Gene Symbol: HY5
Description: Basic-leucine zipper (bZIP) transcription factor family protein
Alias: BZIP TRANSCRIPTION FACTOR HY5, ELONGATED HYPOCOTYL 5, F2I11.150, F2I11_150, REVERSAL OF THE DET PHENOTYPE 5, TED 5, Basic-leucine zipper (bZIP) transcription factor family protein
Species: thale cress
Products:     HY5

Top Publications

  1. Chen H, Zhang J, Neff M, Hong S, Zhang H, Deng X, et al. Integration of light and abscisic acid signaling during seed germination and early seedling development. Proc Natl Acad Sci U S A. 2008;105:4495-500 pubmed publisher
    ..Here, we found that the previously described light-signaling component HY5 also mediates ABA response in seed germination, early seedling growth, and root development in Arabidopsis...
  2. Hardtke C, Gohda K, Osterlund M, Oyama T, Okada K, Deng X. HY5 stability and activity in arabidopsis is regulated by phosphorylation in its COP1 binding domain. EMBO J. 2000;19:4997-5006 pubmed
    Arabidopsis HY5 is a bZIP transcription factor that promotes photomorphogenesis...
  3. Ang L, Chattopadhyay S, Wei N, Oyama T, Okada K, Batschauer A, et al. Molecular interaction between COP1 and HY5 defines a regulatory switch for light control of Arabidopsis development. Mol Cell. 1998;1:213-22 pubmed
    ..Here, we show that COP1 negatively regulates HY5, a bZIP protein and a positive regulator of photomorphogenic development...
  4. Chen D, Xu G, Tang W, Jing Y, Ji Q, Fei Z, et al. Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis. Plant Cell. 2013;25:1657-73 pubmed publisher
    ..helix-loop-helix and bZIP transcription factors PHYTOCHROME-INTERACTING FACTOR1 (PIF1), PIF3, ELONGATED HYPOCOTYL5 (HY5), and HY5 HOMOLOGY (HYH) that bridge light and ROS signaling to regulate cell death and photooxidative response...
  5. Zhang Y, Zheng S, Liu Z, Wang L, Bi Y. Both HY5 and HYH are necessary regulators for low temperature-induced anthocyanin accumulation in Arabidopsis seedlings. J Plant Physiol. 2011;168:367-74 pubmed publisher
    The roles of two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HY5 HOMOLOG (HYH) in inducing anthocyanin accumulation during low temperature treatment were studied in Arabidopsis...
  6. Holm M, Ma L, Qu L, Deng X. Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Genes Dev. 2002;16:1247-59 pubmed
    ..It was shown that in the dark, COP1 directly interacts with the bZIP transcription factor HY5, a positive regulator of photomorphogenesis, and promotes its proteasome-mediated degradation...
  7. Zhang Y, Liu Z, Liu R, Hao H, Bi Y. Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner. Plant Signal Behav. 2011;6:632-4 pubmed
    ..Recently, two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HOMOLOG OF HY5 (HYH) were identified to play an important role in the process of low temperature-induced ..
  8. Shin J, Park E, Choi G. PIF3 regulates anthocyanin biosynthesis in an HY5-dependent manner with both factors directly binding anthocyanin biosynthetic gene promoters in Arabidopsis. Plant J. 2007;49:981-94 pubmed
    ..Here we investigated the functional relationship between two such transcription factors, PIF3 and HY5, and their effects on anthocyanin biosynthesis...
  9. Kushwaha R, Singh A, Chattopadhyay S. Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development. Plant Cell. 2008;20:1747-59 pubmed publisher
    ..However, cam7 mutants display reduced expression of light-inducible genes, and cam7 hy5 double mutants show an enhancement of the hy5 phenotype...

More Information


  1. Zhang H, He H, Wang X, Wang X, Yang X, Li L, et al. Genome-wide mapping of the HY5-mediated gene networks in Arabidopsis that involve both transcriptional and post-transcriptional regulation. Plant J. 2011;65:346-58 pubmed publisher
    LONG HYPOCOTYL 5 (HY5) is a basic leucine zipper transcription factor (TF) that functions downstream of multiple families of photoreceptors...
