HY5

Summary

Gene Symbol: HY5
Description: transcription factor HY5
Alias: BZIP TRANSCRIPTION FACTOR HY5, ELONGATED HYPOCOTYL 5, F2I11.150, F2I11_150, REVERSAL OF THE DET PHENOTYPE 5, TED 5
Species: thale cress

Top Publications

  1. pmc Integration of light and abscisic acid signaling during seed germination and early seedling development
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Proc Natl Acad Sci U S A 105:4495-500. 2008
  2. pmc HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression
    Bridey B Maxwell
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Plant Physiol 133:1565-77. 2003
  3. ncbi Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development
    L H Ang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell 1:213-22. 1998
  4. pmc Opposite root growth phenotypes of hy5 versus hy5 hyh mutants correlate with increased constitutive auxin signaling
    Richard Sibout
    Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 2:e202. 2006
  5. pmc Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development
    Ritu Kushwaha
    National Institute for Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    Plant Cell 20:1747-59. 2008
  6. doi The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1
    Else M Jonassen
    University of Stavanger, Centre for Organelle Research, Faculty of Science and Technology, N 4036 Stavanger, Norway
    J Plant Physiol 166:2071-6. 2009
  7. pmc Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1
    M Holm
    Department of Molecular, Cellular and Developmental Biology, Yale University, OML 354, Yale University, PO Box 20 8104, 165 Prospect Street, New Haven, CT 06520 8104, USA
    EMBO J 20:118-27. 2001
  8. pmc Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis
    Magnus Holm
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Genes Dev 16:1247-59. 2002
  9. pmc HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain
    C S Hardtke
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    EMBO J 19:4997-5006. 2000
  10. pmc Arabidopsis bZIP protein HY5 directly interacts with light-responsive promoters in mediating light control of gene expression
    S Chattopadhyay
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Plant Cell 10:673-83. 1998

Scientific Experts

  • Yongqiang Zhang
  • Tatsuya Sawasaki
  • Roman Ulm
  • J L Riechmann
  • Xing Wang Deng
  • Gang Li
  • Jigang Li
  • Magnus Holm
  • Huiyong Zhang
  • Hao Chen
  • Giltsu Choi
  • Bobby A Brown
  • Vicente Rubio
  • Yanjun Jing
  • Dongqin Chen
  • Jieun Shin
  • Rongcheng Lin
  • Xi Huang
  • Aparna Singh
  • Sudip Chattopadhyay
  • Sourav Datta
  • Chamari Hettiarachchi
  • Ute Hoecker
  • X W Deng
  • Yunping Shen
  • Haiyang Wang
  • Mintu Desai
  • Rajnish Khanna
  • Attila Oravecz
  • Dong Ho Shin
  • Weijiang Tang
  • Sreeramaiah N Gangappa
  • Gang Xu
  • Alexander Maier
  • Mark T Waters
  • Lei Jiang
  • Young Hun Song
  • Fang Chen
  • Peter Kindgren
  • Babu Rajendra V Prasad
  • Cornelia Klose
  • Xinhao Ouyang
  • Mingqiu Dai
  • On Sun Lau
  • Qiu Ming Shi
  • Bok Rye Lee
  • Zhenzhen Zhou
  • Romina Sellaro
  • Zhuofu Li
  • Xiao Dong Sun
  • Hans E Holtan
  • Henrik Johansson
  • Ralf Stracke
  • Tobias Kirchler
  • Christian S Hardtke
  • Markus Nixdorf
  • Liming Xiong
  • Ilha Lee
  • Eberhard Schafer
  • Cristina Martinez
  • Else M Jonassen
  • Yu Shen
  • Gareth I Jenkins
  • Cathrine Lillo
  • Chiung swey Joanne Chang
  • Ritu Kushwaha
  • Else Müller Jonassen
  • Judit Safrany
  • David Alabadi
  • Michael E Ruckle
  • Jungeun Lee
  • Ferenc Nagy
  • Zoltan Mate
  • T Oyama
  • James M Tepperman
  • Chitra Subramanian
  • Peter H Quail
  • Richard Sibout
  • Mi Kyung Yoon
  • Yong Sic Hwang
  • C S Hardtke
  • Yusuke Saijo
  • Bridey B Maxwell
  • K Okada
  • S Chattopadhyay
  • L H Ang
  • Wanqing Wang
  • Keunhwa Kim
  • Carlos D Crocco
  • Xin Wang

Detail Information

Publications63

  1. pmc Integration of light and abscisic acid signaling during seed germination and early seedling development
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Proc Natl Acad Sci U S A 105:4495-500. 2008
    ..Here, we found that the previously described light-signaling component HY5 also mediates ABA response in seed germination, early seedling growth, and root development in Arabidopsis...
