Gene Symbol: HSC70-1
Description: heat shock cognate protein 70-1
Alias: ARABIDOPSIS THALIANA HEAT SHOCK COGNATE PROTEIN 70-1, AT-HSC70-1, AtHsp70-1, HEAT SHOCK COGNATE PROTEIN 70, HEAT SHOCK PROTEIN 70-1, HSC70, HSP70-1, T22P11.90, T22P11_90, heat shock cognate protein 70-1, heat shock cognate protein 70-1
Species: thale cress

Top Publications

  1. Noël L, Cagna G, Stuttmann J, Wirthmüller L, Betsuyaku S, Witte C, et al. Interaction between SGT1 and cytosolic/nuclear HSC70 chaperones regulates Arabidopsis immune responses. Plant Cell. 2007;19:4061-76 pubmed
    ..from Arabidopsis thaliana leaf extracts and identified by mass spectrometry cytosolic heat shock cognate 70 (HSC70) chaperones as the major stable SGT1 interactors...
  2. Kriechbaumer V, Tsargorodskaya A, Mustafa M, Vinogradova T, Lacey J, Smith D, et al. Study of receptor-chaperone interactions using the optical technique of spectroscopic ellipsometry. Biophys J. 2011;101:504-11 pubmed publisher
  3. Jungkunz I, Link K, Vogel F, Voll L, Sonnewald S, Sonnewald U. AtHsp70-15-deficient Arabidopsis plants are characterized by reduced growth, a constitutive cytosolic protein response and enhanced resistance to TuMV. Plant J. 2011;66:983-95 pubmed publisher
    ..Based on these results, AtHsp70-15 is likely to be a key factor in proper folding of cytosolic proteins, and may function as nucleotide exchange factor as proposed for yeast. ..
  4. Kim B, Schöffl F. Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins. J Exp Bot. 2002;53:371-5 pubmed
    ..Here the interaction between HSF and HSP70 is reported using electrophoretic mobility shift and yeast two-hybrid assays. Subdomain mapping indicates an interaction of the activation domain and DNA-binding domain of HSF1 with HSP70. ..
  5. Koizumi S, Ohama N, Mizoi J, Shinozaki K, Yamaguchi Shinozaki K. Functional analysis of the Hikeshi-like protein and its interaction with HSP70 in Arabidopsis. Biochem Biophys Res Commun. 2014;450:396-400 pubmed publisher
    ..Our results suggest that HKL plays a positive role in the thermotolerance of Arabidopsis plants and cooperatively interacts with HSP70. ..
  6. Schweiger R, Soll J, Jung K, Heermann R, Schwenkert S. Quantification of interaction strengths between chaperones and tetratricopeptide repeat domain-containing membrane proteins. J Biol Chem. 2013;288:30614-25 pubmed publisher
    ..The combinatory approach of several methods provided a powerful toolkit to determine binding affinities of similar interaction partners in a highly quantitative manner...
  7. Kluth J, Schmidt A, Marz M, Krupinska K, Lorbiecke R. Arabidopsis Zinc Ribbon 3 is the ortholog of yeast mitochondrial HSP70 escort protein HEP1 and belongs to an ancient protein family in mitochondria and plastids. FEBS Lett. 2012;586:3071-6 pubmed publisher
    ..Accordingly, ZR3 was found to physically interact with mitochondrial Hsp70 from Arabidopsis. Our findings support the idea that mitochondrial and plastidic ZR proteins from higher plants are orthologs of HEP proteins. ..
  8. Clement M, Leonhardt N, Droillard M, Reiter I, Montillet J, Genty B, et al. The cytosolic/nuclear HSC70 and HSP90 molecular chaperones are important for stomatal closure and modulate abscisic acid-dependent physiological responses in Arabidopsis. Plant Physiol. 2011;156:1481-92 pubmed publisher
    Cytosolic/nuclear molecular chaperones of the heat shock protein families HSP90 and HSC70 are conserved and essential proteins in eukaryotes...
  9. Sung D, Vierling E, Guy C. Comprehensive expression profile analysis of the Arabidopsis Hsp70 gene family. Plant Physiol. 2001;126:789-800 pubmed

