Gene Symbol: FTA
Description: farnesyltransferase A
Alias: ATFTA, FARNESYLTRANSFERASE A, FARNESYLTRANSFERASE SUBUNIT A, PFT/PGGT-IALPHA, PLP, PLURIPETALA, farnesyltransferase A, farnesyltransferase A
Species: thale cress
Caldelari D, Sternberg H, Rodríguez Concepción M, Gruissem W, Yalovsky S. Efficient prenylation by a plant geranylgeranyltransferase-I requires a functional CaaL box motif and a proximal polybasic domain. Plant Physiol. 2001;126:1416-29 pubmed
..yeast (Saccharomyces cerevisiae) two-hybrid screen, using the tomato (Lycopersicon esculentum) FTase alpha-subunit (FTA) as bait. Sequence and structure analysis revealed that the core active site of GGT-I and FTase are very similar...
Running M, Lavy M, Sternberg H, Galichet A, Gruissem W, Hake S, et al
. Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases. Proc Natl Acad Sci U S A. 2004;101:7815-20 pubmed
..We identified pluripetala (plp) mutants based on their dramatically larger meristems and increased floral organ number...
Wang Y, Ying J, Kuzma M, Chalifoux M, Sample A, McArthur C, et al
. Molecular tailoring of farnesylation for plant drought tolerance and yield protection. Plant J. 2005;43:413-24 pubmed
..Using protein farnesyltransferase as an effective target, these results represent a successful demonstration of engineered drought tolerance and yield protection in a crop plant under laboratory and field conditions. ..
Zeng Q, Wang X, Running M. Dual lipid modification of Arabidopsis Ggamma-subunits is required for efficient plasma membrane targeting. Plant Physiol. 2007;143:1119-31 pubmed
..Our data show the large degree to which PFT and PGGT-I can compensate for each other in plants and suggest that differential lipid modification plays an important regulatory role in plant protein localization. ..
Sorek N, Gutman O, Bar E, Abu Abied M, Feng X, Running M, et al
. Differential effects of prenylation and s-acylation on type I and II ROPS membrane interaction and function. Plant Physiol. 2011;155:706-20 pubmed publisher
..Phenotypic analysis of the CaaX prenylation-deficient pluripetala mutant epidermal cells revealed that type I ROPs affect cell structure primarily on the adaxial side, while ..
Bracha Drori K, Shichrur K, Katz A, Oliva M, Angelovici R, Yalovsky S, et al
. Detection of protein-protein interactions in plants using bimolecular fluorescence complementation. Plant J. 2004;40:419-27 pubmed
..In addition, protein interactions were confirmed by immunoprecipitations. These results demonstrate that plant BiFC is a simple, reliable and relatively fast method for determining protein-protein interactions in plants. ..
Andrews M, Huizinga D, Crowell D. The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypes. BMC Plant Biol. 2010;10:118 pubmed publisher
..Moreover, our results indicate that PFT and PGGT1 substrate specificities are primarily due to differences in catalysis, rather than differences in substrate binding. ..