  2. Lee J, He K, Stolc V, Lee H, Figueroa P, Gao Y, et al. Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development. Plant Cell. 2007;19:731-49 pubmed
    The transcription factor LONG HYPOCOTYL5 (HY5) acts downstream of multiple families of the photoreceptors and promotes photomorphogenesis...
  3. Desai M, Hu J. Light induces peroxisome proliferation in Arabidopsis seedlings through the photoreceptor phytochrome A, the transcription factor HY5 HOMOLOG, and the peroxisomal protein PEROXIN11b. Plant Physiol. 2008;146:1117-27 pubmed publisher
    ..The far-red light receptor phytochrome A (phyA) and the bZIP transcription factor HY5 HOMOLOG (HYH) are both required for the up-regulation of PEX11b in the light...
  4. Saijo Y, Sullivan J, Wang H, Yang J, Shen Y, Rubio V, et al. The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity. Genes Dev. 2003;17:2642-7 pubmed
    ..is a constitutive repressor of photomorphogenesis that interacts with photomorphogenesis-promoting factors such as HY5 to promote their proteasome-mediated degradation...
  5. Holm M, Hardtke C, Gaudet R, Deng X. Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. EMBO J. 2001;20:118-27 pubmed
    ..COP1 is a photomorphogenesis repressor capable of directly interacting with the photomorphogenesis-promoting factor HY5. This interaction between HY5 and COP1 results in targeted deg radation of HY5 by the 26S proteasome...
  6. Andronis C, Barak S, Knowles S, Sugano S, Tobin E. The clock protein CCA1 and the bZIP transcription factor HY5 physically interact to regulate gene expression in Arabidopsis. Mol Plant. 2008;1:58-67 pubmed publisher
    ..In close proximity to this sequence, there exists a G-box core element that has been shown to bind the bZIP transcription factor HY5 in other light-regulated plant promoters...
  7. Datta S, Johansson H, Hettiarachchi C, Irigoyen M, Desai M, Rubio V, et al. LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination. Plant Cell. 2008;20:2324-38 pubmed publisher
    ..a B-box encoding gene that genetically interacts with two key regulators of light signaling, ELONGATED HYPOCOTYL5 (HY5) and CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)...
  8. Toledo Ortiz G, Johansson H, Lee K, Bou Torrent J, Stewart K, Steel G, et al. The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription. PLoS Genet. 2014;10:e1004416 pubmed publisher
    ..While the bZIP transcription factor long hypocotyl 5 (HY5), a potent PIF antagonist, promotes photosynthetic pigment accumulation in response to light...
  9. Alabadi D, Gallego Bartolome J, Orlando L, García Cárcel L, Rubio V, Martinez C, et al. Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling de-etiolation in darkness. Plant J. 2008;53:324-35 pubmed
    ..which induces proteolytic degradation of transcription factors necessary for light-regulated development, such as HY5 (LONG HYPOCOTYL 5) and HYH (LONG HYPOCOTYL 5 HOMOLOG), and stabilization of transcription factors that promote ..
  10. Oyama T, Shimura Y, Okada K. The Arabidopsis HY5 gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl. Genes Dev. 1997;11:2983-95 pubmed
    ..As a photomorphogenetic mutant, hy5 of Arabidopsis has been isolated and characterized...
  11. Li Z, Zhang L, Yu Y, Quan R, Zhang Z, Zhang H, et al. The ethylene response factor AtERF11 that is transcriptionally modulated by the bZIP transcription factor HY5 is a crucial repressor for ethylene biosynthesis in Arabidopsis. Plant J. 2011;68:88-99 pubmed publisher
    ..In this work ABA-responsive mutants were screened and a bZIP transcription factor HY5 was identified as a negative regulator of ethylene biosynthesis via modulation of the expression of ..
