FRIGIDA

Summary

Gene Symbol: FRIGIDA
Description: FRIGIDA-like protein
Alias: F6N23.25, F6N23_25, FLA, FLOWERING LOCUS A, FRIGIDA, REDUCED STEM BRANCHING 7, RSB7, FRIGIDA-like protein
Species: thale cress

Top Publications

  1. Lee I, Bleecker A, Amasino R. Analysis of naturally occurring late flowering in Arabidopsis thaliana. Mol Gen Genet. 1993;237:171-6 pubmed
    ..This gene, which we refer to as FLA, is located at one end of chromosome 4 between RFLP markers 506 and 3843 and is thus distinct from previously ..
  2. Scarcelli N, Kover P. Standing genetic variation in FRIGIDA mediates experimental evolution of flowering time in Arabidopsis. Mol Ecol. 2009;18:2039-49 pubmed publisher
    ..in two candidate flowering time genes, in response to selection for early flowering in Arabidopsis thaliana: FRIGIDA (FRI) and FLOWERING LOCUS C (FLC)...
  3. Shindo C, Aranzana M, Lister C, Baxter C, Nicholls C, Nordborg M, et al. Role of FRIGIDA and FLOWERING LOCUS C in determining variation in flowering time of Arabidopsis. Plant Physiol. 2005;138:1163-73 pubmed
    ..We explored the contribution to this variation from the two genes FRIGIDA (FRI) and FLOWERING LOCUS C (FLC), previously shown to be important determinants in natural variation of ..
  4. Geraldo N, Bäurle I, Kidou S, Hu X, Dean C. FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex. Plant Physiol. 2009;150:1611-8 pubmed publisher
    A major determinant of flowering time in natural Arabidopsis (Arabidopsis thaliana) variants is FRIGIDA (FRI)...
  5. Méndez Vigo B, Pico F, Ramiro M, Martinez Zapater J, Alonso Blanco C. Altitudinal and climatic adaptation is mediated by flowering traits and FRI, FLC, and PHYC genes in Arabidopsis. Plant Physiol. 2011;157:1942-55 pubmed publisher
    ..In addition, we used an association analysis approach with four candidate genes, FRIGIDA (FRI), FLOWERING LOCUS C (FLC), PHYTOCHROME C (PHYC), and CRYPTOCHROME2, to decipher the genetic bases of this ..
  6. Kurbidaeva A, Zaretskaia M, Soltabaeva A, Novokreshchenova M, Kupriianova E, Fedorenko O, et al. [Genetic base of Arabidopsis thaliana (L.) Heynh: fitness of plants for extreme conditions in northern margins of species range]. Genetika. 2013;49:943-52 pubmed
    ..The lack of significant differences between northern populations, as well as the ecotypes Dijon-M (Europe) and Cvi-0 (Cape Verde Islands), indicates that this pathway is not crucial for fitness to the northern environment. ..
  7. Sánchez Bermejo E, Balasubramanian S. Natural variation involving deletion alleles of FRIGIDA modulate temperature-sensitive flowering responses in Arabidopsis thaliana. Plant Cell Environ. 2016;39:1353-65 pubmed publisher
    ..identified several QTLs for thermal response including three major effect loci encompassing candidate genes FRIGIDA (FRI), FLOWERING LOCUS C (FLC) and FLOWERING LOCUS T (FT). We confirm and validate these QTLs...
  8. Bezerra I, Michaels S, Schomburg F, Amasino R. Lesions in the mRNA cap-binding gene ABA HYPERSENSITIVE 1 suppress FRIGIDA-mediated delayed flowering in Arabidopsis. Plant J. 2004;40:112-9 pubmed
    Recessive mutations that suppress the late-flowering phenotype conferred by FRIGIDA (FRI) and FLOWERING LOCUS C (FLC) and which also result in serrated leaf morphology were identified in T-DNA and fast-neutron mutant populations...
  9. Choi K, Kim J, Hwang H, Kim S, Park C, Kim S, et al. The FRIGIDA complex activates transcription of FLC, a strong flowering repressor in Arabidopsis, by recruiting chromatin modification factors. Plant Cell. 2011;23:289-303 pubmed publisher
    ..b>FRIGIDA (FRI) activates the transcription of FLC, but the molecular mechanism remains elusive...

