FLU

Summary

Gene Symbol: FLU
Description: Tetratricopeptide repeat (TPR)-like superfamily protein
Alias: FLUORESCENT IN BLUE LIGHT, Tetratricopeptide repeat (TPR)-like superfamily protein
Species: thale cress

Top Publications

  1. Laloi C, Przybyla D, Apel K. A genetic approach towards elucidating the biological activity of different reactive oxygen species in Arabidopsis thaliana. J Exp Bot. 2006;57:1719-24 pubmed
    ..The conditional flu mutant of Arabidopsis has been used to determine the biological role of singlet oxygen...
  2. Goslings D, Meskauskiene R, Kim C, Lee K, Nater M, Apel K. Concurrent interactions of heme and FLU with Glu tRNA reductase (HEMA1), the target of metabolic feedback inhibition of tetrapyrrole biosynthesis, in dark- and light-grown Arabidopsis plants. Plant J. 2004;40:957-67 pubmed
    ..Recently, another negative regulator of tetrapyrrole biosynthesis has been discovered, the FLU protein...
  3. Przybyla D, Gobel C, Imboden A, Hamberg M, Feussner I, Apel K. Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana. Plant J. 2008;54:236-48 pubmed publisher
    The conditional flu mutant of Arabidopsis accumulates excess amounts of protochlorophyllide within plastid membranes in the dark and generates singlet oxygen upon light exposure...
  4. Fang Y, Zhao S, Zhang F, Zhao A, Zhang W, Zhang M, et al. The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein. Sci Rep. 2016;6:19756 pubmed publisher
    ..By binding to the thylakoid membrane protein FLUORESCENT (FLU) or the soluble stromal GluTR-binding protein (GBP), the activity of GluTR is down- or up-regulated...
  5. Meskauskiene R, Nater M, Goslings D, Kessler F, op den Camp R, Apel K. FLU: a negative regulator of chlorophyll biosynthesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2001;98:12826-31 pubmed
    ..In Arabidopsis thaliana, we have found a negative regulator of tetrapyrrole biosynthesis, FLU, which operates independently of heme and seems to selectively affect only the Mg(2+) branch of tetrapyrrole ..
  6. Lee K, Kim C, Landgraf F, Apel K. EXECUTER1- and EXECUTER2-dependent transfer of stress-related signals from the plastid to the nucleus of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2007;104:10270-5 pubmed
    ..after the release of singlet oxygen ((1)O2), drastic changes in nuclear gene expression occur in the conditional flu mutant of Arabidopsis that reveal a rapid transfer of signals from the plastid to the nucleus...
  7. Zhang M, Zhang F, Fang Y, Chen X, Chen Y, Zhang W, et al. The Non-canonical Tetratricopeptide Repeat (TPR) Domain of Fluorescent (FLU) Mediates Complex Formation with Glutamyl-tRNA Reductase. J Biol Chem. 2015;290:17559-65 pubmed publisher
    The tetratricopeptide repeat (TPR)-containing protein FLU is a negative regulator of chlorophyll biosynthesis in plants...
  8. Kauss D, Bischof S, Steiner S, Apel K, Meskauskiene R. FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg(++)-branch of this pathway. FEBS Lett. 2012;586:211-6 pubmed publisher
    ..Two effectors of feedback inhibition have been identified, heme and the FLU protein. Inhibition by heme implicates the Fe-branch via regulation of the initial step of tetrapyrrole synthesis...