Gene Symbol: HSP101
Description: heat shock protein 101
Alias: ATHSP101, F1O17.2, F1O17_2, HEAT SHOCK PROTEIN ATHSP101, HOT1, heat shock protein 101, heat shock protein 101
Species: thale cress
Products:     HSP101

Top Publications

  1. Tonsor S, Scott C, Boumaza I, Liss T, Brodsky J, Vierling E. Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions. Mol Ecol. 2008;17:1614-26 pubmed publisher
    ..In controlled environment experiments, we examined the effects of variation in the Arabidopsis cytosolic AtHsp101 (hereafter Hsp101)...
  2. Hong S, Vierling E. Mutants of Arabidopsis thaliana defective in the acquisition of tolerance to high temperature stress. Proc Natl Acad Sci U S A. 2000;97:4392-7 pubmed
    ..hot1 was found to have a mutation in the heat shock protein 101 (Hsp101) gene, converting a conserved Glu residue in the second ATP-binding domain to a Lys residue, a ..
  3. Lee U, Wie C, Escobar M, Williams B, Hong S, Vierling E. Genetic analysis reveals domain interactions of Arabidopsis Hsp100/ClpB and cooperation with the small heat shock protein chaperone system. Plant Cell. 2005;17:559-71 pubmed
    We have defined amino acids important for function of the Arabidopsis thaliana Hsp100/ClpB chaperone (AtHsp101) in acquired thermotolerance by isolating recessive, loss-of-function mutations and a novel semidominant, gain-of-function ..
  4. Larkindale J, Hall J, Knight M, Vierling E. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 2005;138:882-97 pubmed
    ..oxidative damage and alterations in the heat shock response, thiobarbituric acid reactive substances, heat shock protein 101, and small heat shock protein levels were determined. Fifteen mutants showed significant phenotypes...
  5. Schirmer E, Lindquist S, Vierling E. An Arabidopsis heat shock protein complements a thermotolerance defect in yeast. Plant Cell. 1994;6:1899-909 pubmed
    ..We isolated a cDNA corresponding to one of these proteins from Arabidopsis. The protein, AtHSP101, is 43% identical to yeast Hsp104...
  6. Wu T, Juan Y, Hsu Y, Wu S, Liao H, Fung R, et al. Interplay between heat shock proteins HSP101 and HSA32 prolongs heat acclimation memory posttranscriptionally in Arabidopsis. Plant Physiol. 2013;161:2075-84 pubmed publisher
    ..Two recessive missense alleles, dlt1-1 and dlt1-2, encode the molecular chaperone heat shock protein101 (HSP101)...
  7. Xu X, Song H, Zhou Z, Shi N, Ying Q, Wang H. Functional characterization of AtHsp90.3 in Saccharomyces cerevisiae and Arabidopsis thaliana under heat stress. Biotechnol Lett. 2010;32:979-87 pubmed publisher
    ..Transcriptional expression of heat stress transcription factors, AtHsfA1d, AtHsfA7a and AtHsfB1, and two Hsps, AtHsp101 and AtHsp17, was delayed by constitutive overexpression of cytosolic AtHsp90.3 under heat stress...
  8. Nishizawa A, Yabuta Y, Yoshida E, Maruta T, Yoshimura K, Shigeoka S. Arabidopsis heat shock transcription factor A2 as a key regulator in response to several types of environmental stress. Plant J. 2006;48:535-47 pubmed
    ..Our present results indicate that HsfA2 is a key regulator in the induction of the defence system under several types of environmental stress. ..
  9. McLoughlin F, Basha E, Fowler M, Kim M, Bordowitz J, Katiyar Agarwal S, et al. Class I and II Small Heat Shock Proteins Together with HSP101 Protect Protein Translation Factors during Heat Stress. Plant Physiol. 2016;172:1221-1236 pubmed
    ..RNAi lines, showed reduced recovery to the soluble cell fraction after heat stress, which was also dependent on HSP101. Furthermore, after heat stress, CI sHSPs showed increased retention in the insoluble fraction in the CII RNAi ..

More Information


  1. Merret R, Carpentier M, Favory J, Picart C, Descombin J, Bousquet Antonelli C, et al. Heat Shock Protein HSP101 Affects the Release of Ribosomal Protein mRNAs for Recovery after Heat Shock. Plant Physiol. 2017;174:1216-1225 pubmed publisher
    ..In this work, we report that Arabidopsis HEAT SHOCK PROTEIN101 (HSP101) knockout mutant (hsp101) presented a defect in translation recovery and SG dissociation after HS Using ..
  2. Zimmerli L, Hou B, Tsai C, Jakab G, Mauch Mani B, Somerville S. The xenobiotic beta-aminobutyric acid enhances Arabidopsis thermotolerance. Plant J. 2008;53:144-56 pubmed
    ..This thermotolerance was dependent on heat shock protein 101, a critical component of the normal heat-shock response...