Gene Symbol: HDA6
Description: histone deacetylase 6
Alias: ATHDA6, AXE1, HISTONE DEACETYLASE 6, MDC12.7, MDC12_7, RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1, RPD3B, RTS1, SIL1, histone deacetylase 6, histone deacetylase 6
Species: thale cress

Top Publications

  1. Murfett J, Wang X, Hagen G, Guilfoyle T. Identification of Arabidopsis histone deacetylase HDA6 mutants that affect transgene expression. Plant Cell. 2001;13:1047-61 pubmed
    ..The specific effect of AtHDA6 mutations on the auxin-responsive transgenes implicates this RPD3-like histone deacetylase as playing a role in ..
  2. To T, Kim J, Matsui A, Kurihara Y, Morosawa T, Ishida J, et al. Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET1. PLoS Genet. 2011;7:e1002055 pubmed publisher
    ..Histone deacetylase HDA6 has been identified as a component of such machineries; however, its endogenous targets and the silencing ..
  3. Liu X, Yu C, Duan J, Luo M, Wang K, Tian G, et al. HDA6 directly interacts with DNA methyltransferase MET1 and maintains transposable element silencing in Arabidopsis. Plant Physiol. 2012;158:119-29 pubmed publisher
    The molecular mechanism of how the histone deacetylase HDA6 participates in maintaining transposable element (TE) silencing in Arabidopsis (Arabidopsis thaliana) is not yet defined...
  4. Wu K, Zhang L, Zhou C, Yu C, Chaikam V. HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis. J Exp Bot. 2008;59:225-34 pubmed publisher
    ..HDA6 is a RPD3-type histone deacetylase in Arabidopsis. The Arabidopsis HDA6 mutant, axe1-5, and HDA6 RNA-interfering (HDA6-RNAi) plants displayed higher levels of acetylated H3 compared with wild-type, ..
  5. Chen L, Luo M, Wang Y, Wu K. Involvement of Arabidopsis histone deacetylase HDA6 in ABA and salt stress response. J Exp Bot. 2010;61:3345-53 pubmed publisher
    ..HDA6 is an RPD3-type histone deacetylase in Arabidopsis. The Arabidopsis HDA6 mutant, axe1-5, and HDA6 RNA-interfering plants displayed a phenotype that was hypersensitive to ABA and salt stress...
  6. Earley K, Lawrence R, Pontes O, Reuther R, Enciso A, Silva M, et al. Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Genes Dev. 2006;20:1283-93 pubmed
    ..An RNA interference (RNAi) knockdown screen revealed that the predicted Arabidopsis histone deacetylase, HDA6, is required for rRNA gene silencing in nucleolar dominance...
  7. Furner I, Sheikh M, Collett C. Gene silencing and homology-dependent gene silencing in Arabidopsis: genetic modifiers and DNA methylation. Genetics. 1998;149:651-62 pubmed
    ..Two further monogenic, trans-acting, recessive mutations (sil1 and sil2) reduce gene silencing but not HDG silencing...
  8. Aufsatz W, Mette M, van der Winden J, Matzke M, Matzke A. HDA6, a putative histone deacetylase needed to enhance DNA methylation induced by double-stranded RNA. EMBO J. 2002;21:6832-41 pubmed
    ..One mutant, rts1 (RNA-mediated transcriptional silencing), displayed moderate recovery of NPTII gene expression and partial loss of ..
  9. Chen L, Wu K. Role of histone deacetylases HDA6 and HDA19 in ABA and abiotic stress response. Plant Signal Behav. 2010;5:1318-20 pubmed publisher
    Our recent study revealed the involvement of the Arabidopsis histone deacetylase HDA6 in modulating ABA and salt stress responses. In this report, we further investigated the role of HDA19 in ABA and salt stress responses...

More Information


  1. Tanaka M, Kikuchi A, Kamada H. The Arabidopsis histone deacetylases HDA6 and HDA19 contribute to the repression of embryonic properties after germination. Plant Physiol. 2008;146:149-61 pubmed
    ..Here, we show that treatment of an HDA6 repression line with the HDAC inhibitor trichostatin A resulted in growth arrest and elevated transcription of LEC1,..
  2. Earley K, Pontvianne F, Wierzbicki A, Blevins T, Tucker S, Costa Nunes P, et al. Mechanisms of HDA6-mediated rRNA gene silencing: suppression of intergenic Pol II transcription and differential effects on maintenance versus siRNA-directed cytosine methylation. Genes Dev. 2010;24:1119-32 pubmed publisher
    The Arabidopsis histone deacetylase HDA6 is required to silence transgenes, transposons, and ribosomal RNA (rRNA) genes subjected to nucleolar dominance in genetic hybrids...
