Gene Symbol: FWA
Species: thale cress

Top Publications

  1. Kinoshita T, Miura A, Choi Y, Kinoshita Y, Cao X, Jacobsen S, et al. One-way control of FWA imprinting in Arabidopsis endosperm by DNA methylation. Science. 2004;303:521-3 pubmed
    The Arabidopsis FWA gene was initially identified from late-flowering epigenetic mutants that show ectopic FWA expression associated with heritable hypomethylation of repeats around transcription starting sites...
  2. Fujimoto R, Kinoshita Y, Kawabe A, Kinoshita T, Takashima K, Nordborg M, et al. Evolution and control of imprinted FWA genes in the genus Arabidopsis. PLoS Genet. 2008;4:e1000048 pubmed publisher
    ..b>FWA is an imprinted gene in Arabidopsis thaliana expressed specifically in the female gametophyte and endosperm...
  3. Jullien P, Kinoshita T, Ohad N, Berger F. Maintenance of DNA methylation during the Arabidopsis life cycle is essential for parental imprinting. Plant Cell. 2006;18:1360-72 pubmed
    ..thaliana, maternal imprinting has been clearly demonstrated for the Polycomb group gene MEDEA (MEA) and for FWA. Direct repeats upstream of FWA are subject to DNA methylation...
  4. Chan S, Zhang X, Bernatavichute Y, Jacobsen S. Two-step recruitment of RNA-directed DNA methylation to tandem repeats. PLoS Biol. 2006;4:e363 pubmed
    Tandem repeat sequences are frequently associated with gene silencing phenomena. The Arabidopsis thaliana FWA gene contains two tandem repeats and is an efficient target for RNA-directed de novo DNA methylation when it is transformed ..
  5. Kinoshita Y, Saze H, Kinoshita T, Miura A, Soppe W, Koornneef M, et al. Control of FWA gene silencing in Arabidopsis thaliana by SINE-related direct repeats. Plant J. 2007;49:38-45 pubmed
    A unique feature of late-flowering fwa epigenetic mutations is that the phenotype is caused by ectopic expression of the homeobox gene FWA...
  6. Fujimoto R, Sasaki T, Kudoh H, Taylor J, Kakutani T, Dennis E. Epigenetic variation in the FWA gene within the genus Arabidopsis. Plant J. 2011;66:831-43 pubmed publisher
    b>fwa is a late flowering epi-mutant in Arabidopsis thaliana...
  7. Ruiz Garcia L, Madueno F, Wilkinson M, Haughn G, Salinas J, Martínez Zapater J. Different roles of flowering-time genes in the activation of floral initiation genes in Arabidopsis. Plant Cell. 1997;9:1921-34 pubmed
    We have analyzed double mutants that combine late-flowering mutations at four flowering-time loci (FVE, FPA, FWA, and FT) with mutations at the LEAFY (LFY), APETALA1 (AP1), and TERMINAL FLOWER1 (TFL1) loci involved in the floral ..
  8. Soppe W, Bentsink L, Koornneef M. The early-flowering mutant efs is involved in the autonomous promotion pathway of Arabidopsis thaliana. Development. 1999;126:4763-70 pubmed
    ..In a screen for early flowering, after mutagenesis of the late-flowering fwa mutant of Arabidopsis thaliana, the early flowering in short days (efs) mutant was identified...
  9. Le Masson I, Jauvion V, Bouteiller N, Rivard M, Elmayan T, Vaucheret H. Mutations in the Arabidopsis H3K4me2/3 demethylase JMJ14 suppress posttranscriptional gene silencing by decreasing transgene transcription. Plant Cell. 2012;24:3603-12 pubmed publisher
    ..Removing JMJ14 likely allows other H3K4 demethylases encoded by the Arabidopsis thaliana genome to act on transgenes and reduce transcription levels, thus preventing the triggering of S-PTGS. ..

More Information


  1. Kawanabe T, Fujimoto R. Inflorescence abnormalities occur with overexpression of Arabidopsis lyrata FT in the fwa mutant of Arabidopsis thaliana. Plant Sci. 2011;181:496-503 pubmed publisher
    ..b>fwa is a late-flowering mutant, and this phenotype is due to ectopic FWA expression caused by hypomethylation at the ..
  2. Ikeda Y, Kobayashi Y, Yamaguchi A, Abe M, Araki T. Molecular basis of late-flowering phenotype caused by dominant epi-alleles of the FWA locus in Arabidopsis. Plant Cell Physiol. 2007;48:205-20 pubmed
    The late-flowering phenotype of dominant fwa mutants is caused by hypomethylation in the FWA locus leading to ectopic expression of a homeodomain leucine zipper (HD-ZIP) protein...
  3. Jiang D, Yang W, He Y, Amasino R. Arabidopsis relatives of the human lysine-specific Demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition. Plant Cell. 2007;19:2975-87 pubmed
    ..in chromatin of the floral repressor FLOWERING LOCUS C (FLC) and the sporophytically silenced floral repressor FWA. Two of the homologs, LSD1-LIKE1 (LDL1) and LSD1-LIKE2 (LDL2), act in partial redundancy with FLOWERING LOCUS D (..