  2. pmc HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression
    Bridey B Maxwell
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Plant Physiol 133:1565-77. 2003
    ..b>HY5, a factor that binds CAB upstream factor-1, is also required for DET1 effects in the light...
  3. ncbi Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development
    L H Ang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell 1:213-22. 1998
    ..Here, we show that COP1 negatively regulates HY5, a bZIP protein and a positive regulator of photomorphogenic development...
  4. pmc Opposite root growth phenotypes of hy5 versus hy5 hyh mutants correlate with increased constitutive auxin signaling
    Richard Sibout
    Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 2:e202. 2006
    The Arabidopsis transcription factor HY5 controls light-induced gene expression downstream of photoreceptors and plays an important role in the switch of seedling shoots from dark-adapted to light-adapted development...
  5. pmc Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development
    Ritu Kushwaha
    National Institute for Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    Plant Cell 20:1747-59. 2008
    ..However, cam7 mutants display reduced expression of light-inducible genes, and cam7 hy5 double mutants show an enhancement of the hy5 phenotype...
  6. doi The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1
    Else M Jonassen
    University of Stavanger, Centre for Organelle Research, Faculty of Science and Technology, N 4036 Stavanger, Norway
    J Plant Physiol 166:2071-6. 2009
    ..was impaired in Arabidopsis seedlings and rosette stage leaves when the basic leucine zipper transcription factors HY5 and HYH were absent...
  7. pmc Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1
    M Holm
    Department of Molecular, Cellular and Developmental Biology, Yale University, OML 354, Yale University, PO Box 20 8104, 165 Prospect Street, New Haven, CT 06520 8104, USA
    EMBO J 20:118-27. 2001
    ..COP1 is a photomorphogenesis repressor capable of directly interacting with the photomorphogenesis-promoting factor HY5. This interaction between HY5 and COP1 results in targeted deg radation of HY5 by the 26S proteasome...
  8. pmc Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis
    Magnus Holm
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8104, USA
    Genes Dev 16:1247-59. 2002
    ..It was shown that in the dark, COP1 directly interacts with the bZIP transcription factor HY5, a positive regulator of photomorphogenesis, and promotes its proteasome-mediated degradation...
  9. pmc HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain
    C S Hardtke
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    EMBO J 19:4997-5006. 2000
    Arabidopsis HY5 is a bZIP transcription factor that promotes photomorphogenesis...
  10. pmc Arabidopsis bZIP protein HY5 directly interacts with light-responsive promoters in mediating light control of gene expression
    S Chattopadhyay
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Plant Cell 10:673-83. 1998
    The Arabidopsis HY5 gene has been defined genetically as a positive regulator of photomorphogenesis and recently has been shown to encode a basic leucine zipper type of transcription factor...
  11. doi KAI2- and MAX2-mediated responses to karrikins and strigolactones are largely independent of HY5 in Arabidopsis seedlings
    Mark T Waters
    Plant Energy Biology, University of Western Australia, Crawley, Western Australia 6009, Australia
    Mol Plant 6:63-75. 2013
    ..Both MAX2 and KAI2 are essential for normal light-dependent seedling development. The bZIP transcription factor HY5 acts downstream of multiple photoreceptors and promotes photomorphogenesis, but its relationship with ..
  12. pmc Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis
    Dongqin Chen
    Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Plant Cell 25:1657-73. 2013
    ..helix-loop-helix and bZIP transcription factors PHYTOCHROME-INTERACTING FACTOR1 (PIF1), PIF3, ELONGATED HYPOCOTYL5 (HY5), and HY5 HOMOLOGY (HYH) that bridge light and ROS signaling to regulate cell death and photooxidative response...
