Gene Symbol: HAI1
Description: PP2C protein (Clade A protein phosphatases type 2C)
Alias: MNC17.13, MNC17_13, SAG113, highly ABA-induced PP2C gene 1, senescence associated gene 113, PP2C protein (Clade A protein phosphatases type 2C)
Species: thale cress

Top Publications

  1. Guo X, Deng K, Wang J, Yu D, Zhao Q, Liu X. Mutational analysis of Arabidopsis PP2CA2 involved in abscisic acid signal transduction. Mol Biol Rep. 2010;37:763-9 pubmed publisher
    ..The above results indicated that the pp2ca2 was an ABA-hyposensitive mutant. ..
  2. Li Z, Waadt R, Schroeder J. Release of GTP Exchange Factor Mediated Down-Regulation of Abscisic Acid Signal Transduction through ABA-Induced Rapid Degradation of RopGEFs. PLoS Biol. 2016;14:e1002461 pubmed publisher
  3. Lee S, Lan W, Buchanan B, Luan S. A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A. 2009;106:21419-24 pubmed publisher
    ..The findings are in keeping with a paradigm in which a protein kinase-phosphatase pair interacts physically with a target protein to couple a signal with a specific response. ..
  4. Huang D, Wu W, Abrams S, Cutler A. The relationship of drought-related gene expression in Arabidopsis thaliana to hormonal and environmental factors. J Exp Bot. 2008;59:2991-3007 pubmed publisher
    ..These analyses demonstrate that ABA-related stress responses are modulated by other environmental and developmental factors. ..
  5. Bhaskara G, Nguyen T, Verslues P. Unique drought resistance functions of the highly ABA-induced clade A protein phosphatase 2Cs. Plant Physiol. 2012;160:379-95 pubmed publisher
    ..acid (ABA) signaling roles; however, phenotypic roles of the remaining three "HAI" PP2Cs, Highly ABA-Induced1 (HAI1), AKT1-Interacting PP2C1/HAI2, and HAI3, have remained unclear...
  6. Umezawa T, Sugiyama N, Mizoguchi M, Hayashi S, Myouga F, Yamaguchi Shinozaki K, et al. Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis. Proc Natl Acad Sci U S A. 2009;106:17588-93 pubmed publisher
    ..Our results demonstrate that group A PP2Cs act as 'gatekeepers' of subclass III SnRK2s, unraveling an important regulatory mechanism of ABA signaling. ..
  7. Zhang K, Xia X, Zhang Y, Gan S. An ABA-regulated and Golgi-localized protein phosphatase controls water loss during leaf senescence in Arabidopsis. Plant J. 2012;69:667-78 pubmed publisher
    ..Here we report on the identification and functional analysis of a leaf senescence associated gene called SAG113. The RNA blot and GUS reporter analyses all show that SAG113 is expressed in senescing leaves and is induced by ..
  8. Antoni R, Gonzalez Guzman M, Rodriguez L, Rodrigues A, Pizzio G, Rodriguez P. Selective inhibition of clade A phosphatases type 2C by PYR/PYL/RCAR abscisic acid receptors. Plant Physiol. 2012;158:970-80 pubmed publisher
    ..Moreover, the differential sensitivity of the phosphatases At5g59220 and PP2CA to inhibition by ABA receptors reveals a functional specialization of PYR/PYL ABA receptors to preferentially inhibit certain PP2Cs. ..
  9. Ruckle M, Burgoon L, Lawrence L, Sinkler C, Larkin R. Plastids are major regulators of light signaling in Arabidopsis. Plant Physiol. 2012;159:366-90 pubmed publisher
    ..We conclude that the integration of light and plastid signaling regulates a number of END genes that help optimize chloroplast function and that at least some END genes affect photosynthesis-related gene expression...

More Information


  1. Xin Z, Zhao Y, Zheng Z. Transcriptome analysis reveals specific modulation of abscisic acid signaling by ROP10 small GTPase in Arabidopsis. Plant Physiol. 2005;139:1350-65 pubmed
    ..Our results suggest that ROP10 negatively regulates ABA responses by specifically and differentially modulating the ABA sensitivity of a subset of genes including protein kinases and zinc-finger family proteins. ..
  2. Zhao Y, Chan Z, Xing L, Liu X, Hou Y, Chinnusamy V, et al. The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Res. 2013;23:1380-95 pubmed publisher
    ..Our results show that PYL13 is not an ABA receptor but can modulate the ABA pathway by interacting with and inhibiting both the PYL receptors and the PP2C co-receptors...