Gene Symbol: FUS9
Description: Ubiquitin-conjugating enzyme family protein
Alias: CIN4, CONSTITUTIVE PHOTOMORPHOGENIC 10, COP10, CYTOKININ-INSENSITIVE 4, E2 UBIQUITIN-CONJUGATING ENZYME, EMB144, EMBRYO DEFECTIVE 144, FUSCA 9, Ubiquitin-conjugating enzyme family protein
Species: thale cress
Suzuki G, Yanagawa Y, Kwok S, Matsui M, Deng X. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 2002;16:554-9 pubmed
..Here we report that COP10 encodes a protein similar to ubiquitin-conjugating enzyme (E2) variant proteins (UEV)...
Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau O, Yanagawa Y, et al
. Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time. Plant Cell. 2010;22:108-23 pubmed publisher
..Thus, a series of CUL4-DDB1-COP1-SPA E3 ligase complexes may mediate the repression of photomorphogenesis and, possibly, of flowering time. ..
Wei N, Kwok S, von Arnim A, Lee A, McNellis T, Piekos B, et al
. Arabidopsis COP8, COP10, and COP11 genes are involved in repression of photomorphogenic development in darkness. Plant Cell. 1994;6:629-43 pubmed
..photomorphogenic development in darkness resulted in the identification of three new loci designated COP8, COP10, and COP11...
Yanagawa Y, Sullivan J, Komatsu S, Gusmaroli G, Suzuki G, Yin J, et al
. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev. 2004;18:2172-81 pubmed
b>COP10 is a ubiquitin-conjugating enzyme variant (UEV), which is thought to act together with COP1, DET1, and the COP9 signalosome (CSN) in Arabidopsis to repress photomorphogenesis...
Chen H, Shen Y, Tang X, Yu L, Wang J, Guo L, et al
. Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development. Plant Cell. 2006;18:1991-2004 pubmed
..Furthermore, CUL4 exhibits a synergistic genetic interaction with COP10 and DET1. Therefore, this CUL4-based E3 ligase is essential for the repression of photomorphogenesis...
Lau O, Deng X. Effect of Arabidopsis COP10 ubiquitin E2 enhancement activity across E2 families and functional conservation among its canonical homologues. Biochem J. 2009;418:683-90 pubmed publisher
Arabidopsis thaliana COP10 (constitutive photomorphogenic 10) is a UEV [Ub (ubiquitin)-conjugating enzyme (E2) variant protein] that is required for repression of seedling photomorphogenesis in darkness...
Delgado D, Ballesteros I, Torres Contreras J, Mena M, Fenoll C. Dynamic analysis of epidermal cell divisions identifies specific roles for COP10 in Arabidopsis stomatal lineage development. Planta. 2012;236:447-61 pubmed publisher
..b>CONSTITUTIVE PHOTOMORPHOGENIC 10 (COP10) is an important component of this switch, its loss of function producing stomatal clusters...
Kang M, Yoo S, Kwon H, Lee B, Cho J, Noh Y, et al
. Negative regulatory roles of DE-ETIOLATED1 in flowering time in Arabidopsis. Sci Rep. 2015;5:9728 pubmed publisher
..Thus, we propose that DET1 is a strong repressor of flowering and has a pivotal role in maintaining photoperiod sensitivity in the regulation of flowering time. ..
Delgado D, Ballesteros I, Mena M, Fenoll C. Roles of constitutive photomorphogenic 10 in Arabidopsis stomata development. Plant Signal Behav. 2012;7:990-3 pubmed publisher
..Recently, we showed that the Arabidopsis photomorphogenic repressor COP10 controls specific cell-lineage and cell-signaling developmental mechanisms in stomatal lineages...