  13. doi The key enzyme of sulfate assimilation, adenosine 5'-phosphosulfate reductase, is regulated by HY5 in Arabidopsis
    Bok Rye Lee
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
    Plant J 67:1042-54. 2011
    ..a genetic screen for mutants lacking this regulation, we identified the bZIP transcription factor LONG HYPOCOTYL 5 (HY5) as a necessary component of the regulatory circuit...
  14. doi The ethylene response factor AtERF11 that is transcriptionally modulated by the bZIP transcription factor HY5 is a crucial repressor for ethylene biosynthesis in Arabidopsis
    Zhuofu Li
    Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Plant J 68:88-99. 2011
    ..In this work ABA-responsive mutants were screened and a bZIP transcription factor HY5 was identified as a negative regulator of ethylene biosynthesis via modulation of the expression of ..
  15. doi Genome-wide mapping of the HY5-mediated gene networks in Arabidopsis that involve both transcriptional and post-transcriptional regulation
    Huiyong Zhang
    Peking Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, School of Life Sciences, Peking University, Beijing 100871, China
    Plant J 65:346-58. 2011
    LONG HYPOCOTYL 5 (HY5) is a basic leucine zipper transcription factor (TF) that functions downstream of multiple families of photoreceptors...
  16. doi Both HY5 and HYH are necessary regulators for low temperature-induced anthocyanin accumulation in Arabidopsis seedlings
    Yongqiang Zhang
    Key Laboratory of Arid and Grassland Agroecology Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou Gansu, People s Republic of China
    J Plant Physiol 168:367-74. 2011
    The roles of two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) in inducing anthocyanin accumulation during low temperature treatment were studied in Arabidopsis...
  17. doi Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation
    Qiu Ming Shi
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, 200032 Shanghai, PR China
    Mol Plant 4:1092-104. 2011
    ..Interestingly, MSBP1 expression is greatly suppressed in hy5, hyh, or hy5 hyh mutants but enhanced in cop1 mutants...
  18. doi Repression of shade-avoidance reactions by sunfleck induction of HY5 expression in Arabidopsis
    Romina Sellaro
    IFEVA, Facultad de Agronomia, Universidad de Buenos Aires and Consejo Nacional de Investigaciones Científicas y Técnicas, 1417 Buenos Aires, Argentina
    Plant J 68:919-28. 2011
    ..By using forward and reverse genetic approaches we found that ELONGATED HYPOCOTYL 5, LATE ELONGATED HYPOCOTYL, PHYTOCHROME KINASE SUBSTRATE 4 and auxin signalling are key players in this ..
  19. doi Interplay between Heat Shock Protein 90 and HY5 controls PhANG expression in response to the GUN5 plastid signal
    Peter Kindgren
    Umea Plant Science Centre, Department of Plant Physiology, Umea University, Umea, Sweden
    Mol Plant 5:901-13. 2012
    ..We also show that the hy5 mutant is insensitive to tetrapyrrole accumulation and that Mg-ProtoIX, cytosolic HSP90, and HY5 are all part of ..
  20. pmc The mediator complex subunit PFT1 interferes with COP1 and HY5 in the regulation of Arabidopsis light signaling
    Cornelia Klose
    Albert Ludwigs Universitat Freiburg, Faculty of Biology, Institut für Biologie 2, Botanik, 79104 Freiburg, Germany
    Plant Physiol 160:289-307. 2012
    ..Our data further indicate that PFT1 regulates the floral transition downstream of phyA. The PFT1 missense mutation seems to create a constitutively active transcription factor by mimicking an early step in light signaling...
  21. pmc Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity
    Lei Jiang
    Key Laboratory of Ecology and Environmental Science in Guangdong Higher Education, School of Life Science, South China Normal University, Guangzhou, Guangdong 510631, China
    Cell Res 22:1046-57. 2012
    ..which include UVR8 (a UV-B-specific photoreceptor), COP1 (a WD40-repeat-containing RING finger protein), HY5 (a basic zipper transcription factor), and RUP1/2 (two UVR8-interacting proteins)...