  3. Yu C, Liu X, Luo M, Chen C, Lin X, Tian G, et al. HISTONE DEACETYLASE6 interacts with FLOWERING LOCUS D and regulates flowering in Arabidopsis. Plant Physiol. 2011;156:173-84 pubmed publisher
    ..HISTONE DEACETYLASE6 (HDA6) is a REDUCED POTASSIUM DEPENDENCY3-type histone deacetylase, and the Arabidopsis (Arabidopsis thaliana) hda6 ..
  4. Hao Y, Wang H, Qiao S, Leng L, Wang X. Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase. Proc Natl Acad Sci U S A. 2016;113:10418-23 pubmed publisher
    ..Here we report that the histone deacetylase HDA6 can interact with and deacetylate BIN2 to repress its kinase activity...
  5. To T, Nakaminami K, Kim J, Morosawa T, Ishida J, Tanaka M, et al. Arabidopsis HDA6 is required for freezing tolerance. Biochem Biophys Res Commun. 2011;406:414-9 pubmed publisher
    ..Here we show, for the first time, that the histone deacetylase gene HDA6 is required for cold acclimation and freezing tolerance in Arabidopsis...
  6. Devoto A, Nieto Rostro M, Xie D, Ellis C, Harmston R, Patrick E, et al. COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis. Plant J. 2002;32:457-66 pubmed
    ..COI1 is therefore expected to form a functional E3-type ubiquitin ligase in plants and to regulate expression of jasmonate responsive genes, possibly by targeted ubiquitination of a histone deacetylase. ..
  7. Parida A, Sharma A, Sharma A. AtMBD6, a methyl CpG binding domain protein, maintains gene silencing in Arabidopsis by interacting with RNA binding proteins. J Biosci. 2017;42:57-68 pubmed
    ..The fourth protein that physically interacts with AtMBD6 is a histone-modifying enzyme, histone deacetylase 6 (AtHDA6), which is a known component of the RNA-mediated gene silencing system...
  8. Yun J, Kim Y, Jung J, Seo P, Park C. The AT-hook motif-containing protein AHL22 regulates flowering initiation by modifying FLOWERING LOCUS T chromatin in Arabidopsis. J Biol Chem. 2012;287:15307-16 pubmed publisher
    ..We propose that AHL22 acts as a chromatin remodeling factor that modifies the architecture of FT chromatin by modulating both H3 acetylation and methylation. ..
  9. Tessadori F, van Zanten M, Pavlova P, Clifton R, Pontvianne F, Snoek L, et al. Phytochrome B and histone deacetylase 6 control light-induced chromatin compaction in Arabidopsis thaliana. PLoS Genet. 2009;5:e1000638 pubmed publisher
    ..Trait Locus (QTL) mapping and microscopic examination, pointed at PHYTOCHROME-B (PHYB) and HISTONE DEACETYLASE-6 (HDA6) as positive regulators of light-controlled chromatin compaction...
  10. Willmann M, Mehalick A, Packer R, Jenik P. MicroRNAs regulate the timing of embryo maturation in Arabidopsis. Plant Physiol. 2011;155:1871-84 pubmed publisher
    ..transcription factors ARABIDOPSIS 6B-INTERACTING PROTEIN1-LIKE1 (ASIL1) and ASIL2 and the histone deacetylase HDA6/SIL1 as components that act downstream of miRNAs to repress the maturation program early in embryogenesis...
  11. Li D, Chen W, Xu Z, Bai S. HISTONE DEACETYLASE6-Defective Mutants Show Increased Expression and Acetylation of ENHANCER OF TRIPTYCHON AND CAPRICE1 and GLABRA2 with Small But Significant Effects on Root Epidermis Cellular Pattern. Plant Physiol. 2015;168:1448-58 pubmed publisher
    ..Here, we report that HISTONE DEACETYLASE6 (HDA6) has significant effects on this cellular patterning...
  12. Gu X, Jiang D, Yang W, Jacob Y, Michaels S, He Y. Arabidopsis homologs of retinoblastoma-associated protein 46/48 associate with a histone deacetylase to act redundantly in chromatin silencing. PLoS Genet. 2011;7:e1002366 pubmed publisher
    ..Both FVE and MSI5 associate with HISTONE DEACETYLASE 6 (HDA6) to form complexes and directly interact with the target loci, leading to histone deacetylation and ..
  13. Luo M, Wang Y, Liu X, Yang S, Lu Q, Cui Y, et al. HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis. J Exp Bot. 2012;63:3297-306 pubmed publisher
    ..Moreover, it was demonstrated that HD2C interacted physically with a RPD3-type histone deacetylase, HDA6, and bound to histone H3...
  14. Hristova E, Fal K, Klemme L, Windels D, Bucher E. HISTONE DEACETYLASE6 Controls Gene Expression Patterning and DNA Methylation-Independent Euchromatic Silencing. Plant Physiol. 2015;168:1298-308 pubmed publisher
    ..The forward genetic screen led to the identification of a novel HISTONE DEACETYLASE6 (HDA6) mutant allele (epigenetic control1, hda6-8)...