  12. Jing Y, Zhang D, Wang X, Tang W, Wang W, Huai J, et al. Arabidopsis chromatin remodeling factor PICKLE interacts with transcription factor HY5 to regulate hypocotyl cell elongation. Plant Cell. 2013;25:242-56 pubmed publisher
    ..Furthermore, we reveal that the transcription factor ELONGATED HYPOCOTYL5 (HY5) binds to the promoters of cell elongation-related genes and recruits PKL/EPP1 through their physical interaction...
  13. Chattopadhyay S, Ang L, Puente P, Deng X, Wei N. Arabidopsis bZIP protein HY5 directly interacts with light-responsive promoters in mediating light control of gene expression. Plant Cell. 1998;10:673-83 pubmed
    The Arabidopsis HY5 gene has been defined genetically as a positive regulator of photomorphogenesis and recently has been shown to encode a basic leucine zipper type of transcription factor...
  14. Subramanian C, Woo J, Cai X, Xu X, Servick S, Johnson C, et al. A suite of tools and application notes for in vivo protein interaction assays using bioluminescence resonance energy transfer (BRET). Plant J. 2006;48:138-52 pubmed
    ..between COP1 and the B-box protein STH, and interaction between the light regulatory bZip transcription factors HY5 and HYH. A codon-optimized version of the Renilla luciferase gene resulted in improved expression in Arabidopsis...
  15. Sibout R, Sukumar P, Hettiarachchi C, Holm M, Muday G, Hardtke C. Opposite root growth phenotypes of hy5 versus hy5 hyh mutants correlate with increased constitutive auxin signaling. PLoS Genet. 2006;2:e202 pubmed
    The Arabidopsis transcription factor HY5 controls light-induced gene expression downstream of photoreceptors and plays an important role in the switch of seedling shoots from dark-adapted to light-adapted development...
  16. Torii K, McNellis T, Deng X. Functional dissection of Arabidopsis COP1 reveals specific roles of its three structural modules in light control of seedling development. EMBO J. 1998;17:5577-87 pubmed
    ..repression can be at least in part accounted for by COP1's direct interaction with and negative regulation of HY5, a bZIP transcription factor that positively regulates photomorphogenesis...
  17. Chang C, Li Y, Chen L, Chen W, Hsieh W, Shin J, et al. LZF1, a HY5-regulated transcriptional factor, functions in Arabidopsis de-etiolation. Plant J. 2008;54:205-19 pubmed publisher
    ..gene expression patterns during early photomorphogenesis in both wild-type and mutant Arabidopsis defective in HY5, an influential positive regulator of the responses of gene expression to a light stimulus, to identify light-..
  18. Waters M, Smith S. KAI2- and MAX2-mediated responses to karrikins and strigolactones are largely independent of HY5 in Arabidopsis seedlings. Mol Plant. 2013;6:63-75 pubmed publisher
    ..Both MAX2 and KAI2 are essential for normal light-dependent seedling development. The bZIP transcription factor HY5 acts downstream of multiple photoreceptors and promotes photomorphogenesis, but its relationship with ..
  19. Xu X, Paik I, Zhu L, Bu Q, Huang X, Deng X, et al. PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis. Plant Cell. 2014;26:1992-2006 pubmed
    ..LONG HYPOCOTYL5 (HY5) is stabilized in the cop1 pif1, spa123 pif1, and pif double, triple, and quadruple mutants in the dark...
  20. Kindgren P, Norén L, López J, Shaikhali J, Strand A. Interplay between Heat Shock Protein 90 and HY5 controls PhANG expression in response to the GUN5 plastid signal. Mol Plant. 2012;5:901-13 pubmed publisher
    ..We also show that the hy5 mutant is insensitive to tetrapyrrole accumulation and that Mg-ProtoIX, cytosolic HSP90, and HY5 are all part of ..
  21. Li G, Siddiqui H, Teng Y, Lin R, Wan X, Li J, et al. Coordinated transcriptional regulation underlying the circadian clock in Arabidopsis. Nat Cell Biol. 2011;13:616-22 pubmed publisher
    ..Here, we show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive regulators of the phytochrome A signalling pathway, directly bind to the promoter of ELF4, a ..
