Gene Symbol: GRF8
Description: general regulatory factor 8
Alias: 14-3-3 PROTEIN G-BOX FACTOR14 KAPPA, 14-3-3KAPPA, GF14 KAPPA, GF14 KAPPA ISOFORM, MNA5.16, MNA5_16, general regulatory factor 8, general regulatory factor 8
Species: thale cress
Products:     GRF8

Top Publications

  1. Ryu H, Kim K, Cho H, Park J, Choe S, Hwang I. Nucleocytoplasmic shuttling of BZR1 mediated by phosphorylation is essential in Arabidopsis brassinosteroid signaling. Plant Cell. 2007;19:2749-62 pubmed
    ..We propose that the spatial redistribution of BZR1 is critical for proper BR signaling in plant growth and development. ..
  2. Sepúlveda García E, Rocha Sosa M. The Arabidopsis F-box protein AtFBS1 interacts with 14-3-3 proteins. Plant Sci. 2012;195:36-47 pubmed publisher
    ..AICAR also affects Cullin1 (CUL1) modification by RUB1, which would provide an additional element to the effect of this compound on AtFBS1 stability. ..
  3. Gampala S, Kim T, He J, Tang W, Deng Z, Bai M, et al. An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell. 2007;13:177-89 pubmed
    ..This study demonstrates that multiple mechanisms are required for BR regulation of gene expression and plant growth. ..
  4. Shin R, Jez J, Basra A, Zhang B, Schachtman D. 14-3-3 proteins fine-tune plant nutrient metabolism. FEBS Lett. 2011;585:143-7 pubmed publisher
    ..Using a combination of methods, this work elucidates how 14-3-3s function as modulators of plant N and S metabolic pathways. ..
  5. Diaz C, Kusano M, Sulpice R, Araki M, Redestig H, Saito K, et al. Determining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes. BMC Syst Biol. 2011;5:192 pubmed publisher
    ..Taken together, our findings indicate that 14-3-3 proteins play roles as crucial tuners of multiple primary metabolic processes including TCA cycle and the shikimate pathway. ..
  6. Kanamaru K, Wang R, Su W, Crawford N. Ser-534 in the hinge 1 region of Arabidopsis nitrate reductase is conditionally required for binding of 14-3-3 proteins and in vitro inhibition. J Biol Chem. 1999;274:4160-5 pubmed
  7. Gao J, van Kleeff P, Oecking C, Li K, Erban A, Kopka J, et al. Light modulated activity of root alkaline/neutral invertase involves the interaction with 14-3-3 proteins. Plant J. 2014;80:785-96 pubmed publisher
    ..The nature of the light-induced signal that travels from the shoot to root and the question whether this signal is transmitted via cytosolic Ca(++) changes that activate calcium-dependent kinases, await further study. ..
  8. Alinsug M, Chen F, Luo M, Tai R, Jiang L, Wu K. Subcellular localization of class II HDAs in Arabidopsis thaliana: nucleocytoplasmic shuttling of HDA15 is driven by light. PLoS ONE. 2012;7:e30846 pubmed publisher
    ..Our study indicates that nucleocytoplasmic shuttling is indeed a hallmark for all eukaryotic Class II histone deacetylases...
  9. van Kleeff P, Jaspert N, Li K, Rauch S, Oecking C, de Boer A. Higher order Arabidopsis 14-3-3 mutants show 14-3-3 involvement in primary root growth both under control and abiotic stress conditions. J Exp Bot. 2014;65:5877-88 pubmed publisher

More Information


  1. Adams E, Diaz C, Hong J, Shin R. 14-3-3 proteins participate in light signaling through association with PHYTOCHROME INTERACTING FACTORs. Int J Mol Sci. 2014;15:22801-14 pubmed publisher
    ..Consequently, our results indicate that 14-3-3 proteins bind to PIFs and initiate photomorphogenesis in response to a light signal. ..
  2. Sehnke P, Henry R, Cline K, Ferl R. Interaction of a plant 14-3-3 protein with the signal peptide of a thylakoid-targeted chloroplast precursor protein and the presence of 14-3-3 isoforms in the chloroplast stroma. Plant Physiol. 2000;122:235-42 pubmed
    ..These isoforms represent two distinct phylogenetic 14-3-3 groupings. These data suggest a novel interorganellar role for these phylogenetically distinct 14-3-3 proteins. ..
  3. Ryu H, Cho H, Kim K, Hwang I. Phosphorylation dependent nucleocytoplasmic shuttling of BES1 is a key regulatory event in brassinosteroid signaling. Mol Cells. 2010;29:283-90 pubmed publisher
    ..Taken together, our results indicate that the spatial redistribution of BES1 is important for regulation of the BR signaling output. ..
  4. Liu Z, Jia Y, Ding Y, Shi Y, Li Z, Guo Y, et al. Plasma Membrane CRPK1-Mediated Phosphorylation of 14-3-3 Proteins Induces Their Nuclear Import to Fine-Tune CBF Signaling during Cold Response. Mol Cell. 2017;66:117-128.e5 pubmed publisher
    ..Thus, our study reveals that the CRPK1-14-3-3 module transduces the cold signal from the plasma membrane to the nucleus to modulate CBF stability, which ensures a faithfully adjusted response to cold stress of plants. ..