonic phenotype similar to the mp/arf5 and bdl/iaa12 mutants. Correspondingly, all TIR1/AFB proteins interact with BDL, and BDL is stabilized in triple mutant plants...
  2. Szemenyei H, Hannon M, Long J. TOPLESS mediates auxin-dependent transcriptional repression during Arabidopsis embryogenesis. Science. 2008;319:1384-6 pubmed publisher
    ..We show that TOPLESS (TPL) can physically interact with IAA12/BODENLOS (IAA12/BDL) through an ETHYLENE RESPONSE FACTOR (ERF)-associated amphiphilic repression (EAR) motif...
  3. Hamann T, Mayer U, Jurgens G. The auxin-insensitive bodenlos mutation affects primary root formation and apical-basal patterning in the Arabidopsis embryo. Development. 1999;126:1387-95 pubmed
    ..We have isolated a mutant of a new gene named BODENLOS (BDL) in which the primary root meristem is not formed whereas post-embryonic roots develop and bdl seedlings ..
  4. Hamann T, Benkova E, Bäurle I, Kientz M, Jurgens G. The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes Dev. 2002;16:1610-5 pubmed
    ..monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate the root meristem during early embryogenesis...
  5. Maraschin F, Memelink J, Offringa R. Auxin-induced, SCF(TIR1)-mediated poly-ubiquitination marks AUX/IAA proteins for degradation. Plant J. 2009;59:100-9 pubmed publisher
    ..protoplast system to find evidence for SCF(TIR1)-mediated ubiquitination of the Aux/IAA proteins SHY2/IAA3 and BDL/IAA12. Each of these proteins showed a distinct abundance and repressor activity when expressed in this cell system...
  6. Calderon Villalobos L, Lee S, de Oliveira C, Ivetac A, Brandt W, Armitage L, et al. A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin. Nat Chem Biol. 2012;8:477-85 pubmed publisher
    ..This co-receptor system broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response. ..
  7. Garrett J, Meents M, Blackshaw M, Blackshaw L, Hou H, Styranko D, et al. A novel, semi-dominant allele of MONOPTEROS provides insight into leaf initiation and vein pattern formation. Planta. 2012;236:297-312 pubmed publisher
    ..predicted to encode a truncated product that lacks domain IV required for interaction with its Aux/IAA repressor BODENLOS (BDL). We show that the truncated product fails to interact with BDL in yeast two-hybrid assays...
  8. Pahari S, Cormark R, Blackshaw M, Liu C, Erickson J, Schultz E. Arabidopsis UNHINGED encodes a VPS51 homolog and reveals a role for the GARP complex in leaf shape and vein patterning. Development. 2014;141:1894-905 pubmed publisher
    ..Our results suggest that UNH is important for reducing expression of PIN1 within margin cells, possibly by targeting PIN1 to the lytic vacuole. ..
  9. Yu H, Zhang Y, Moss B, Bargmann B, Wang R, Prigge M, et al. Untethering the TIR1 auxin receptor from the SCF complex increases its stability and inhibits auxin response. Nat Plants. 2015;1: pubmed
    ..Finally, we show that a key amino acid variation in the F-box domain of auxin signalling F-box (AFB1), a closely related FBP, reduces its ability to form an SCF, resulting in an increase in AFB1 levels. ..

More Information


  1. Hardtke C, Ckurshumova W, Vidaurre D, Singh S, Stamatiou G, Tiwari S, et al. Overlapping and non-redundant functions of the Arabidopsis auxin response factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4. Development. 2004;131:1089-100 pubmed
    ..Overexpression of MP suppresses numerous defects associated with a gain-of-function mutation in BODENLOS (BDL)/IAA12...
  2. Li J, Bush J, Xiong Y, Li L, McCormack M. Large-scale protein-protein interaction analysis in Arabidopsis mesophyll protoplasts by split firefly luciferase complementation. PLoS ONE. 2011;6:e27364 pubmed publisher
    ..Our results demonstrated that the SFLC assay is ideal for in vivo quantitative PPI analysis in plant cells and is particularly powerful for large-scale binary PPI screens...
  3. Nanao M, Vinos Poyo T, Brunoud G, Thevenon E, Mazzoleni M, Mast D, et al. Structural basis for oligomerization of auxin transcriptional regulators. Nat Commun. 2014;5:3617 pubmed publisher
    ..We further provide evidence that ARFs have the potential to oligomerize, a property that could be important for gene regulation in response to auxin. ..
  4. De Smet I, Lau S, Ehrismann J, Axiotis I, Kolb M, Kientz M, et al. Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana. J Exp Bot. 2013;64:3009-19 pubmed publisher
    ..For example, apart from auxin-linked regulatory inputs, factors regulating the expression of the AUX/IAA BODENLOS (BDL)/IAA12 are not known...