Gene Symbol: HYH
Description: HY5-homolog
Alias: HY5-homolog, HY5-homolog
Species: thale cress

Top Publications

  1. Holm M, Ma L, Qu L, Deng X. Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Genes Dev. 2002;16:1247-59 pubmed
    ..Here we identify a novel bZIP protein HYH, as a new target of COP1...
  2. Subramanian C, Woo J, Cai X, Xu X, Servick S, Johnson C, et al. A suite of tools and application notes for in vivo protein interaction assays using bioluminescence resonance energy transfer (BRET). Plant J. 2006;48:138-52 pubmed
    ..COP1 and the B-box protein STH, and interaction between the light regulatory bZip transcription factors HY5 and HYH. A codon-optimized version of the Renilla luciferase gene resulted in improved expression in Arabidopsis...
  3. Singh A, Ram H, Abbas N, Chattopadhyay S. Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana. J Biol Chem. 2012;287:25995-6009 pubmed publisher
    ..Whereas the bZIP proteins, HY5 (elongated hypocotyl 5) and HYH (HY5 homologue), are degraded by COP1-mediated proteasomal pathways, GBF1 is degraded by a proteasomal pathway ..
  4. Desai M, Hu J. Light induces peroxisome proliferation in Arabidopsis seedlings through the photoreceptor phytochrome A, the transcription factor HY5 HOMOLOG, and the peroxisomal protein PEROXIN11b. Plant Physiol. 2008;146:1117-27 pubmed publisher
    ..The far-red light receptor phytochrome A (phyA) and the bZIP transcription factor HY5 HOMOLOG (HYH) are both required for the up-regulation of PEX11b in the light...
  5. Ram H, Priya P, Jain M, Chattopadhyay S. Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH. Mol Plant. 2014;7:448-51 pubmed publisher
  6. Zhang Y, Zheng S, Liu Z, Wang L, Bi Y. Both HY5 and HYH are necessary regulators for low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. J Plant Physiol. 2011;168:367-74 pubmed publisher
    The roles of two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) in inducing anthocyanin accumulation during low temperature treatment were studied in Arabidopsis...
  7. Sibout R, Sukumar P, Hettiarachchi C, Holm M, Muday G, Hardtke C. Opposite root growth phenotypes of hy5 versus hy5 hyh mutants correlate with increased constitutive auxin signaling. PLoS Genet. 2006;2:e202 pubmed
    ..Mutants in the close HY5 homolog HYH resemble wild-type, despite the largely similar expression patterns and levels of HY5 and HYH, and the ..
  8. Maurya J, Sethi V, Gangappa S, Gupta N, Chattopadhyay S. Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development. Plant J. 2015;83:439-50 pubmed publisher
    ..This study further reveals that MYC2 and GBF1 bind to HYH promoter and inhibit each other through non-DNA binding bHLH-bZIP heterodimers...
  9. Zhang Y, Liu Z, Liu R, Hao H, Bi Y. Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner. Plant Signal Behav. 2011;6:632-4 pubmed
    ..Recently, two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HOMOLOG OF HY5 (HYH) were identified to play an important role in the process of low temperature-induced anthocyanin accumulation...

More Information


  1. Shi Q, Yang X, Song L, Xue H. Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation. Mol Plant. 2011;4:1092-104 pubmed publisher
    ..shift assay (EMSA), and a Chromatin IP (ChIP) assay confirmed the direct binding of Long Hypocotyl 5 (HY5) and HY5 Homolog (HYH) to the promoter region of MSBP1, indicating that MSBP1 is involved in light-regulated hypocotyl growth by ..
  2. Jonassen E, Lea U, Lillo C. HY5 and HYH are positive regulators of nitrate reductase in seedlings and rosette stage plants. Planta. 2008;227:559-64 pubmed
    HY5 and HYH are bZIP transcription factors well known to be involved in photomorphogenesis and light signalling...
  3. He Z, Zhao X, Kong F, Zuo Z, Liu X. TCP2 positively regulates HY5/HYH and photomorphogenesis in Arabidopsis. J Exp Bot. 2016;67:775-85 pubmed publisher
    ..light affected TCP2 expression in a wavelength-dependent manner and TCP2 positively regulates mRNA expression of HYH and HY5...
  4. Gangappa S, Holm M, Botto J. Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development. Plant Signal Behav. 2013;8: pubmed publisher
    ..1) Furthermore, HY5 HOMOLOG, HYH, has been reported to heterodimerize with HY5 and enhances its photomorphogenic function in seedling de-..
  5. Jonassen E, Sévin D, Lillo C. The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1. J Plant Physiol. 2009;166:2071-6 pubmed publisher
    ..in Arabidopsis seedlings and rosette stage leaves when the basic leucine zipper transcription factors HY5 and HYH were absent...
  6. Chen D, Xu G, Tang W, Jing Y, Ji Q, Fei Z, et al. Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis. Plant Cell. 2013;25:1657-73 pubmed publisher
    ..transcription factors PHYTOCHROME-INTERACTING FACTOR1 (PIF1), PIF3, ELONGATED HYPOCOTYL5 (HY5), and HY5 HOMOLOGY (HYH) that bridge light and ROS signaling to regulate cell death and photooxidative response...
  7. Safrany J, Haasz V, Mate Z, Ciolfi A, Feher B, Oravecz A, et al. Identification of a novel cis-regulatory element for UV-B-induced transcription in Arabidopsis. Plant J. 2008;54:402-14 pubmed publisher
  8. Zhang Y, Li C, Zhang J, Wang J, Yang J, Lv Y, et al. Dissection of HY5/HYH expression in Arabidopsis reveals a root-autonomous HY5-mediated photomorphogenic pathway. PLoS ONE. 2017;12:e0180449 pubmed publisher
    ..Whereas the hy5 mutant exhibits an elongated hypocotyl when grown in the light, the hy5 homolog (hyh) mutant does not...
  9. Brown B, Jenkins G. UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH. Plant Physiol. 2008;146:576-88 pubmed
    ..Genes encoding the ELONGATED HYPOCOTYL5 (HY5) and HY5 HOMOLOG (HYH) transcription factors are induced at low UV-B fluence rates (0.1 micromol m(-2) s(-1))...