Gene Symbol: GID1A
Description: alpha/beta-Hydrolases superfamily protein
Alias: ATGID1A, GA INSENSITIVE DWARF1A, T12H1.8, T12H1_8, alpha/beta-Hydrolases superfamily protein
Species: thale cress

Top Publications

  1. Griffiths J, Murase K, Rieu I, Zentella R, Zhang Z, Powers S, et al. Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell. 2006;18:3399-414 pubmed
    ..Although single mutants developed normally, gid1a gid1c and gid1a gid1b displayed reduced stem height and lower male fertility, respectively, indicating some ..
  2. Willige B, Ghosh S, Nill C, Zourelidou M, Dohmann E, Maier A, et al. The DELLA domain of GA INSENSITIVE mediates the interaction with the GA INSENSITIVE DWARF1A gibberellin receptor of Arabidopsis. Plant Cell. 2007;19:1209-20 pubmed
    ..GAI DELLA domain mutants is explained in all cases by the inability of the mutant proteins to interact with the GID1A GA receptor...
  3. Suzuki H, Park S, Okubo K, Kitamura J, Ueguchi Tanaka M, Iuchi S, et al. Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants. Plant J. 2009;60:48-55 pubmed publisher
    ..Of the three, only a double loss-of-function mutant (atgid1a atgid1c) shows a dwarf phenotype, while other double and all single mutants show no abnormality in height...
  4. Ariizumi T, Hauvermale A, Nelson S, Hanada A, Yamaguchi S, Steber C. Lifting della repression of Arabidopsis seed germination by nonproteolytic gibberellin signaling. Plant Physiol. 2013;162:2125-39 pubmed publisher
    ..After-ripening results in increased GA accumulation and GID1a-dependent GA signaling, suggesting that after-ripening triggers GA-stimulated GID1-GA-DELLA protein complex ..
  5. Zentella R, Zhang Z, Park M, Thomas S, Endo A, Murase K, et al. Global analysis of della direct targets in early gibberellin signaling in Arabidopsis. Plant Cell. 2007;19:3037-57 pubmed
    ..In addition, one of the putative DELLA targets, XERICO, promotes accumulation of abscisic acid (ABA) that antagonizes GA effects. Therefore, DELLA may restrict GA-promoted processes by modulating both GA and ABA pathways. ..
  6. Nakajima M, Shimada A, Takashi Y, Kim Y, Park S, Ueguchi Tanaka M, et al. Identification and characterization of Arabidopsis gibberellin receptors. Plant J. 2006;46:880-9 pubmed
    Three gibberellin (GA) receptor genes (AtGID1a, AtGID1b and AtGID1c), each an ortholog of the rice GA receptor gene (OsGID1), were cloned from Arabidopsis, and the characteristics of their recombinant proteins were examined...
  7. Ariizumi T, Murase K, Sun T, Steber C. Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1. Plant Cell. 2008;20:2447-59 pubmed publisher
    ..degradation requires GA biosynthesis, three functionally redundant GA receptors GIBBERELLIN INSENSITIVE DWARF1 (GID1a, b, and c), and the SLEEPY1 (SLY1) F-box subunit of an SCF E3 ubiquitin ligase...
  8. Iuchi S, Suzuki H, Kim Y, Iuchi A, Kuromori T, Ueguchi Tanaka M, et al. Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal. Plant J. 2007;50:958-66 pubmed
    Arabidopsis carries three receptor genes for the phytohormone gibberellin (GA), AtGID1a, AtGID1b and AtGID1c...
  9. Murase K, Hirano Y, Sun T, Hakoshima T. Gibberellin-induced DELLA recognition by the gibberellin receptor GID1. Nature. 2008;456:459-63 pubmed publisher
    ..Here we present the crystal structure of a ternary complex of Arabidopsis thaliana GID1A, a bioactive gibberellin and the amino-terminal DELLA domain of GAI...