More Information


  1. Isono E, Katsiarimpa A, Müller I, Anzenberger F, Stierhof Y, Geldner N, et al. The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana. Plant Cell. 2010;22:1826-37 pubmed publisher
    ..Furthermore, AMSH3 is required for efficient endocytosis of the styryl dye FM4-64 and the auxin efflux facilitator PIN2. We thus present evidence for a role of deubiquitination in intracellular trafficking and vacuole biogenesis. ..
  2. Kang C, Jung W, Kang Y, Kim J, Kim D, Jeong J, et al. AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants. Cell Death Differ. 2006;13:84-95 pubmed
    ..Collectively, these results suggest that AtBAG6 is a stress-upregulated CaM-binding protein involved in plant PCD. ..
  3. Brkljacic J, Zhao Q, Meier I. WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. Plant Physiol. 2009;151:142-54 pubmed publisher
    ..Here, we show that WIT1 also binds WPP1 and WPP2 in planta, we identify the chaperone heat shock cognate protein 70-1 (HSC70-1) as in vivo interaction partner of WPP1 and WPP2, and we show that HSC70-1 interacts in ..
  4. Pusch S, Harashima H, Schnittger A. Identification of kinase substrates by bimolecular complementation assays. Plant J. 2012;70:348-56 pubmed publisher
    ..As a proof of functionality, we present the identification and in vivo confirmation of substrates of the major cell-cycle kinase in Arabidopsis, revealing a direct link between cell proliferation and the control of the redox state. ..
  5. Aparicio F, Thomas C, Lederer C, Niu Y, Wang D, Maule A. Virus induction of heat shock protein 70 reflects a general response to protein accumulation in the plant cytosol. Plant Physiol. 2005;138:529-36 pubmed
    ..This phenomenon is reminiscent of the unfolded protein response observed when the induced accumulation of proteins in the endoplasmic reticulum also induces a specific suite of chaperones. ..
  6. Gou M, Zhang Z, Zhang N, Huang Q, Monaghan J, Yang H, et al. Opposing Effects on Two Phases of Defense Responses from Concerted Actions of HEAT SHOCK COGNATE70 and BONZAI1 in Arabidopsis. Plant Physiol. 2015;169:2304-23 pubmed publisher
    ..The HEAT SHOCK COGNATE70 (HSC70), while previously known as a negative regulator of stomatal closure, is a positive regulator of immune responses ..
  7. Schweiger R, Müller N, Schmitt M, Soll J, Schwenkert S. AtTPR7 is a chaperone-docking protein of the Sec translocon in Arabidopsis. J Cell Sci. 2012;125:5196-207 pubmed publisher
  8. Trösch R, Töpel M, Flores Pérez Ã, Jarvis P. Genetic and Physical Interaction Studies Reveal Functional Similarities between ALBINO3 and ALBINO4 in Arabidopsis. Plant Physiol. 2015;169:1292-306 pubmed publisher
    ..g. cytochrome f and the Rieske protein). Although ALB4 has clearly diverged from ALB3 in relation to the partner-recruiting C-terminal domain, our analysis suggests that one putative cpSRP-binding motif has not been entirely lost. ..
  9. Cazalé A, Clement M, Chiarenza S, Roncato M, Pochon N, Creff A, et al. Altered expression of cytosolic/nuclear HSC70-1 molecular chaperone affects development and abiotic stress tolerance in Arabidopsis thaliana. J Exp Bot. 2009;60:2653-64 pubmed publisher
    Molecular chaperones of the heat shock cognate 70 kDa (HSC70) family are highly conserved in all living organisms and assist nascent protein folding in normal physiological conditions as well as in biotic and abiotic stress conditions...