  22. pmc Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development
    Babu Rajendra V Prasad
    National Institute of Plant Genome Research, New Delhi, India
    BMC Plant Biol 12:37. 2012
    ..Arabidopsis HY1/HO1 is a rate-limiting enzyme involved in biosynthesis of phytochrome chromophore. HY5 (a bZIP protein) promotes photomorphogenesis, however ZBF1/MYC2 (a bHLH protein) works as a negative regulator of ..
  23. doi HY5 regulates anthocyanin biosynthesis by inducing the transcriptional activation of the MYB75/PAP1 transcription factor in Arabidopsis
    Dong Ho Shin
    Department of Biological Sciences, Chungnam National University, Daejeon 305 764, Republic of Korea
    FEBS Lett 587:1543-7. 2013
    Several positive transcription factors regulate Arabidopsis anthocyanin biosynthesis. HY5, a component of light-signaling pathways, and PAP1, an R2R3-MYB transcription factor, share common regulatory targets on anthocyanin biosynthesis ..
  24. doi Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis
    Alexander Maier
    Botanical Institute and Cluster of Excellence on Plant Sciences CEPLAS, University of Cologne, Biocenter, Zülpicher Str 47b, 50674, Cologne, Germany
    Plant J 74:638-51. 2013
    ..Thus, our findings have identified mechanisms via which the COP1/SPA complex controls anthocyanin levels in Arabidopsis that may be useful for applications in biotechnology directed towards increasing anthocyanin content in plants...
  25. pmc The Arabidopsis B-BOX protein BBX25 interacts with HY5, negatively regulating BBX22 expression to suppress seedling photomorphogenesis
    Sreeramaiah N Gangappa
    Department of Biological and Environmental Sciences, Gothenburg University, Gothenburg SE 40530, Sweden
    Plant Cell 25:1243-57. 2013
    ELONGATED HYPOCOTYL5 (HY5) is a basic domain/leucine zipper (bZIP) transcription factor, central for the regulation of seedling photomorphogenesis...
  26. pmc Arabidopsis chromatin remodeling factor PICKLE interacts with transcription factor HY5 to regulate hypocotyl cell elongation
    Yanjun Jing
    Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Plant Cell 25:242-56. 2013
    ..Furthermore, we reveal that the transcription factor ELONGATED HYPOCOTYL5 (HY5) binds to the promoters of cell elongation-related genes and recruits PKL/EPP1 through their physical interaction...
  27. pmc Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription in response to photomorphogenic UV-B light
    Xi Huang
    College of Life Sciences, Beijing Normal University, Beijing 100875, China
    Plant Cell 24:4590-606. 2012
    ..Two transcription factors, FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and ELONGATED HYPOCOTYL5 (HY5), directly bind to distinct regulatory elements within the COP1 promoter, which are essential for the induction of ..
  28. pmc Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana
    Aparna Singh
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, 10067 New Delhi, India
    J Biol Chem 287:25995-6009. 2012
    ..Whereas the bZIP proteins, HY5 (elongated hypocotyl 5) and HYH (HY5 homologue), are degraded by COP1-mediated proteasomal pathways, GBF1 is degraded by a ..
  29. pmc Phosphorylation of FAR-RED ELONGATED HYPOCOTYL1 is a key mechanism defining signaling dynamics of phytochrome A under red and far-red light in Arabidopsis
    Fang Chen
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Conecticut 06520, USA
    Plant Cell 24:1907-20. 2012
    ..Collectively, our results reveal FHY1 phosphorylation as a key mechanism for FR/R spectrum-specific responses in plants and an essential event for plant adaption to changing light conditions in nature...
  30. pmc Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner
    Yongqiang Zhang
    School of Life Sciences, Lanzhou University, Lanzhou Gansu, China
    Plant Signal Behav 6:632-4. 2011
    ..Recently, two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HOMOLOG OF HY5 (HYH) were identified to play an important role in the process of low temperature-induced ..
