Gene Symbol: FRO4
Description: ferric reduction oxidase 4
Alias: ATFRO4, MZF18.14, MZF18_14, ferric reduction oxidase 4, ferric reduction oxidase 4
Species: thale cress
Schagerlöf U, Wilson G, Hebert H, Al Karadaghi S, Hägerhäll C. Transmembrane topology of FRO2, a ferric chelate reductase from Arabidopsis thaliana. Plant Mol Biol. 2006;62:215-21 pubmed
..This core is present in the entire flavocytochrome b family. The large water soluble domain of FRO2, which contains NADPH, FAD and oxidoreductase sequence motifs, was located on the inside of the membrane. ..
Wu H, Li L, Du J, Yuan Y, Cheng X, Ling H. Molecular and biochemical characterization of the Fe(III) chelate reductase gene family in Arabidopsis thaliana. Plant Cell Physiol. 2005;46:1505-14 pubmed
..An assay for ferric chelate reductase activity revealed that AtFRO2, AtFRO3, AtFRO4, AtFRO5, AtFRO7 and AtFRO8 conferred significantly increased iron reduction activity compared with the control ..
Vasconcelos M, Eckert H, Arahana V, Graef G, Grusak M, Clemente T. Molecular and phenotypic characterization of transgenic soybean expressing the Arabidopsis ferric chelate reductase gene, FRO2. Planta. 2006;224:1116-28 pubmed
..These results suggest that heterologous expression of an iron chelate reductase in soybean can provide a route to alleviate iron deficiency chlorosis. ..
Bernal M, Casero D, Singh V, Wilson G, Grande A, Yang H, et al
. Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4/FRO5 and the copper dependence of iron homeostasis in Arabidopsis. Plant Cell. 2012;24:738-61 pubmed publisher
..In response to Cu deficiency, FERRIC REDUCTASE OXIDASE5 (FRO5) and FRO4 transcript levels increased strongly, in an SPL7-dependent manner...