Gene Symbol: FUS12
Description: proteasome family protein
Alias: ATCSN2, CONSTITUTIVE PHOTOMORPHOGENIC 12, COP12, CSN2, FUSCA 12, T20P8.4, T20P8_4, proteasome family protein
Species: thale cress
Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al
. Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell. 2003;15:719-31 pubmed
..Here, we report the cloning and characterization of AtCSN2, the last uncharacterized CSN subunit from Arabidopsis...
Schwechheimer C, Serino G, Callis J, Crosby W, Lyapina S, Deshaies R, et al
. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science. 2001;292:1379-82 pubmed
..Thus, the COP9 signalosome may play an important role in mediating E3 ubiquitin ligase-mediated responses. ..
Karniol B, Chamovitz D. The COP9 signalosome: from light signaling to general developmental regulation and back. Curr Opin Plant Biol. 2000;3:387-93 pubmed
..The COP9 complex is essential for animal development. The COP9 signalosome may have both an evolutionary and a physical relationship with both the regulatory lid of the proteasome and eIF3. ..
Wang X, Kang D, Feng S, Serino G, Schwechheimer C, Wei N. CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Mol Biol Cell. 2002;13:646-55 pubmed
..We conclude that CSN1 N-terminal domain is not required for the Rub1/Nedd8 deconjugation activity of cullins, but contributes to a significant aspect of CSN functions that are essential for plant development. ..
Gusmaroli G, Feng S, Deng X. The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. Plant Cell. 2004;16:2984-3001 pubmed
..The initial characterization of CSN5A and CSN5B insertion mutants further supports these findings and provides genetic evidence on their unequal role in plant development. ..
Nakasone A, Fujiwara M, Fukao Y, Biswas K, Rahman A, Kawai Yamada M, et al
. SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis. Plant Physiol. 2012;160:93-105 pubmed publisher
..Our findings suggest that SMAP1 is involved in the auxin response and possibly in other cullin-RING ubiquitin ligase-regulated signaling processes via its interaction with components associated with RELATED TO UBIQUITIN modification. ..
Deng X, Dubiel W, Wei N, Hofmann K, Mundt K, Colicelli J, et al
. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Trends Genet. 2000;16:202-3 pubmed
Gusmaroli G, Figueroa P, Serino G, Deng X. Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases. Plant Cell. 2007;19:564-81 pubmed
..This study thus completes the genetic analysis of all CSN subunits and confirms the structural interdependence between PCI and MPN subunits in functional CSN complex formation. ..