  22. Stracke R, Favory J, Gruber H, Bartelniewoehner L, Bartels S, Binkert M, et al. The Arabidopsis bZIP transcription factor HY5 regulates expression of the PFG1/MYB12 gene in response to light and ultraviolet-B radiation. Plant Cell Environ. 2010;33:88-103 pubmed publisher
    ..We further show that the bZIP transcriptional regulator ELONGATED HYPOCOTYL5 (HY5) is required for the transcriptional activation of the PFG1/MYB12 and PFG3/MYB111 genes under UV-B and visible ..
  23. Ruckle M, DeMarco S, Larkin R. Plastid signals remodel light signaling networks and are essential for efficient chloroplast biogenesis in Arabidopsis. Plant Cell. 2007;19:3944-60 pubmed
    ..At least part of this remodeling of light signaling networks involves converting HY5, a positive regulator of PhANGs, into a negative regulator of PhANGs...
  24. Li Q, He J. BZR1 Interacts with HY5 to Mediate Brassinosteroid- and Light-Regulated Cotyledon Opening in Arabidopsis in Darkness. Mol Plant. 2016;9:113-125 pubmed publisher
    ..pathways, which was mediated by the BR-regulated transcription factor BZR1 and light-regulated transcription factor HY5 in Arabidopsis thaliana...
  25. Holtan H, Bandong S, Marion C, Adam L, Tiwari S, Shen Y, et al. BBX32, an Arabidopsis B-Box protein, functions in light signaling by suppressing HY5-regulated gene expression and interacting with STH2/BBX21. Plant Physiol. 2011;156:2109-23 pubmed publisher
    ..profiling and growth curve studies, we demonstrate that BBX32 acts antagonistically to ELONGATED HYPOCOTYL5 (HY5)...
  26. Jonassen E, Lea U, Lillo C. HY5 and HYH are positive regulators of nitrate reductase in seedlings and rosette stage plants. Planta. 2008;227:559-64 pubmed
    b>HY5 and HYH are bZIP transcription factors well known to be involved in photomorphogenesis and light signalling...
  27. Prasad B, Kumar S, Nandi A, Chattopadhyay S. Functional interconnections of HY1 with MYC2 and HY5 in Arabidopsis seedling development. BMC Plant Biol. 2012;12:37 pubmed publisher
    ..Arabidopsis HY1/HO1 is a rate-limiting enzyme involved in biosynthesis of phytochrome chromophore. HY5 (a bZIP protein) promotes photomorphogenesis, however ZBF1/MYC2 (a bHLH protein) works as a negative regulator of ..
  28. Pacín M, Legris M, Casal J. Rapid decline in nuclear costitutive photomorphogenesis1 abundance anticipates the stabilization of its target elongated hypocotyl5 in the light. Plant Physiol. 2014;164:1134-8 pubmed publisher
  29. Brown B, Headland L, Jenkins G. UV-B action spectrum for UVR8-mediated HY5 transcript accumulation in Arabidopsis. Photochem Photobiol. 2009;85:1147-55 pubmed publisher
    ..It is required for UV-B-induced expression of the gene encoding the ELONGATED HYPOCOTYL5 (HY5) transcription factor. HY5 is a key effector of responses mediated by UVR8...
  30. Chen H, Xiong L. Genetic interaction of two abscisic acid signaling regulators, HY5 and FIERY1, in mediating lateral root formation. Plant Signal Behav. 2011;6:123-5 pubmed
    ..hypersensitivity to ABA in lateral root growth, are opposite to those of another light- and ABA-signaling mutant, hy5. Here we analyzed the hy5 fry1 double mutant for root and hypocotyl growth...
  31. Shin D, Choi M, Kim K, Bang G, Cho M, Choi S, et al. HY5 regulates anthocyanin biosynthesis by inducing the transcriptional activation of the MYB75/PAP1 transcription factor in Arabidopsis. FEBS Lett. 2013;587:1543-7 pubmed publisher
    Several positive transcription factors regulate Arabidopsis anthocyanin biosynthesis. HY5, a component of light-signaling pathways, and PAP1, an R2R3-MYB transcription factor, share common regulatory targets on anthocyanin biosynthesis ..
