Gene Symbol: GBF1
Description: G-box binding factor 1
Alias: AP22.21, AP22_21, AtGBF1, G-box binding factor 1, G-box binding factor 1
Species: thale cress

Top Publications

  1. Schindler U, Menkens A, Beckmann H, Ecker J, Cashmore A. Heterodimerization between light-regulated and ubiquitously expressed Arabidopsis GBF bZIP proteins. EMBO J. 1992;11:1261-73 pubmed
    ..Here we report the isolation of three Arabidopsis thaliana cDNA clones encoding GBF proteins referred to as GBF1, GBF2 and GBF3. GBF1 and GBF2 mRNA is present in light and dark grown leaves as well as in roots...
  2. Mallappa C, Singh A, Ram H, Chattopadhyay S. GBF1, a transcription factor of blue light signaling in Arabidopsis, is degraded in the dark by a proteasome-mediated pathway independent of COP1 and SPA1. J Biol Chem. 2008;283:35772-82 pubmed publisher
    Arabidopsis GBF1/ZBF2 is a bZIP transcription factor that plays dual but opposite regulatory roles in cryptochrome-mediated blue light signaling...
  3. Shaikhali J, Norén L, de Dios Barajas López J, Srivastava V, König J, Sauer U, et al. Redox-mediated mechanisms regulate DNA binding activity of the G-group of basic region leucine zipper (bZIP) transcription factors in Arabidopsis. J Biol Chem. 2012;287:27510-25 pubmed publisher
    ..Although AtbZIP16 and its close homologues AtbZIP68 and AtGBF1 bind the G-box, they do not bind the mutated half-sites of the G-box palindrome...
  4. Singh A, Ram H, Abbas N, Chattopadhyay S. Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana. J Biol Chem. 2012;287:25995-6009 pubmed publisher
    Arabidopsis bZIP transcription factor, GBF1, acts as a differential regulator of cryptochrome-mediated blue light signaling...
  5. Terzaghi W, Bertekap R, Cashmore A. Intracellular localization of GBF proteins and blue light-induced import of GBF2 fusion proteins into the nucleus of cultured Arabidopsis and soybean cells. Plant J. 1997;11:967-82 pubmed
    ..To study GBFs, a polyclonal antibody was raised against GBF1 expressed in bacteria. This antibody also recognized GBF2 and GBF3...
  6. Shen H, Cao K, Wang X. AtbZIP16 and AtbZIP68, two new members of GBFs, can interact with other G group bZIPs in Arabidopsis thaliana. BMB Rep. 2008;41:132-8 pubmed
    ..putative G group bZIP transcription factors in Arabidopsis thaliana, the other three members of G group bZIPs are GBF1-3 which can bind G-box...
  7. Tamai H, Iwabuchi M, Meshi T. Arabidopsis GARP transcriptional activators interact with the Pro-rich activation domain shared by G-box-binding bZIP factors. Plant Cell Physiol. 2002;43:99-107 pubmed
    ..yeast two-hybrid assays and in vitro binding assays indicated that GPRI1 can interact with the Pro-rich regions of GBF1 and GBF3. GPRI2 interacted with the Pro-rich region of GBF1. GPRI1 and GPRI2 transactivated transcription in yeast...
  8. Prasad V, Gupta N, Nandi A, Chattopadhyay S. HY1 genetically interacts with GBF1 and regulates the activity of the Z-box containing promoters in light signaling pathways in Arabidopsis thaliana. Mech Dev. 2012;129:298-307 pubmed publisher
    ..b>GBF1/ZBF2 is a G/Z-box binding bZIP protein that plays a dual but opposite regulatory roles in blue light-mediated ..
  9. Ram H, Priya P, Jain M, Chattopadhyay S. Genome-wide DNA binding of GBF1 is modulated by its heterodimerizing protein partners, HY5 and HYH. Mol Plant. 2014;7:448-51 pubmed publisher

More Information


  1. Richter S, Müller L, Stierhof Y, Mayer U, Takada N, Kost B, et al. Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors. Nat Cell Biol. 2011;14:80-6 pubmed publisher
    ..Here we show that in Arabidopsis, GBF1-related exchange factors for the ARF GTPases (ARF GEFs) GNOM and GNL2 play essential roles in polar tip growth of ..
  2. Iglesias Fernández R, Wozny D, Iriondo de Hond M, Oñate Sánchez L, Carbonero P, Barrero Sicilia C. The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1. J Exp Bot. 2014;65:2009-21 pubmed publisher
    ..genes within the Brassicaceae species analysed, and, as its DNA-interacting protein, the G-Box Binding Factor1 (GBF1)...
  3. Shaikhali J. GIP1 protein is a novel cofactor that regulates DNA-binding affinity of redox-regulated members of bZIP transcription factors involved in the early stages of Arabidopsis development. Protoplasma. 2015;252:867-83 pubmed publisher
    ..and Arabidopsis GBF3, is a plant specific protein that reduces DNA-binding activity of AtbZIP16, AtbZIP68, and AtGBF1 under non-reducing conditions through direct physical interaction shown by the yeast two-hybrid and pull-down ..
  4. Maurya J, Sethi V, Gangappa S, Gupta N, Chattopadhyay S. Interaction of MYC2 and GBF1 results in functional antagonism in blue light-mediated Arabidopsis seedling development. Plant J. 2015;83:439-50 pubmed publisher
    ..MYC2 and GBF1 belong to bHLH and bZIP classes of transcription factors, respectively, and function in cryptochrome-mediated blue ..