HSP81-2

Summary

Gene Symbol: HSP81-2
Description: heat shock protein 81-2
Alias: AtHsp90.2, EARLY-RESPONSIVE TO DEHYDRATION 8, ERD8, HEAT SHOCK PROTEIN 90.2, HEAT SHOCK PROTEIN 81-2, HEAT SHOCK PROTEIN 90.2, HSP81.2, HSP90.2, MDA7.7, MDA7_7, heat shock protein 81-2, heat shock protein 81.2, heat shock protein 81-2
Species: thale cress
Products:     HSP81-2

Top Publications

  1. Hubert D, Tornero P, Belkhadir Y, Krishna P, Takahashi A, Shirasu K, et al. Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 disease resistance protein. EMBO J. 2003;22:5679-89 pubmed
    ..Dynamic interactions among these proteins can regulate RPM1 stability and function, perhaps similarly to the formation and regulation of animal steroid receptor complexes. ..
  2. Song H, Zhao R, Fan P, Wang X, Chen X, Li Y. Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses. Planta. 2009;229:955-64 pubmed publisher
  3. Huang S, Monaghan J, Zhong X, Lin L, Sun T, Dong O, et al. HSP90s are required for NLR immune receptor accumulation in Arabidopsis. Plant J. 2014;79:427-39 pubmed publisher
    ..HSP90s may assist SGT1 in the formation of SCF E3 ubiquitin ligase complexes that target immune receptors for degradation. Such regulation is critical for maintaining appropriate levels of immune receptor proteins to avoid autoimmunity. ..
  4. Hubert D, He Y, McNulty B, Tornero P, Dangl J. Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation. Proc Natl Acad Sci U S A. 2009;106:9556-63 pubmed publisher
    ..Thus, in rar1, lid cycling is locked into a conformation favoring NB-LRR client degradation, likely via SGT1 and the proteasome. ..
  5. Earley K, Poethig R. Binding of the cyclophilin 40 ortholog SQUINT to Hsp90 protein is required for SQUINT function in Arabidopsis. J Biol Chem. 2011;286:38184-9 pubmed publisher
    ..Our results indicate that the interaction between CyP40 and Hsp90 is conserved in plants and that this interaction is essential for the function of CyP40. ..
  6. Popescu S, Popescu G, Bachan S, Zhang Z, Seay M, Gerstein M, et al. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Proc Natl Acad Sci U S A. 2007;104:4730-5 pubmed
    ..Our results suggest that calcium functions through distinct CaM/CML proteins to regulate a wide range of targets and cellular activities. ..
  7. Kadota Y, Amigues B, Ducassou L, Madaoui H, Ochsenbein F, Guerois R, et al. Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants. EMBO Rep. 2008;9:1209-15 pubmed publisher
  8. Yamada K, Nishimura M. Cytosolic heat shock protein 90 regulates heat shock transcription factor in Arabidopsis thaliana. Plant Signal Behav. 2008;3:660-2 pubmed
    ..Thus, it appears that in the absence of heat shock, cytosolic HSP90 negatively regulates HsfA1. Upon heat shock, cytosolic HSP90 is transiently inactivated, and this may lead to the activation of HsfA1. ..
  9. Clement M, Leonhardt N, Droillard M, Reiter I, Montillet J, Genty B, et al. The cytosolic/nuclear HSC70 and HSP90 molecular chaperones are important for stomatal closure and modulate abscisic acid-dependent physiological responses in Arabidopsis. Plant Physiol. 2011;156:1481-92 pubmed publisher
    ..This study demonstrates that the HSC70/HSP90 machinery is important for stomatal closure and serves essential functions in plants to integrate signals from their biotic and abiotic environments. ..

More Information

Publications18

  1. Schweiger R, Müller N, Schmitt M, Soll J, Schwenkert S. AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis. J Cell Sci. 2012;125:5196-207 pubmed publisher
  2. Lim C, Yang K, Hong J, Choi J, Yun D, Hong J, et al. Gene expression profiles during heat acclimation in Arabidopsis thaliana suspension-culture cells. J Plant Res. 2006;119:373-83 pubmed
    ..Moreover, the transcriptional induction of DREB2 (dehydration responsive element-binding factor 2) subfamily genes and COR47/rd17 under heat stress suggested cross-talk between the signaling pathways for heat and dehydration responses. ..
  3. Kriechbaumer V, Tsargorodskaya A, Mustafa M, Vinogradova T, Lacey J, Smith D, et al. Study of receptor-chaperone interactions using the optical technique of spectroscopic ellipsometry. Biophys J. 2011;101:504-11 pubmed publisher
  4. Yamada K, Fukao Y, Hayashi M, Fukazawa M, Suzuki I, Nishimura M. Cytosolic HSP90 regulates the heat shock response that is responsible for heat acclimation in Arabidopsis thaliana. J Biol Chem. 2007;282:37794-804 pubmed
    ..Upon heat shock, cytosolic HSP90 is transiently inactivated, which may lead to HSF activation. ..
  5. Schweiger R, Soll J, Jung K, Heermann R, Schwenkert S. Quantification of interaction strengths between chaperones and tetratricopeptide repeat domain-containing membrane proteins. J Biol Chem. 2013;288:30614-25 pubmed publisher
    ..The combinatory approach of several methods provided a powerful toolkit to determine binding affinities of similar interaction partners in a highly quantitative manner...
  6. Prasad B, Goel S, Krishna P. In silico identification of carboxylate clamp type tetratricopeptide repeat proteins in Arabidopsis and rice as putative co-chaperones of Hsp90/Hsp70. PLoS ONE. 2010;5:e12761 pubmed publisher
  7. Shigeta T, Zaizen Y, Asami T, Yoshida S, Nakamura Y, Okamoto S, et al. Molecular evidence of the involvement of heat shock protein 90 in brassinosteroid signaling in Arabidopsis T87 cultured cells. Plant Cell Rep. 2014;33:499-510 pubmed publisher
    ..Together, our results provide important clues to elucidate HSP90s' functions in the BR signaling pathway in Arabidopsis. ..
  8. Kim T, Kim W, Fujiwara S, Kim J, Cha J, Park J, et al. HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE. Proc Natl Acad Sci U S A. 2011;108:16843-8 pubmed publisher
    ..Unlike metazoan systems, HSP90 functions here within the core oscillator. Additionally, F-box proteins as clients may place HSP90 in a unique and more central role in proteostasis. ..
  9. Prasinos C, Krampis K, Samakovli D, Hatzopoulos P. Tight regulation of expression of two Arabidopsis cytosolic Hsp90 genes during embryo development. J Exp Bot. 2005;56:633-44 pubmed
    ..The developmental and restricted pattern of expression of the AtHsp90-1 and -3 gene promoters in unstressed transgenic plants suggest prominent and distinctive roles of these two genes during different developmental processes. ..