  32. Tepperman J, Hwang Y, Quail P. phyA dominates in transduction of red-light signals to rapidly responding genes at the initiation of Arabidopsis seedling de-etiolation. Plant J. 2006;48:728-42 pubmed
  33. Yoon M, Shin J, Choi G, Choi B. Intrinsically unstructured N-terminal domain of bZIP transcription factor HY5. Proteins. 2006;65:856-66 pubmed
    The Arabidopsis HY5 protein is a basic leucine zipper (bZIP) transcription factor that promotes photomorphogenesis...
  34. Xu D, Lin F, Jiang Y, Huang X, Li J, Ling J, et al. The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings. Plant Cell. 2014;26:1981-1991 pubmed
    ..Therefore, we conclude that CSU1 plays a major role in maintaining COP1 homeostasis by targeting COP1 for ubiquitination and degradation in dark-grown seedlings. ..
  35. Abbas N, Maurya J, Senapati D, Gangappa S, Chattopadhyay S. Arabidopsis CAM7 and HY5 physically interact and directly bind to the HY5 promoter to regulate its expression and thereby promote photomorphogenesis. Plant Cell. 2014;26:1036-52 pubmed publisher
    ..The elongated HYPOCOTYL5 (HY5) bZIP protein, an integrator of multiple signaling pathways, also plays an important role in photomorphogenic ..
  36. Huang X, Ouyang X, Yang P, Lau O, Li G, Li J, et al. Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription in response to photomorphogenic UV-B light. Plant Cell. 2012;24:4590-606 pubmed publisher
    ..Two transcription factors, FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and ELONGATED HYPOCOTYL5 (HY5), directly bind to distinct regulatory elements within the COP1 promoter, which are essential for the induction of ..
  37. Singh A, Ram H, Abbas N, Chattopadhyay S. Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana. J Biol Chem. 2012;287:25995-6009 pubmed publisher
    ..Whereas the bZIP proteins, HY5 (elongated hypocotyl 5) and HYH (HY5 homologue), are degraded by COP1-mediated proteasomal pathways, GBF1 is degraded by a ..
  38. Sawasaki T, Kamura N, Matsunaga S, Saeki M, Tsuchimochi M, Morishita R, et al. Arabidopsis HY5 protein functions as a DNA-binding tag for purification and functional immobilization of proteins on agarose/DNA microplate. FEBS Lett. 2008;582:221-8 pubmed
    ..Here, we report that the Arabidopsis HY5 functions as a novel DNA-binding tag (DBtag) for proteins...
  39. He Z, Zhao X, Kong F, Zuo Z, Liu X. TCP2 positively regulates HY5/HYH and photomorphogenesis in Arabidopsis. J Exp Bot. 2016;67:775-85 pubmed publisher
    ..affected TCP2 expression in a wavelength-dependent manner and TCP2 positively regulates mRNA expression of HYH and HY5. These results support the hypothesis that TCP2 is a transcription activator which acts downstream of multiple ..
  40. Shi Q, Yang X, Song L, Xue H. Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation. Mol Plant. 2011;4:1092-104 pubmed publisher
    ..Interestingly, MSBP1 expression is greatly suppressed in hy5, hyh, or hy5 hyh mutants but enhanced in cop1 mutants...
  41. Schwechheimer C, Deng X. The COP/DET/FUS proteins-regulators of eukaryotic growth and development. Semin Cell Dev Biol. 2000;11:495-503 pubmed
    ..In the dark, COP1 accumulates in the nucleus where it is required for the degradation of the HY5 protein, a positive regulator of photomorphogenesis...
