HSFA2

Summary

Gene Symbol: HSFA2
Description: heat shock transcription factor A2
Alias: ATHSFA2, T19L18.4, T19L18_4, heat shock transcription factor A2, heat shock transcription factor A2
Species: thale cress

Top Publications

  1. Port M, Tripp J, Zielinski D, Weber C, Heerklotz D, Winkelhaus S, et al. Role of Hsp17.4-CII as coregulator and cytoplasmic retention factor of tomato heat stress transcription factor HsfA2. Plant Physiol. 2004;135:1457-70 pubmed
    b>HsfA2 is a heat stress (hs)-induced Hsf in peruvian tomato (Lycopersicon peruvianum) and the cultivated form Lycopersicon esculentum...
  2. Nishizawa A, Yabuta Y, Yoshida E, Maruta T, Yoshimura K, Shigeoka S. Arabidopsis heat shock transcription factor A2 as a key regulator in response to several types of environmental stress. Plant J. 2006;48:535-47 pubmed
    ..high-light and heat-shock (HL + HS) stress-inducible genes, including a putative heat-shock transcription factor (HsfA2), by suppression-subtractive hybridization from Arabidopsis...
  3. Cohen Peer R, Schuster S, Meiri D, Breiman A, Avni A. Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholerance. Plant Mol Biol. 2010;74:33-45 pubmed publisher
    ..In this work we show SUMOylation of the heat shock transcription factor, AtHsfA2, in connection with the plant's response to heat stress and acquired thermotolerance...
  4. Nishizawa Yokoi A, Nosaka R, Hayashi H, Tainaka H, Maruta T, Tamoi M, et al. HsfA1d and HsfA1e involved in the transcriptional regulation of HsfA2 function as key regulators for the Hsf signaling network in response to environmental stress. Plant Cell Physiol. 2011;52:933-45 pubmed publisher
    b>Heat shock transcription factor A2 (HsfA2) acts as a key component of the Hsf signaling network involved in cellular responses to various types of environmental stress...
  5. Nishizawa Yokoi A, Yoshida E, Yabuta Y, Shigeoka S. Analysis of the regulation of target genes by an Arabidopsis heat shock transcription factor, HsfA2. Biosci Biotechnol Biochem. 2009;73:890-5 pubmed
    We have isolated a high-light and heat-shock inducible gene, Arabidopsis heat shock transcription factor (HsfA2), which induces expression of various types of target gene such as heat shock protein 18.2-CI (Hsp18...
  6. Charng Y, Liu H, Liu N, Chi W, Wang C, Chang S, et al. A heat-inducible transcription factor, HsfA2, is required for extension of acquired thermotolerance in Arabidopsis. Plant Physiol. 2007;143:251-62 pubmed
    ..Among the tested mutants corresponding to 48 heat-induced genes, only the heat shock transcription factor HsfA2 knockout mutant showed an obvious phenotype...
  7. Meiri D, Breiman A. Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs. Plant J. 2009;59:387-99 pubmed publisher
    ..1 complex, which is dependent upon the presence of the transcription factor HsfA2, which interacts with HSP90.1 but not with ROF1...
  8. Nishizawa Yokoi A, Tainaka H, Yoshida E, Tamoi M, Yabuta Y, Shigeoka S. The 26S proteasome function and Hsp90 activity involved in the regulation of HsfA2 expression in response to oxidative stress. Plant Cell Physiol. 2010;51:486-96 pubmed publisher
    b>Heat shock transcription factor A2 (HsfA2) is induced under environmental stress and regulates transcription of various defense-related genes...
  9. Hsu S, Lai H, Jinn T. Cytosol-localized heat shock factor-binding protein, AtHSBP, functions as a negative regulator of heat shock response by translocation to the nucleus and is required for seed development in Arabidopsis. Plant Physiol. 2010;153:773-84 pubmed publisher
    ..two-hybrid assay results confirmed that AtHSBP interacts with itself and with the HSFs, AtHSFA1a, AtHSFA1b, and AtHSFA2. AtHSBP also negatively affected AtHSFA1b DNA-binding capacity in vitro...