More Information


  1. Nemoto K, Ramadan A, Arimura G, Imai K, Tomii K, Shinozaki K, et al. Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation. Nat Commun. 2017;8:1004 pubmed publisher
    ..degradation of GID1, and that the TAGK2 plant Tyr-kinase is a target of genistein and inhibits GARU-GID1A interactions by phosphorylation of GARU at Tyr321. Genistein induces degradation of GID1 and accumulation of DELLA...
  2. Yamaguchi I, Nakajima M, Park S. Trails to the gibberellin receptor, GIBBERELLIN INSENSITIVE DWARF1. Biosci Biotechnol Biochem. 2016;80:1029-36 pubmed publisher
    ..Unpublished data of the gibberellin-binding protein in the seedlings of adzuki bean (Vigna angularis) are also included, suggesting that the active principle of the gibberellin-binding protein was a GID1 homolog. ..
  3. Sheerin D, Buchanan J, Kirk C, Harvey D, Sun X, Spagnuolo J, et al. Inter- and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1. Biochem J. 2011;435:629-39 pubmed publisher
    ..of the DELLA protein RGL1 (REPRESSOR OF GA1-3-LIKE 1) of Arabidopsis thaliana with the gibberellin receptor GID1A (GIBBERELLIC ACID-INSENSITIVE DWARF-1A) and the F-box protein SLY1 (SLEEPY1)...
  4. Middleton A, Ubeda Tomas S, Griffiths J, Holman T, Hedden P, Thomas S, et al. Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling. Proc Natl Acad Sci U S A. 2012;109:7571-6 pubmed publisher
    ..Moreover, although the contribution of other individual feedback loops seems relatively small, GID1 and DELLA transcriptional regulation acts synergistically with GA20ox feedback. ..
  5. Hao G, Yang S, Yang G, Zhan C. Computational gibberellin-binding channel discovery unraveling the unexpected perception mechanism of hormone signal by gibberellin receptor. J Comput Chem. 2013;34:2055-64 pubmed publisher
  6. Hauvermale A, Ariizumi T, Steber C. The roles of the GA receptors GID1a, GID1b, and GID1c in sly1-independent GA signaling. Plant Signal Behav. 2014;9:e28030 pubmed
    ..Based on comparison of gid1 multiple mutants to sly1 gid1 mutants, GID1a is the primary GA receptor stimulating stem elongation in proteolytic and non-proteolytic signaling, and ..
  7. Voegele A, Linkies A, Muller K, Leubner Metzger G. Members of the gibberellin receptor gene family GID1 (GIBBERELLIN INSENSITIVE DWARF1) play distinct roles during Lepidium sativum and Arabidopsis thaliana seed germination. J Exp Bot. 2011;62:5131-47 pubmed publisher
    ..Three GIBBERELLIN INSENSITIVE DWARF1 (GID1) GA receptors are known in Arabidopsis thaliana: GID1a, GID1b, and GID1c...
  8. Nelis S, Conti L, Zhang C, Sadanandom A. A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction. Plant Signal Behav. 2015;10:e987528 pubmed publisher
    ..This evidence suggests that manipulating the SIM motif in the GA receptor may provide a possible route to developing stress tolerant crops plants. ..
  9. Conti L, Nelis S, Zhang C, Woodcock A, Swarup R, Galbiati M, et al. Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin. Dev Cell. 2014;28:102-10 pubmed publisher
    ..We conclude that plants have developed a GA-independent mechanism to control growth. ..
  10. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, et al. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature. 2008;451:475-9 pubmed publisher
  11. Livne S, Weiss D. Cytosolic activity of the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1A. Plant Cell Physiol. 2014;55:1727-33 pubmed publisher
    Arabidopsis has three gibberellin receptors, GIBBERELLIN INSENSITIVE DWARF1 A (GID1A), GID1B and GID1C. All GID1s are localized to the nucleus but have also been detected in the cytoplasm...
  12. Hauvermale A, Tuttle K, Takebayashi Y, Seo M, Steber C. Loss of Arabidopsis thaliana Seed Dormancy is Associated with Increased Accumulation of the GID1 GA Hormone Receptors. Plant Cell Physiol. 2015;56:1773-85 pubmed publisher
    ..overexpression of the GA receptor GID1 (GIBBERELLIN-INSENSITIVE DWARF1) enhanced this dormancy loss, and because gid1a gid1b gid1c triple mutants show decreased germination, the effects of dormancy-breaking treatments on GID1 mRNA ..
  13. Marín de la Rosa N, Alabadi D, Blázquez M, Arana M. Integrating circadian and gibberellin signaling in Arabidopsis: possible links between the circadian clock and the AtGID1 transcription. Plant Signal Behav. 2011;6:1411-3 pubmed
    ..the circadian regulation of gibberellin (GA) signaling, through transcriptional control of GA receptor genes (GID1a and GID1b)...
  14. Gallego Giraldo C, Hu J, Urbez C, Gomez M, Sun T, Perez Amador M. Role of the gibberellin receptors GID1 during fruit-set in Arabidopsis. Plant J. 2014;79:1020-1032 pubmed publisher
    ..To understand the role of the three GA receptor genes (GID1A, GID1B and GID1C) in Arabidopsis during fruit initiation, we have examined their temporal and spatial localization,..