Gene Symbol: FRO2
Description: ferric reduction oxidase 2
Alias: ATFRO2, F22L4.12, F22L4_12, FERRIC CHELATE REDUCTASE DEFECTIVE 1, FERRIC REDUCTION OXIDASE 2, FRD1, ferric reduction oxidase 2, ferric reduction oxidase 2
Species: thale cress

Top Publications

  1. Einset J, Winge P, Bones A, Connolly E. The FRO2 ferric reductase is required for glycine betaine's effect on chilling tolerance in Arabidopsis roots. Physiol Plant. 2008;134:334-41 pubmed publisher
    ..This idea was confirmed by showing that the FRO2 null mutant frd1-1 failed to respond to GB in chilling assays either in relation to root growth recovery or inhibition of ROS ..
  2. Baxter I, Vitek O, Lahner B, Muthukumar B, Borghi M, Morrissey J, et al. The leaf ionome as a multivariable system to detect a plant's physiological status. Proc Natl Acad Sci U S A. 2008;105:12081-6 pubmed publisher
    ..mutants and natural accessions for this Fe response signature successfully identified the known Fe mutants frd1 and frd3...
  3. Chen W, Yang J, Qin C, Jin C, Mo J, Ye T, et al. Nitric oxide acts downstream of auxin to trigger root ferric-chelate reductase activity in response to iron deficiency in Arabidopsis. Plant Physiol. 2010;154:810-9 pubmed publisher
    ..of root FCR activity and the expression of the basic helix-loop-helix transcription factor (FIT) and the ferric reduction oxidase 2 (FRO2) genes...
  4. Robinson N, Procter C, Connolly E, Guerinot M. A ferric-chelate reductase for iron uptake from soils. Nature. 1999;397:694-7 pubmed
    ..Here we report the isolation of the FRO2 gene, which is expressed in iron-deficient roots of Arabidopsis...
  5. Yuan Y, Wu H, Wang N, Li J, Zhao W, Du J, et al. FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis. Cell Res. 2008;18:385-97 pubmed publisher
    ..of FIT/AtbHLH38 or FIT/AtbHLH39 in yeast cells activated GUS expression driven by ferric chelate reductase (FRO2) and ferrous transporter (IRT1) promoters...
  6. Segond D, Dellagi A, Lanquar V, Rigault M, Patrit O, Thomine S, et al. NRAMP genes function in Arabidopsis thaliana resistance to Erwinia chrysanthemi infection. Plant J. 2009;58:195-207 pubmed publisher
    ..roots from infected plants accumulated transcripts of AtNRAMP3 as well as the iron-deficiency markers IRT1 and FRO2. This finding suggests the existence of a shoot-to-root signal reminiscent of an iron-deficiency signal activated ..
  7. Sivitz A, Grinvalds C, Barberon M, Curie C, Vert G. Proteasome-mediated turnover of the transcriptional activator FIT is required for plant iron-deficiency responses. Plant J. 2011;66:1044-52 pubmed publisher
    ..In the model plant Arabidopsis thaliana, the ferric-chelate reductase FRO2 and the ferrous iron transporter IRT1 control iron entry from the soil into the root epidermis...
  8. Sagi M, Fluhr R. Production of reactive oxygen species by plant NADPH oxidases. Plant Physiol. 2006;141:336-40 pubmed
  9. Fourcroy P, Tissot N, Gaymard F, Briat J, Dubos C. Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System. Mol Plant. 2016;9:485-488 pubmed publisher

More Information


  1. Durrett T, Connolly E, Rogers E. Arabidopsis cpFtsY mutants exhibit pleiotropic defects including an inability to increase iron deficiency-inducible root Fe(III) chelate reductase activity. Plant J. 2006;47:467-79 pubmed
    ..In Arabidopsis, the enzyme responsible for this reductase activity in the roots is encoded by FRO2. Two Arabidopsis mutants, frd4-1 and frd4-2, were isolated in a screen for plants that do not induce Fe(III) ..
  2. Maurer F, Muller S, Bauer P. Suppression of Fe deficiency gene expression by jasmonate. Plant Physiol Biochem. 2011;49:530-6 pubmed publisher
    ..Induction of IRT1 and FRO2 gene expression can be used to monitor the Fe deficiency status of plant roots...
  3. Wu H, Li L, Du J, Yuan Y, Cheng X, Ling H. Molecular and biochemical characterization of the Fe(III) chelate reductase gene family in Arabidopsis thaliana. Plant Cell Physiol. 2005;46:1505-14 pubmed
    ..are eight genes classified into the iron chelate reductase gene family (AtFROs) based on sequence homology with AtFRO2 (a ferric chelate reductase in Arabidopsis)...
  4. Vert G, Barberon M, Zelazny E, Séguéla M, Briat J, Curie C. Arabidopsis IRT2 cooperates with the high-affinity iron uptake system to maintain iron homeostasis in root epidermal cells. Planta. 2009;229:1171-9 pubmed publisher
    ..Consequently, plants carefully regulate their iron uptake, dependent on the FRO2 ferric reductase and the IRT1 transporter, to control its homeostasis...