Gene Symbol: GAPA
Description: glyceraldehyde 3-phosphate dehydrogenase A subunit
Alias: GAPA-1, GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE A SUBUNIT, GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE A SUBUNIT 1, GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A SUBUNIT, glyceraldehyde 3-phosphate dehydrogenase A subunit, glyceraldehyde 3-phosphate dehydrogenase A subunit
Species: thale cress
Shih M, Heinrich P, Goodman H. Intron existence predated the divergence of eukaryotes and prokaryotes. Science. 1988;242:1164-6 pubmed
Nucleotide sequences for the nuclear genes encoding chloroplast (GapA and GapB) and cytosolic (GapC) glyceraldehyde-3-phosphate dehydrogenases (GAPDHs) from Arabidopsis thaliana were determined...
Marri L, Sparla F, Pupillo P, Trost P. Co-ordinated gene expression of photosynthetic glyceraldehyde-3-phosphate dehydrogenase, phosphoribulokinase, and CP12 in Arabidopsis thaliana. J Exp Bot. 2005;56:73-80 pubmed
..The expression of four GAPDH genes was analysed, i.e. GapA-1 and GapB for photosynthetic GAPDH of chloroplasts (NAD(P)-dependent), GapC-1 for cytosolic GAPDH, and GapCp-1 for ..
Baek D, Jin Y, Jeong J, Lee H, Moon H, Lee J, et al
. Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase. Phytochemistry. 2008;69:333-8 pubmed
..Together, our results indicate that GAPDH controls generation of H(2)O(2) by Bax and heat shock, which in turn suppresses cell death in yeast and plant cells. ..
Fermani S, Trivelli X, Sparla F, Thumiger A, Calvaresi M, Marri L, et al
. Conformational selection and folding-upon-binding of intrinsically disordered protein CP12 regulate photosynthetic enzymes assembly. J Biol Chem. 2012;287:21372-83 pubmed publisher
..Formation of several hydrogen bonds compensates the entropic cost of CP12 fixation and terminates the interaction mechanism that contributes to carbon assimilation control. ..
Marri L, Trost P, Pupillo P, Sparla F. Reconstitution and properties of the recombinant glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase supramolecular complex of Arabidopsis. Plant Physiol. 2005;139:1433-43 pubmed
..PRK and CP12, but not GapA (A(4) isoform of GAPDH), are redox-sensitive proteins. PRK was reversibly inhibited by oxidation...
Marri L, Trost P, Trivelli X, Gonnelli L, Pupillo P, Sparla F. Spontaneous assembly of photosynthetic supramolecular complexes as mediated by the intrinsically unstructured protein CP12. J Biol Chem. 2008;283:1831-8 pubmed
..The redox dependence of events leading to supramolecular complexes is consistent with a role of CP12 in coordinating the reversible inactivation of chloroplast enzymes A(4)-GAPDH and PRK during darkness in photosynthetic tissues. ..