  42. Wang Y, Wang Y, Song Z, Zhang H. Repression of MYBL2 by Both microRNA858a and HY5 Leads to the Activation of Anthocyanin Biosynthetic Pathway in Arabidopsis. Mol Plant. 2016;9:1395-1405 pubmed publisher
    ..In addition, ELONGATED HYPOCOTYL 5 (HY5) was shown to directly bind the MYBL2 promoter and represses its expression via specific ..
  43. Binkert M, Kozma Bognár L, Terecskei K, De Veylder L, Nagy F, Ulm R. UV-B-responsive association of the Arabidopsis bZIP transcription factor ELONGATED HYPOCOTYL5 with target genes, including its own promoter. Plant Cell. 2014;26:4200-13 pubmed publisher
    ..The bZIP transcription factor ELONGATED HYPOCOTYL5 (HY5) acts downstream of the UV-B photoreceptor UV RESISTANCE LOCUS8 (UVR8) and promotes UV-B-induced photomorphogenesis ..
  44. Koprivova A, Calderwood A, Lee B, Kopriva S. Do PFT1 and HY5 interact in regulation of sulfate assimilation by light in Arabidopsis?. FEBS Lett. 2014;588:1116-21 pubmed publisher
    ..In addition, our data suggest a possible interplay of PFT1 with another transcription factor, HY5, in regulation of APS reductase by light.
  45. Chai T, Zhou J, Liu J, Xing D. LSD1 and HY5 antagonistically regulate red light induced-programmed cell death in Arabidopsis. Front Plant Sci. 2015;6:292 pubmed publisher
    ..In this study, lesion simulating disease1 (LSD1) and elongated hypocotyl 5 (HY5) perform opposite roles to regulate excess red light (RL)-triggered PCD associated with ROS and SA ..
  46. Maxwell B, Andersson C, Poole D, Kay S, Chory J. HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression. Plant Physiol. 2003;133:1565-77 pubmed
    ..b>HY5, a factor that binds CAB upstream factor-1, is also required for DET1 effects in the light...
  47. Feng X, Li J, Qi S, Lin Q, Jin J, Hua X. Light affects salt stress-induced transcriptional memory of P5CS1 in Arabidopsis. Proc Natl Acad Sci U S A. 2016;113:E8335-E8343 pubmed publisher
    ..Here we show that salinity-induced proline accumulation is memorable and HY5-dependent light signaling is required for such a memory response...
  48. Song Y, Lee I, Lee S, Imaizumi T, Hong J. CONSTANS and ASYMMETRIC LEAVES 1 complex is involved in the induction of FLOWERING LOCUS T in photoperiodic flowering in Arabidopsis. Plant J. 2012;69:332-42 pubmed publisher
    ..These results indicate that CO forms a functional complex with AS1 to regulate FT expression and that AS1 plays different roles in two regulatory pathways, both of which concomitantly regulate the precise timing of flowering. ..
  49. Hardtke C, Okamoto H, Stoop Myer C, Deng X. Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Plant J. 2002;30:385-94 pubmed
    Arabidopsis COP1 is a negative regulator of photomorphogenesis, which targets HY5, a positive regulator of photomorphogenesis, for degradation via the proteasome pathway in the absence of light...
  50. Zhang Y, Li C, Zhang J, Wang J, Yang J, Lv Y, et al. Dissection of HY5/HYH expression in Arabidopsis reveals a root-autonomous HY5-mediated photomorphogenic pathway. PLoS ONE. 2017;12:e0180449 pubmed publisher
    b>ELONGATED HYPOCOTYL 5 (HY5), a member of the bZIP gene family, is a positive regulator of the light signaling pathway in Arabidopsis thaliana...
  51. Yu Y, Wang J, Zhang Z, Quan R, Zhang H, Deng X, et al. Ethylene promotes hypocotyl growth and HY5 degradation by enhancing the movement of COP1 to the nucleus in the light. PLoS Genet. 2013;9:e1004025 pubmed publisher
    ..of constitutive photomorphogenesis 1 (COP1) to the nucleus where it mediates the degradation of long hypocotyl 5 (HY5), contributing to hypocotyl growth in the light...