  31. pmc Plastid signals remodel light signaling networks and are essential for efficient chloroplast biogenesis in Arabidopsis
    Michael E Ruckle
    Michigan State University Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 19:3944-60. 2007
    ..At least part of this remodeling of light signaling networks involves converting HY5, a positive regulator of PhANGs, into a negative regulator of PhANGs...
  32. pmc Arabidopsis transcription factor ELONGATED HYPOCOTYL5 plays a role in the feedback regulation of phytochrome A signaling
    Jigang Li
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Plant Cell 22:3634-49. 2010
    ..Here, we report that ELONGATED HYPOCOTYL5 (HY5), a well-characterized bZIP transcription factor involved in promoting photomorphogenesis, directly binds ACGT-..
  33. pmc CONSTANS and ASYMMETRIC LEAVES 1 complex is involved in the induction of FLOWERING LOCUS T in photoperiodic flowering in Arabidopsis
    Young Hun Song
    Division of Applied Life Science BK21 program, Plant Molecular Biology and Biotechnology Research Center, Graduate School of Gyeongsang National University, Jinju 660 701, Korea
    Plant J 69:332-42. 2012
    ..These results indicate that CO forms a functional complex with AS1 to regulate FT expression and that AS1 plays different roles in two regulatory pathways, both of which concomitantly regulate the precise timing of flowering...
  34. pmc Genetic interaction of two abscisic acid signaling regulators, HY5 and FIERY1, in mediating lateral root formation
    Hao Chen
    Donald Danforth Plant Science Center, St Louis, MO, USA
    Plant Signal Behav 6:123-5. 2011
    ..hypersensitivity to ABA in lateral root growth, are opposite to those of another light- and ABA-signaling mutant, hy5. Here we analyzed the hy5 fry1 double mutant for root and hypocotyl growth...
  35. doi Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis
    Gang Li
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nat Cell Biol 13:616-22. 2011
    ..Here, we show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive regulators of the phytochrome A signalling pathway, directly bind to the promoter of ELF4, a ..
  36. pmc Functional profiling reveals that only a small number of phytochrome-regulated early-response genes in Arabidopsis are necessary for optimal deetiolation
    Rajnish Khanna
    Department of Plant and Microbial Biology, University of California, Berkeley, 94720, USA
    Plant Cell 18:2157-71. 2006
    ....
  37. pmc BBX32, an Arabidopsis B-Box protein, functions in light signaling by suppressing HY5-regulated gene expression and interacting with STH2/BBX21
    Hans E Holtan
    Mendel Biotechnology, Inc, Hayward, California 94545, USA
    Plant Physiol 156:2109-23. 2011
    ..profiling and growth curve studies, we demonstrate that BBX32 acts antagonistically to ELONGATED HYPOCOTYL5 (HY5)...
  38. doi HYPOSENSITIVE TO LIGHT, an alpha/beta fold protein, acts downstream of ELONGATED HYPOCOTYL 5 to regulate seedling de-etiolation
    Xiao Dong Sun
    Department of Plant Biology, University of Minnesota, St Paul, MN 55108, USA
    Mol Plant 4:116-26. 2011
    ..of HTL was strongly induced by light of various wavelengths and this light induction was impaired in elongated hypocotyl 5. HY5 directly bound to both a C/G-box and a G-box in the HTL promoter but with a greater affinity toward ..
  39. doi The role of phosphorylatable serine residues in the DNA-binding domain of Arabidopsis bZIP transcription factors
    Tobias Kirchler
    Center for Plant Molecular Biology ZMBP Plant Physiology, University of Tubingen, Auf der Morgenstelle 1, D 72076 Tubingen, Germany
    Eur J Cell Biol 89:175-83. 2010
    ..of these serines strongly interfere with the DNA binding of two prototypical Arabidopsis bZIPs, namely AtZIP63 and HY5. Our data suggest that the identified serines could serve as in vivo targets for kinases and phosphatases, allowing ..
  40. pmc Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development
    Jungeun Lee
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Conecticut 06520 8104, USA
    Plant Cell 19:731-49. 2007
    The transcription factor LONG HYPOCOTYL5 (HY5) acts downstream of multiple families of the photoreceptors and promotes photomorphogenesis...
