Gene Symbol: GCR1
Description: G-protein-coupled receptor 1
Alias: F11A17.17, F11A17_17, G-protein-coupled receptor 1, G-protein-coupled receptor 1
Species: thale cress

Top Publications

  1. Pandey S, Chen J, Jones A, Assmann S. G-protein complex mutants are hypersensitive to abscisic acid regulation of germination and postgermination development. Plant Physiol. 2006;141:243-56 pubmed
    ..thaliana) Galpha subunit (GPA1), the Gbeta subunit (AGB1), and the candidate G-protein-coupled receptor (GCR1) in ABA signaling during germination and early seedling development, we utilized knockout mutants lacking one or ..
  2. Apone F, Alyeshmerni N, Wiens K, Chalmers D, Chrispeels M, Colucci G. The G-protein-coupled receptor GCR1 regulates DNA synthesis through activation of phosphatidylinositol-specific phospholipase C. Plant Physiol. 2003;133:571-9 pubmed
    ..only known Galpha-subunit of the heterotrimeric G-protein (GPA1) and the only putative G-protein coupled receptor (GCR1) of plants has never been shown...
  3. Warpeha K, Lateef S, Lapik Y, Anderson M, Lee B, Kaufman L. G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis. Plant Physiol. 2006;140:844-55 pubmed
    ..Insertion mutagenesis confirms that GPA1 and the sole canonical G-protein-coupled receptor (GCR1) in Arabidopsis also have a role in this blue light-mediated event...
  4. Pandey S, Assmann S. The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. Plant Cell. 2004;16:1616-32 pubmed
    ..One Arabidopsis gene, GCR1, encodes a protein with significant sequence similarity to nonplant GPCRs and a predicted 7-transmembrane domain ..
  5. Chen J, Pandey S, Huang J, Alonso J, Ecker J, Assmann S, et al. GCR1 can act independently of heterotrimeric G-protein in response to brassinosteroids and gibberellins in Arabidopsis seed germination. Plant Physiol. 2004;135:907-15 pubmed
    ..Arabidopsis GCR1 has a predicted 7TM-spanning domain and other features characteristic of 7TM receptors...
  6. Liu F, Bian Z, Jia Z, Zhao Q, Song S. The GCR1 and GPA1 participate in promotion of Arabidopsis primary root elongation induced by N-acyl-homoserine lactones, the bacterial quorum-sensing signals. Mol Plant Microbe Interact. 2012;25:677-83 pubmed publisher
    ..The genetic analysis revealed that the T-DNA insertional mutants of gcr1, encoding a G-protein-coupled receptor GCR1, were insensitive to 3OC6-HSL or 3OC8-HSL in assays of root growth...
  7. Plakidou Dymock S, Dymock D, Hooley R. A higher plant seven-transmembrane receptor that influences sensitivity to cytokinins. Curr Biol. 1998;8:315-24 pubmed
    ..Using information in the dbEST database of expressed sequence tags, we isolated an Arabidopsis thaliana gene (GCR1) that encodes a protein with seven predicted membrane-spanning domains and other features characteristic of 7TM ..
  8. Warpeha K, Upadhyay S, Yeh J, Adamiak J, Hawkins S, Lapik Y, et al. The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and abscisic acid responses in Arabidopsis. Plant Physiol. 2007;143:1590-600 pubmed
    ..The chain consists of GCR1 (the sole Arabidopsis protein coding for a potential G-protein-coupled receptor), GPA1 (the sole Arabidopsis Galpha-..
  9. Colucci G, Apone F, Alyeshmerni N, Chalmers D, Chrispeels M. GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering. Proc Natl Acad Sci U S A. 2002;99:4736-41 pubmed
    ..We observed that expression of GCR1, the gene encoding the only known (but still putative) G protein-coupled receptor of Arabidopsis thaliana, is ..

More Information


  1. Liu X, Yue Y, Li B, Nie Y, Li W, Wu W, et al. A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science. 2007;315:1712-6 pubmed
    ..The binding of ABA to the receptor leads to the dissociation of the receptor-GPA1 complex in yeast. Our results demonstrate that this G protein-coupled receptor is a plasma membrane ABA receptor. ..
  2. Chakraborty N, Sharma P, Kanyuka K, Pathak R, Choudhury D, Hooley R, et al. G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana. Plant Mol Biol. 2015;89:559-76 pubmed publisher
    ..but the mechanisms of signal-response coupling and the roles of G-protein coupled receptors in general and GCR1 in particular, remain poorly understood...