  52. Khanna R, Shen Y, Toledo Ortiz G, Kikis E, Johannesson H, Hwang Y, et al. Functional profiling reveals that only a small number of phytochrome-regulated early-response genes in Arabidopsis are necessary for optimal deetiolation. Plant Cell. 2006;18:2157-71 pubmed
  53. Zhang H, Zhao X, Li J, Cai H, Deng X, Li L. MicroRNA408 is critical for the HY5-SPL7 gene network that mediates the coordinated response to light and copper. Plant Cell. 2014;26:4933-53 pubmed publisher
    ..to demonstrate an interaction between SQUAMOSA PROMOTER BINDING PROTEIN-LIKE7 (SPL7) and ELONGATED HYPOCOTYL5 (HY5), which mediate copper and light signaling, respectively...
  54. Chen X, Yao Q, Gao X, Jiang C, Harberd N, Fu X. Shoot-to-Root Mobile Transcription Factor HY5 Coordinates Plant Carbon and Nitrogen Acquisition. Curr Biol. 2016;26:640-6 pubmed publisher
    ..Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal ..
  55. Sun X, Ni M. HYPOSENSITIVE TO LIGHT, an alpha/beta fold protein, acts downstream of ELONGATED HYPOCOTYL 5 to regulate seedling de-etiolation. Mol Plant. 2011;4:116-26 pubmed publisher
    ..of HTL was strongly induced by light of various wavelengths and this light induction was impaired in elongated hypocotyl 5. HY5 directly bound to both a C/G-box and a G-box in the HTL promoter but with a greater affinity toward ..
  56. Kirchler T, Briesemeister S, Singer M, Schütze K, Keinath M, Kohlbacher O, et al. The role of phosphorylatable serine residues in the DNA-binding domain of Arabidopsis bZIP transcription factors. Eur J Cell Biol. 2010;89:175-83 pubmed publisher
    ..of these serines strongly interfere with the DNA binding of two prototypical Arabidopsis bZIPs, namely AtZIP63 and HY5. Our data suggest that the identified serines could serve as in vivo targets for kinases and phosphatases, allowing ..
  57. Nawkar G, Kang C, Maibam P, Park J, Jung Y, Chae H, et al. HY5, a positive regulator of light signaling, negatively controls the unfolded protein response in Arabidopsis. Proc Natl Acad Sci U S A. 2017;114:2084-2089 pubmed publisher
    ..Moreover, mutation of the ELONGATED HYPOCOTYL 5 (HY5), a key component of light signaling, leads to tolerance to ER stress...
  58. Srivastava A, Senapati D, Srivastava A, Chakraborty M, Gangappa S, Chattopadhyay S. Short Hypocotyl in White Light1 Interacts with Elongated Hypocotyl5 (HY5) and Constitutive Photomorphogenic1 (COP1) and Promotes COP1-Mediated Degradation of HY5 during Arabidopsis Seedling Development. Plant Physiol. 2015;169:2922-34 pubmed publisher
    ..Elongated Hypocotyl5 (HY5) is a photomorphogenesis promoting a basic leucine zipper transcription factor that is degraded by COP1 ubiquitin ..
  59. Zhang X, Huai J, Shang F, Xu G, Tang W, Jing Y, et al. A PIF1/PIF3-HY5-BBX23 Transcription Factor Cascade Affects Photomorphogenesis. Plant Physiol. 2017;174:2487-2500 pubmed publisher
    ..FACTOR3 (PIF3) and PIF1 transcription factors directly bind to the regulatory regions of ELONGATED HYPOCOTYL5 (HY5) and a B-box gene BBX23 and activate their expression in Arabidopsis (Arabidopsis thaliana)...
  60. Brown B, Jenkins G. UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH. Plant Physiol. 2008;146:576-88 pubmed
    ..Genes encoding the ELONGATED HYPOCOTYL5 (HY5) and HY5 HOMOLOG (HYH) transcription factors are induced at low UV-B fluence rates (0.1 micromol m(-2) s(-1))...