  41. ncbi PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis
    Jieun Shin
    Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
    Plant J 49:981-94. 2007
    ..Here we investigated the functional relationship between two such transcription factors, PIF3 and HY5, and their effects on anthocyanin biosynthesis...
  42. ncbi phyA dominates in transduction of red-light signals to rapidly responding genes at the initiation of Arabidopsis seedling de-etiolation
    James M Tepperman
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant J 48:728-42. 2006
    ....
  43. ncbi Intrinsically unstructured N-terminal domain of bZIP transcription factor HY5
    Mi Kyung Yoon
    Department of Chemistry and National Creative Research Initiative Center, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejon 305 701, Republic of Korea
    Proteins 65:856-66. 2006
    The Arabidopsis HY5 protein is a basic leucine zipper (bZIP) transcription factor that promotes photomorphogenesis...
  44. ncbi A suite of tools and application notes for in vivo protein interaction assays using bioluminescence resonance energy transfer (BRET)
    Chitra Subramanian
    Department of Biochemistry, Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN 37996 0840, USA
    Plant J 48:138-52. 2006
    ..between COP1 and the B-box protein STH, and interaction between the light regulatory bZip transcription factors HY5 and HYH. A codon-optimized version of the Renilla luciferase gene resulted in improved expression in Arabidopsis...
  45. pmc CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis
    Attila Oravecz
    Institute of Biology II Botany, University of Freiburg, D 79104 Freiburg, Germany
    Plant Cell 18:1975-90. 2006
    ..Among its substrates is the basic domain/leucine zipper (bZIP) transcription factor ELONGATED HYPOCOTYL5 (HY5), one of the key regulators of photomorphogenesis under all light qualities, including UV-B responses required for ..
  46. pmc Genome-wide analysis of gene expression reveals function of the bZIP transcription factor HY5 in the UV-B response of Arabidopsis
    Roman Ulm
    Institute of Biology II Botany, University of Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 101:1397-402. 2004
    ..Finally, we demonstrate that the bZIP transcription factor HY5 is required for UV-B-mediated regulation of a subset of genes.
  47. pmc The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity
    Yusuke Saijo
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 17:2642-7. 2003
    ..is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation...
  48. ncbi Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8)
    Christian S Hardtke
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Plant J 30:385-94. 2002
    Arabidopsis COP1 is a negative regulator of photomorphogenesis, which targets HY5, a positive regulator of photomorphogenesis, for degradation via the proteasome pathway in the absence of light...
  49. ncbi A genomic perspective on plant transcription factors
    J L Riechmann
    Mendel Biotechnology, Hayward, California 94545, USA
    Curr Opin Plant Biol 3:423-34. 2000
    ....
  50. ncbi HY5 and HYH are positive regulators of nitrate reductase in seedlings and rosette stage plants
    Else Müller Jonassen
    Department of Mathematics and Natural Science, University of Stavanger, 4036 Stavanger, Norway
    Planta 227:559-64. 2008
    b>HY5 and HYH are bZIP transcription factors well known to be involved in photomorphogenesis and light signalling...
  51. ncbi Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling de-etiolation in darkness
    David Alabadi
    Instituto de Biología Molecular y Celular de Plantas CSIC UPV, Av De Los Naranjos s n, 46022 Valencia, Spain
    Plant J 53:324-35. 2008
    ..which induces proteolytic degradation of transcription factors necessary for light-regulated development, such as HY5 (LONG HYPOCOTYL 5) and HYH (LONG HYPOCOTYL 5 HOMOLOG), and stabilization of transcription factors that promote ..
  52. doi SPA1 and DET1 act together to control photomorphogenesis throughout plant development
    Markus Nixdorf
    Botanical Institute, University of Cologne, Otto Fischer Str 6, 50674, Cologne, Germany
    Planta 231:825-33. 2010
    ..On the biochemical level, the det1 ( esp1 ) spa1 double mutant showed higher HY5 protein levels than either single mutant or the wild type...
