Gene Symbol: GG1
Description: Ggamma-subunit 1
Alias: AGG1, ATAGG1, Ggamma-subunit 1, HETEROTRIMERIC G PROTEIN GAMMA-SUBUNIT, Ggamma-subunit 1
Species: thale cress

Top Publications

  1. Zeng Q, Wang X, Running M. Dual lipid modification of Arabidopsis Ggamma-subunits is required for efficient plasma membrane targeting. Plant Physiol. 2007;143:1119-31 pubmed
    ..Here we demonstrate that the two heterotrimeric G-protein gamma-subunits from Arabidopsis (Arabidopsis thaliana), AGG1 and AGG2, are prenylated, and AGG2 is S-acylated...
  2. Adjobo Hermans M, Goedhart J, Gadella T. Plant G protein heterotrimers require dual lipidation motifs of Galpha and Ggamma and do not dissociate upon activation. J Cell Sci. 2006;119:5087-97 pubmed
    ..The Arabidopsis Gbeta subunit, AGbeta1, and the Ggamma subunit, AGG1, were dependent upon each other for tethering to the plasma membrane...
  3. Trusov Y, Zhang W, Assmann S, Botella J. Ggamma1 + Ggamma2 not equal to Gbeta: heterotrimeric G protein Ggamma-deficient mutants do not recapitulate all phenotypes of Gbeta-deficient mutants. Plant Physiol. 2008;147:636-49 pubmed publisher
    ..The Arabidopsis (Arabidopsis thaliana) genome contains one Galpha (GPA1), one Gbeta (AGB1), and two Ggamma subunit (AGG1 and AGG2) genes...
  4. Mason M, Botella J. Completing the heterotrimer: isolation and characterization of an Arabidopsis thaliana G protein gamma-subunit cDNA. Proc Natl Acad Sci U S A. 2000;97:14784-8 pubmed
    ..One positive clone (AGG1) was isolated several times; it displays significant homology to the conserved domains of mammalian gamma-subunits...
  5. Mason M, Botella J. Isolation of a novel G-protein gamma-subunit from Arabidopsis thaliana and its interaction with Gbeta. Biochim Biophys Acta. 2001;1520:147-53 pubmed
    ..The predicted AGG2 protein sequence shows 48% identity to the first identified Arabidopsis Ggamma-subunit, AGG1. Furthermore, AGG2 contains all of the conserved characteristics of gamma-subunits including a small size (100 ..
  6. Delgado Cerezo M, Sánchez Rodríguez C, Escudero V, Miedes E, Fernández P, Jorda L, et al. Arabidopsis heterotrimeric G-protein regulates cell wall defense and resistance to necrotrophic fungi. Mol Plant. 2012;5:98-114 pubmed publisher
    ..G?/AGB1 forms an obligate dimer with either one of the Arabidopsis G? subunits (?1/AGG1 and ?2/AGG2)...
  7. Tsugama D, Liu S, Takano T. Arabidopsis heterotrimeric G protein ? subunit, AGB1, regulates brassinosteroid signalling independently of BZR1. J Exp Bot. 2013;64:3213-23 pubmed publisher
    ..AGB1 interacted with BIN2 in vitro, but did not affect the phosphorylation state of BIN2. The results suggest that AGB1 interacts with BIN2, but regulates the BR signalling in a BZR1-independent manner. ..
  8. Aranda Sicilia M, Trusov Y, Maruta N, Chakravorty D, Zhang Y, Botella J. Heterotrimeric G proteins interact with defense-related receptor-like kinases in Arabidopsis. J Plant Physiol. 2015;188:44-8 pubmed publisher
    ..At the same time, no interaction was detected with the non-RD RLK FLS2. We hypothesize that G-proteins mediate signal transduction immediately downstream of the pathogenesis-related RLKs. ..
  9. Wang S, Assmann S, Fedoroff N. Characterization of the Arabidopsis heterotrimeric G protein. J Biol Chem. 2008;283:13913-22 pubmed publisher

More Information


  1. Maruta N, Trusov Y, Brenya E, Parekh U, Botella J. Membrane-localized extra-large G proteins and Gbg of the heterotrimeric G proteins form functional complexes engaged in plant immunity in Arabidopsis. Plant Physiol. 2015;167:1004-16 pubmed
    ..Accordingly, XLGs expand the repertoire of heterotrimeric G proteins in plants and reveal a higher level of diversity in heterotrimeric G protein signaling. ..
  2. Olejnik K, Bucholc M, Anielska Mazur A, Lipko A, Kujawa M, Modzelan M, et al. Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein. Acta Biochim Pol. 2011;58:609-16 pubmed
    ..In vitro interaction between RACK1A and the AGG1 and AGG2 gamma subunits of the signal transducing heterotrimeric G protein was also detected and confirmed in BiFC ..
  3. Heo J, Sung S, Assmann S. Ca2+-dependent GTPase, extra-large G protein 2 (XLG2), promotes activation of DNA-binding protein related to vernalization 1 (RTV1), leading to activation of floral integrator genes and early flowering in Arabidopsis. J Biol Chem. 2012;287:8242-53 pubmed publisher
    ..Thus, a Ca(2+)-dependent G protein, XLG2, promotes RTV1 DNA binding activity for a subset of floral integrator genes and contributes to floral transition. ..
  4. Wang S, Narendra S, Fedoroff N. Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response. Proc Natl Acad Sci U S A. 2007;104:3817-22 pubmed
  5. Booker K, Schwarz J, Garrett M, Jones A. Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex. PLoS ONE. 2010;5: pubmed publisher
    ..The bimodality can be further resolved into the processes of lateral root primordia formation and lateral root emergence, from which a model integrating these signals is proposed. ..
  6. Thung L, Chakravorty D, Trusov Y, Jones A, Botella J. Signaling specificity provided by the Arabidopsis thaliana heterotrimeric G-protein ? subunits AGG1 and AGG2 is partially but not exclusively provided through transcriptional regulation. PLoS ONE. 2013;8:e58503 pubmed publisher
    ..While two of the ? subunits, AGG1 and AGG2 have been shown to provide functional selectivity to the Gß? dimer in Arabidopsis, it is unclear if such ..
  7. Chakravorty D, Botella J. Over-expression of a truncated Arabidopsis thaliana heterotrimeric G protein gamma subunit results in a phenotype similar to alpha and beta subunit knockouts. Gene. 2007;393:163-70 pubmed