  61. Huang L, Zhang H, Zhang H, Deng X, Wei N. HY5 regulates nitrite reductase 1 (NIR1) and ammonium transporter1;2 (AMT1;2) in Arabidopsis seedlings. Plant Sci. 2015;238:330-9 pubmed publisher
    b>HY5 (Long Hypocotyles 5) is a key transcription factor in Arabidopsis thaliana that has a pivotal role in seedling development...
  62. Gangappa S, Holm M, Botto J. Molecular interactions of BBX24 and BBX25 with HYH, HY5 HOMOLOG, to modulate Arabidopsis seedling development. Plant Signal Behav. 2013;8: pubmed publisher
    ..recently, we have shown that BBX24 and BBX25 negatively regulate the expression of BBX22, reducing the function of HY5, by physically interacting with its bZIP domain...
  63. Jiang L, Wang Y, Li Q, Björn L, He J, Li S. Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity. Cell Res. 2012;22:1046-57 pubmed publisher
    ..which include UVR8 (a UV-B-specific photoreceptor), COP1 (a WD40-repeat-containing RING finger protein), HY5 (a basic zipper transcription factor), and RUP1/2 (two UVR8-interacting proteins)...
  64. Wei C, Chien C, Ai L, Zhao J, Zhang Z, Li K, et al. The Arabidopsis B-box protein BZS1/BBX20 interacts with HY5 and mediates strigolactone regulation of photomorphogenesis. J Genet Genomics. 2016;43:555-563 pubmed publisher
    ..proteomic workflow, we identified several BZS1-associated proteins, including light-signaling components COP1 and HY5. Direct interactions of BZS1 with COP1 and HY5 were verified by yeast two-hybrid and co-immunoprecipitation assays...
  65. Gangappa S, Kumar S. DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms. Cell Rep. 2017;18:344-351 pubmed publisher
    ..have been proposed to control thermosensory growth by transcriptional regulation of PIF4, through ELONGATED HYPOCOTYL 5 (HY5). Here, we show that DET1/COP1 and HY5 regulate thermosensory elongation through distinct mechanisms...
  66. Ulm R, Baumann A, Oravecz A, Mate Z, Adam E, Oakeley E, et al. Genome-wide analysis of gene expression reveals function of the bZIP transcription factor HY5 in the UV-B response of Arabidopsis. Proc Natl Acad Sci U S A. 2004;101:1397-402 pubmed
    ..Finally, we demonstrate that the bZIP transcription factor HY5 is required for UV-B-mediated regulation of a subset of genes.
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    ..Among its substrates is the basic domain/leucine zipper (bZIP) transcription factor ELONGATED HYPOCOTYL5 (HY5), one of the key regulators of photomorphogenesis under all light qualities, including UV-B responses required for ..
  68. Ram H, Priya P, Jain M, Chattopadhyay S. Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH. Mol Plant. 2014;7:448-51 pubmed publisher
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    ..b>HY5 directly binds to the MYBD promoter, which indicates that MYBD acts on HY5-downstream in light- or cytokinin-..
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    Among signaling components downstream of phytochrome A (phyA), HY5, HFR1 and LAF1 are transcription factors that regulate expression of phyA-responsive genes...
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    ..Our data further indicate that PFT1 regulates the floral transition downstream of phyA. The PFT1 missense mutation seems to create a constitutively active transcription factor by mimicking an early step in light signaling. ..
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    ..By using forward and reverse genetic approaches we found that ELONGATED HYPOCOTYL 5, LATE ELONGATED HYPOCOTYL, PHYTOCHROME KINASE SUBSTRATE 4 and auxin signalling are key players in this ..
  73. Abbas N, Chattopadhyay S. CAM7 and HY5 genetically interact to regulate root growth and abscisic acid responses. Plant Signal Behav. 2014;9:e29763 pubmed publisher
    ..b>HY5, a bZIP transcription factor, promotes photomorphogenesis at multiple wavelengths of light including far red, red, ..
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    ..BBX22, whose induction is both light regulated and HY5 dependent, is a positive regulator of deetiolation in Arabidopsis...