  53. doi The Arabidopsis bZIP transcription factor HY5 regulates expression of the PFG1/MYB12 gene in response to light and ultraviolet-B radiation
    Ralf Stracke
    Department of Biology, Chair of Genome Research, Bielefeld University, Bielefeld, Germany
    Plant Cell Environ 33:88-103. 2010
    ..We further show that the bZIP transcriptional regulator ELONGATED HYPOCOTYL5 (HY5) is required for the transcriptional activation of the PFG1/MYB12 and PFG3/MYB111 genes under UV-B and visible ..
  54. doi UV-B action spectrum for UVR8-mediated HY5 transcript accumulation in Arabidopsis
    Bobby A Brown
    Plant Science Group, Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Photochem Photobiol 85:1147-55. 2009
    ..It is required for UV-B-induced expression of the gene encoding the ELONGATED HYPOCOTYL5 (HY5) transcription factor. HY5 is a key effector of responses mediated by UVR8...
  55. pmc LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination
    Sourav Datta
    Department of Cell and Molecular Biology, Gothenburg University, 405 30 Gothenburg, Sweden
    Plant Cell 20:2324-38. 2008
    ..a B-box encoding gene that genetically interacts with two key regulators of light signaling, ELONGATED HYPOCOTYL5 (HY5) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)...
  56. doi Identification of a novel cis-regulatory element for UV-B-induced transcription in Arabidopsis
    Judit Safrany
    Agricultural Biotechnology Center, Szent Gyorgyi A 4, H 2100 Godollo, Hungary
    Plant J 54:402-14. 2008
    ..LOCUS 8 (UVR 8) mediates responsiveness to longer wavelength, low intensity UV-B light-activating, for example, HY5 gene expression...
  57. pmc Light induces peroxisome proliferation in Arabidopsis seedlings through the photoreceptor phytochrome A, the transcription factor HY5 HOMOLOG, and the peroxisomal protein PEROXIN11b
    Mintu Desai
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Plant Physiol 146:1117-27. 2008
    ..The far-red light receptor phytochrome A (phyA) and the bZIP transcription factor HY5 HOMOLOG (HYH) are both required for the up-regulation of PEX11b in the light...
  58. doi LZF1, a HY5-regulated transcriptional factor, functions in Arabidopsis de-etiolation
    Chiung swey Joanne Chang
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, Taiwan
    Plant J 54:205-19. 2008
    ..gene expression patterns during early photomorphogenesis in both wild-type and mutant Arabidopsis defective in HY5, an influential positive regulator of the responses of gene expression to a light stimulus, to identify light-..
  59. ncbi Arabidopsis HY5 protein functions as a DNA-binding tag for purification and functional immobilization of proteins on agarose/DNA microplate
    Tatsuya Sawasaki
    Cell Free Science and Technology Research Center, and The Venture Business Laboratory, Ehime University, Matsuyama, Ehime, Japan
    FEBS Lett 582:221-8. 2008
    ..Here, we report that the Arabidopsis HY5 functions as a novel DNA-binding tag (DBtag) for proteins...
  60. pmc UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH
    Bobby A Brown
    Plant Science Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Plant Physiol 146:576-88. 2008
    ..Genes encoding the ELONGATED HYPOCOTYL5 (HY5) and HY5 HOMOLOG (HYH) transcription factors are induced at low UV-B fluence rates (0.1 micromol m(-2) s(-1))...
  61. pmc Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development
    K U Torii
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208104, 165 Prospect Street, OML 301, New Haven, CT 06520 8104, USA
    EMBO J 17:5577-87. 1998
    ..repression can be at least in part accounted for by COP1's direct interaction with and negative regulation of HY5, a bZIP transcription factor that positively regulates photomorphogenesis...
  62. pmc The Arabidopsis HY5 gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl
    T Oyama
    Department of Botany, Graduate School of Science, Kyoto University, Kyoto 606 01, Japan
    Genes Dev 11:2983-95. 1997
    ..As a photomorphogenetic mutant, hy5 of Arabidopsis has been isolated and characterized...
  63. ncbi The COP/DET/FUS proteins-regulators of eukaryotic growth and development
    C Schwechheimer
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8104, USA
    Semin Cell Dev Biol 11:495-503. 2000
    ..In the dark, COP1 accumulates in the nucleus where it is required for the degradation of the HY5 protein, a positive regulator of photomorphogenesis...