More Information

Publications19

  1. Zhang L, Li Y, Xing D, Gao C. Characterization of mitochondrial dynamics and subcellular localization of ROS reveal that HsfA2 alleviates oxidative damage caused by heat stress in Arabidopsis. J Exp Bot. 2009;60:2073-91 pubmed publisher
    b>Heat shock transcription factor A2 (HsfA2) participates in multiple stress responses...
  2. Yu H, Yang X, Chen S, Wang Y, Li J, Shen Q, et al. Downregulation of chloroplast RPS1 negatively modulates nuclear heat-responsive expression of HsfA2 and its target genes in Arabidopsis. PLoS Genet. 2012;8:e1002669 pubmed publisher
    ..Although heat stress transcription factor HsfA2 and its downstream target genes are well studied, the regulatory mechanisms by which HsfA2 is activated in ..
  3. Li M, Berendzen K, Schöffl F. Promoter specificity and interactions between early and late Arabidopsis heat shock factors. Plant Mol Biol. 2010;73:559-67 pubmed publisher
    ..A second set of heat shock promoters (HsfA2, Hsp17.6CII, Hsp17.6C-CI) was activated to much lower levels...
  4. Li C, Chen Q, Gao X, Qi B, Chen N, Xu S, et al. AtHsfA2 modulates expression of stress responsive genes and enhances tolerance to heat and oxidative stress in Arabidopsis. Sci China C Life Sci. 2005;48:540-50 pubmed
    ..In this paper, we present evidence that AtHsfA2 modulated expression of stress responsive genes and enhanced tolerance to heat and oxidative stress in ..
  5. Liu J, Sun N, Liu M, Liu J, Du B, Wang X, et al. An autoregulatory loop controlling Arabidopsis HsfA2 expression: role of heat shock-induced alternative splicing. Plant Physiol. 2013;162:512-21 pubmed publisher
    Heat shock transcription factorA2 (HsfA2) is a key regulator in response to heat stress in Arabidopsis (Arabidopsis thaliana), and its heat shock (HS)-induced transcription regulation has been extensively studied...
  6. Sugio A, Dreos R, Aparicio F, Maule A. The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis. Plant Cell. 2009;21:642-54 pubmed publisher
    ..associated with the heat shock promoter element and the involvement of specific heat shock factors (HSFs), notably HSFA2, which appears to be regulated by alternative splicing and non-sense-mediated decay...
  7. Masuda S, Tokaji Y, Kobayashi Y, Ohta H. Mechanisms of induction of the stress-responsive transcription factors HsfA2 and DREB2A by 12-oxo-phytodienoic acid in Arabidopsis thaliana. Biosci Biotechnol Biochem. 2014;78:647-50 pubmed publisher
    ..Here, we measured transcriptional responses of the OPDA-responsive genes HsfA2 and DREB2A to the protein synthesis inhibitor cycloheximide and to the HSP90 inhibitor geldanamycin...
  8. Tunc Ozdemir M, Tang C, Ishka M, Brown E, Groves N, Myers C, et al. A cyclic nucleotide-gated channel (CNGC16) in pollen is critical for stress tolerance in pollen reproductive development. Plant Physiol. 2013;161:1010-20 pubmed publisher
    ..attenuated expression of several heat-stress response genes, including two heat shock transcription factor genes, HsfA2 and HsfB1...
  9. Banti V, Mafessoni F, Loreti E, Alpi A, Perata P. The heat-inducible transcription factor HsfA2 enhances anoxia tolerance in Arabidopsis. Plant Physiol. 2010;152:1471-83 pubmed publisher
    ..Among the transcription factors induced by both heat and anoxia, the heat shock factor A2 (HsfA2), known to be involved in Arabidopsis acclimation to heat and to other abiotic stresses, was strongly induced by ..
  10. Llamas E, Pulido P, Rodríguez Concepción M. Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis. PLoS Genet. 2017;13:e1007022 pubmed publisher
    ..unfolded protein response (cpUPR) mechanism appears to be mediated by the heat shock transcription factor HsfA2. Expression of HsfA2 and cpUPR-related target genes is independent of GUN1, a central integrator of retrograde ..