More Information

Publications24

  1. Doyle M, Amasino R. A single amino acid change in the enhancer of zeste ortholog CURLY LEAF results in vernalization-independent, rapid flowering in Arabidopsis. Plant Physiol. 2009;151:1688-97 pubmed publisher
    ..also identified a marked difference in H3K27me3 levels at FLC between plants that contain and those that lack the FRIGIDA (FRI) gene...
  2. Schmalenbach I, Zhang L, Ryngajllo M, Jiménez Gómez J. Functional analysis of the Landsberg erecta allele of FRIGIDA. BMC Plant Biol. 2014;14:218 pubmed publisher
    ..natural variation in flowering time in Arabidopsis thaliana can be attributed to allelic variation at the gene FRIGIDA (FRI, AT4G00650), which activates expression of the floral repressor FLOWERING LOCUS C (FLC, AT5G10140)...
  3. Schmitz R, Hong L, Michaels S, Amasino R. FRIGIDA-ESSENTIAL 1 interacts genetically with FRIGIDA and FRIGIDA-LIKE 1 to promote the winter-annual habit of Arabidopsis thaliana. Development. 2005;132:5471-8 pubmed
    ..variation have revealed that the winter-annual habit of many accessions of Arabidopsis is conferred by two genes, FRIGIDA (FRI) and FLOWERING LOCUS C (FLC), whose activities impose a vernalization requirement...
  4. Risk J, Laurie R, Macknight R, Day C. FRIGIDA and related proteins have a conserved central domain and family specific N- and C- terminal regions that are functionally important. Plant Mol Biol. 2010;73:493-505 pubmed publisher
    ..Typically, winter annual accessions have functional FRIGIDA (FRI) and FRIGIDA-LIKE 1 (FRL1) proteins that promote high expression of FLOWERING LOCUS C (FLC), which prevents ..
  5. Chen Q, Zheng Y, Luo L, Yang Y, Hu X, Kong X. Functional FRIGIDA allele enhances drought tolerance by regulating the P5CS1 pathway in Arabidopsis thaliana. Biochem Biophys Res Commun. 2018;495:1102-1107 pubmed publisher
    ..In Arabidopsis, a major determinant of natural variation in flowering time is FRIGIDA (FRI)...
  6. Hyun K, Oh J, Park J, Noh Y, Song J. Structural Analysis of FRIGIDA Flowering-Time Regulator. Mol Plant. 2016;9:618-20 pubmed publisher
  7. Andersson C, Helliwell C, Bagnall D, Hughes T, Finnegan E, Peacock W, et al. The FLX gene of Arabidopsis is required for FRI-dependent activation of FLC expression. Plant Cell Physiol. 2008;49:191-200 pubmed
    ..FLX encodes a protein of unknown function with putative leucine zipper domains. FLX is required for FRIGIDA (FRI)-mediated activation of FLC but not for activation of FLC in autonomous pathway mutants...
  8. Lovell J, Juenger T, Michaels S, Lasky J, Platt A, Richards J, et al. Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. Proc Biol Sci. 2013;280:20131043 pubmed publisher
    ..Here, we present evidence that the Arabidopsis thaliana gene FRI (FRIGIDA) exhibits 'adaptive' pleiotropy, producing trait correlations along an axis that results in two adaptive ..
  9. Kim S, Choi K, Park C, Hwang H, Lee I. SUPPRESSOR OF FRIGIDA4, encoding a C2H2-Type zinc finger protein, represses flowering by transcriptional activation of Arabidopsis FLOWERING LOCUS C. Plant Cell. 2006;18:2985-98 pubmed
    ..The expression of FLC is increased by FRIGIDA (FRI) but decreased by vernalization, a long period of cold exposure that accelerates flowering...
  10. Lee H, Suh S, Park E, Cho E, Ahn J, Kim S, et al. The AGAMOUS-LIKE 20 MADS domain protein integrates floral inductive pathways in Arabidopsis. Genes Dev. 2000;14:2366-76 pubmed
    The very late-flowering behavior of Arabidopsis winter-annual ecotypes is conferred mainly by two genes, FRIGIDA (FRI) and FLOWERING LOCUS C (FLC)...
  11. Wang J, Tian L, Lee H, Chen Z. Nonadditive regulation of FRI and FLC loci mediates flowering-time variation in Arabidopsis allopolyploids. Genetics. 2006;173:965-74 pubmed
    ..Natural variation of flowering time is largely controlled by two epistatically acting loci, namely FRIGIDA (FRI) and FLOWERING LOCUS C (FLC). FRI upregulates FLC expression that represses flowering in Arabidopsis...
  12. Hu X, Kong X, Wang C, Ma L, Zhao J, Wei J, et al. Proteasome-mediated degradation of FRIGIDA modulates flowering time in Arabidopsis during vernalization. Plant Cell. 2014;26:4763-81 pubmed publisher
    ..of Arabidopsis thaliana require either exposure to cold stress or vernalization to initiate flowering via FRIGIDA (FRI)...
  13. Doyle M, Bizzell C, Keller M, Michaels S, Song J, Noh Y, et al. HUA2 is required for the expression of floral repressors in Arabidopsis thaliana. Plant J. 2005;41:376-85 pubmed
    ..hua2 mutations partially suppress late flowering in FRIGIDA (FRI )-containing lines, autonomous pathway mutants, and a photoperiod pathway mutant...
  14. Scarcelli N, Cheverud J, Schaal B, Kover P. Antagonistic pleiotropic effects reduce the potential adaptive value of the FRIGIDA locus. Proc Natl Acad Sci U S A. 2007;104:16986-91 pubmed
    ..importance of pleiotropy and epistasis in determining the adaptive value of a candidate gene using the gene FRI (FRIGIDA), which is thought to be the major gene controlling flowering time variation in Arabidopsis thaliana...
  15. Ding L, Kim S, Michaels S. FLOWERING LOCUS C EXPRESSOR family proteins regulate FLOWERING LOCUS C expression in both winter-annual and rapid-cycling Arabidopsis. Plant Physiol. 2013;163:243-52 pubmed publisher
    ..In these winter-annual strains, flowering prior to winter is blocked by the synergistic interaction of FRIGIDA (FRI) and FLOWERING LOCUS C (FLC)...