  15. Jung J, Park J, Lee S, To T, Kim J, Seki M, et al. The cold signaling attenuator HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE1 activates FLOWERING LOCUS C transcription via chromatin remodeling under short-term cold stress in Arabidopsis. Plant Cell. 2013;25:4378-90 pubmed publisher
    ..we show that HOS1 induces FLC expression by antagonizing the actions of FVE and its interacting partner histone deacetylase 6 (HDA6) under short-term cold stress...
  16. Wang Y, Hu Q, Wu Z, Wang H, Han S, Jin Y, et al. HISTONE DEACETYLASE 6 represses pathogen defence responses in Arabidopsis thaliana. Plant Cell Environ. 2017;40:2972-2986 pubmed publisher
    ..However, how defence responses are repressed is not well understood. Histone deacetylase 6 (HDA6) is a negative regulator of gene expression, and its role in pathogen defence response in plants is ..
  17. Luo M, Tai R, Yu C, Yang S, Chen C, Lin W, et al. Regulation of flowering time by the histone deacetylase HDA5 in Arabidopsis. Plant J. 2015;82:925-36 pubmed publisher
    ..fluorescence complementation assays and co-immunoprecipitation assays showed that HDA5 interacts with FVE, FLD and HDA6, indicating that these proteins are present in a protein complex involved in the regulation of flowering time...
  18. Lee W, Cho M. Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana. Nucleic Acids Res. 2016;44:4610-24 pubmed publisher
    ..Here, we show direct interactions between the telomere-binding protein, AtTRB2 and histone deacetylases, HDT4 and HDA6, in vitro and in vivo AtTRB2 mediates the associations of HDT4 and HDA6 with telomeric repeats...
  19. Wang L, Kim J, Somers D. Transcriptional corepressor TOPLESS complexes with pseudoresponse regulator proteins and histone deacetylases to regulate circadian transcription. Proc Natl Acad Sci U S A. 2013;110:761-6 pubmed publisher
    ..Additionally, a complex of PRR9, TPL, and histone deacetylase 6, can form in vivo, implicating this tripartite association as a central repressor of circadian gene ..
  20. Hill K, Wang H, Perry S. A transcriptional repression motif in the MADS factor AGL15 is involved in recruitment of histone deacetylase complex components. Plant J. 2008;53:172-85 pubmed
    ..This motif mediates the association of AGL15 with SAP18, thus providing a possible mechanism for the role of AGL15 in regulating gene expression via recruitment of an HDAC complex. ..
  21. Chhun T, Chong S, Park B, Wong E, Yin J, Kim M, et al. HSI2 Repressor Recruits MED13 and HDA6 to Down-Regulate Seed Maturation Gene Expression Directly During Arabidopsis Early Seedling Growth. Plant Cell Physiol. 2016;57:1689-706 pubmed publisher
    ..The HSI2 C-terminal region interacts with HDA6, whose overexpression also reduces seed maturation gene expression and lipid accumulation...
  22. Zhu Z, An F, Feng Y, Li P, Xue L, A M, et al. Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:12539-44 pubmed publisher
    ..In addition, we find that JAZ proteins recruit an RPD3-type histone deacetylase (HDA6) as a corepressor that modulates histone acetylation, represses EIN3/EIL1-dependent transcription, and inhibits JA ..
  23. Luo M, Yu C, Chen F, Zhao L, Tian G, Liu X, et al. Histone deacetylase HDA6 is functionally associated with AS1 in repression of KNOX genes in arabidopsis. PLoS Genet. 2012;8:e1003114 pubmed publisher
    ..In this study, we demonstrated that AS1 can interact with the histone deacetylase HDA6 in vitro and in vivo...
  24. López González L, Mouriz A, Narro Diego L, Bustos R, Martínez Zapater J, Jarillo J, et al. Chromatin-dependent repression of the Arabidopsis floral integrator genes involves plant specific PHD-containing proteins. Plant Cell. 2014;26:3922-38 pubmed publisher
    ..SHL and EBS are widely conserved in plants but are absent in other eukaryotes, suggesting that the regulatory module mediated by these proteins could represent a distinct mechanism for gene expression control in plants. ..
  25. Perrella G, Lopez Vernaza M, Carr C, Sani E, Gosselé V, Verduyn C, et al. Histone deacetylase complex1 expression level titrates plant growth and abscisic acid sensitivity in Arabidopsis. Plant Cell. 2013;25:3491-505 pubmed publisher
    ..We show that HDC1 is a ubiquitously expressed nuclear protein that interacts with at least two deacetylases (HDA6 and HDA19), promotes histone deacetylation, and attenuates derepression of genes under water stress...