HRT

Summary

Gene Symbol: HRT
Description: Disease resistance protein (CC-NBS-LRR class) family
Alias: DISEASE RESISTANCE PROTEIN RPP8, HRT, HYPERSENSITIVE RESPONSE TO TCV, MWF20.19, MWF20_19, RCY1, RECOGNITION OF PERONOSPORA PARASITICA 8, RESISTANT TO CMV(Y) 1, Disease resistance protein (CC-NBS-LRR class) family
Species: thale cress

Top Publications

  1. Chandra Shekara A, Gupte M, Navarre D, Raina S, Raina R, Klessig D, et al. Light-dependent hypersensitive response and resistance signaling against Turnip Crinkle Virus in Arabidopsis. Plant J. 2006;45:320-34 pubmed
    Resistance to Turnip Crinkle Virus (TCV) in Arabidopsis ecotype Dijon (Di)-17 is conferred by the resistance gene HRT and a recessive locus rrt...
  2. Jeong R, Chandra Shekara A, Barman S, Navarre D, Klessig D, Kachroo A, et al. Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase. Proc Natl Acad Sci U S A. 2010;107:13538-43 pubmed publisher
    ..photoreceptors, cryptochrome (CRY) 2 and phototropin (PHOT) 2, are required for the stability of the R protein HRT, and thereby resistance to Turnip Crinkle virus (TCV)...
  3. Chandra Shekara A, Navarre D, Kachroo A, Kang H, Klessig D, Kachroo P. Signaling requirements and role of salicylic acid in HRT- and rrt-mediated resistance to turnip crinkle virus in Arabidopsis. Plant J. 2004;40:647-59 pubmed
    ..Previous genetic analyses revealed that the HR to TCV is conferred by HRT, which encodes a coiled-coil (CC), nucleotide-binding site (NBS) and leucine-rich repeat (LRR) class resistance (R) ..
  4. Kang H, Oh C, Sato M, Katagiri F, Glazebrook J, Takahashi H, et al. Endosome-associated CRT1 functions early in resistance gene-mediated defense signaling in Arabidopsis and tobacco. Plant Cell. 2010;22:918-36 pubmed publisher
    ..Confocal microscopy and subcellular fractionation revealed that CRT1 localizes to endosome-like vesicles, suggesting a key process in resistance protein activation/signaling occurs in this subcellular compartment. ..
  5. Zhu S, Jeong R, Venugopal S, Lapchyk L, Navarre D, Kachroo A, et al. SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus. PLoS Pathog. 2011;7:e1002318 pubmed publisher
    ..However, only EDS1 is required for HRT-mediated HR to TCV, while only PAD4 is required for SA-dependent induction of HRT...
  6. Meyers B, Dickerman A, Michelmore R, Sivaramakrishnan S, Sobral B, Young N. Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily. Plant J. 1999;20:317-32 pubmed
    ..Sequence inferences suggest that these genes encode a novel class of nucleotide-binding proteins. ..
  7. Mohr T, Mammarella N, Hoff T, Woffenden B, Jelesko J, McDowell J. The Arabidopsis downy mildew resistance gene RPP8 is induced by pathogens and salicylic acid and is regulated by W box cis elements. Mol Plant Microbe Interact. 2010;23:1303-15 pubmed publisher
    ..These results indicate that WRKY transcription factors can regulate expression of surveillance genes at the top of the defense-signaling cascade. ..
  8. Zhu S, Lim G, Yu K, Jeong R, Kachroo A, Kachroo P. RNA silencing components mediate resistance signaling against turnip crinkle virus. Plant Signal Behav. 2014;9:e28435 pubmed
    ..In Arabidopsis, the R protein HRT, which confers resistance to turnip crinkle virus (TCV), is activated upon recognition of the TCV coat-protein (CP),..
  9. Wang J, Shine M, Gao Q, Navarre D, Jiang W, Liu C, et al. Enhanced Disease Susceptibility1 Mediates Pathogen Resistance and Virulence Function of a Bacterial Effector in Soybean. Plant Physiol. 2014;165:1269-1284 pubmed
    ..coat protein-mediated activation of the Arabidopsis R protein Hypersensitive reaction to Turnip crinkle virus (HRT), even though both interacted with HRT...

More Information

Publications12

  1. Yoshii M, Yoshioka N, Ishikawa M, Naito S. Isolation of an Arabidopsis thaliana mutant in which accumulation of cucumber mosaic virus coat protein is delayed. Plant J. 1998;13:211-9 pubmed
  2. McDowell J, Dhandaydham M, Long T, Aarts M, Goff S, Holub E, et al. Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis. Plant Cell. 1998;10:1861-74 pubmed
    ..These observations indicate that NBS-LRR molecular evolution is driven by the same mechanisms that promote rapid sequence diversification among other genes involved in non-self-recognition. ..
  3. Kuang H, Caldwell K, Meyers B, Michelmore R. Frequent sequence exchanges between homologs of RPP8 in Arabidopsis are not necessarily associated with genomic proximity. Plant J. 2008;54:69-80 pubmed publisher
    ..Arabidopsis thaliana is located at a complex locus that also harbors the sequence-related resistance genes HRT and RCY1 in different ecotypes. We sequenced 98 homologs of RPP8 from A...