Gene Symbol: FLD
Description: protein FLOWERING locus D-like protein
Alias: FLOWERING LOCUS D, RSI1, Reduced Systemic immunity 1, protein FLOWERING locus D-like protein
Species: thale cress

Top Publications

  1. He Y, Michaels S, Amasino R. Regulation of flowering time by histone acetylation in Arabidopsis. Science. 2003;302:1751-4 pubmed
    ..Here, we report that FLOWERING LOCUS D (FLD), one of six genes in the autonomous pathway, encodes a plant homolog of a protein found in histone ..
  2. Liu F, Quesada V, Crevillen P, Bäurle I, Swiezewski S, Dean C. The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC. Mol Cell. 2007;28:398-407 pubmed
    ..Here, we show that FCA requires FLOWERING LOCUS D (FLD), a homolog of the human lysine-specific demethylase 1 (LSD1) for FLC downregulation...
  3. Jin J, Jin Y, Lee J, Miura K, Yoo C, Kim W, et al. The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure. Plant J. 2008;53:530-40 pubmed
    ..Interestingly, increased FLC expression and late flowering of an autonomous pathway mutant, flowering locus d (fld), was not suppressed by siz1, suggesting that SIZ1 promotes FLC expression by repressing FLD...
  4. Singh V, Roy S, Giri M, Chaturvedi R, Chowdhury Z, Shah J, et al. Arabidopsis thaliana FLOWERING LOCUS D is required for systemic acquired resistance. Mol Plant Microbe Interact. 2013;26:1079-88 pubmed publisher
    ..Here, we show that, in Arabidopsis thaliana, the FLOWERING LOCUS D (FLD) is required for responding to the SAR signals leading to the systemic accumulation of SA and ..
  5. Yu C, Liu X, Luo M, Chen C, Lin X, Tian G, et al. HISTONE DEACETYLASE6 interacts with FLOWERING LOCUS D and regulates flowering in Arabidopsis. Plant Physiol. 2011;156:173-84 pubmed publisher
    ..and coimmunoprecipitation assays revealed the protein-protein interaction between HDA6 and the histone demethylase FLD. It was found that the SWIRM domain in the amino-terminal region of FLD and the carboxyl-terminal region of HDA6 ..
  6. Luo M, Tai R, Yu C, Yang S, Chen C, Lin W, et al. Regulation of flowering time by the histone deacetylase HDA5 in Arabidopsis. Plant J. 2015;82:925-36 pubmed publisher
    ..fluorescence complementation assays and co-immunoprecipitation assays showed that HDA5 interacts with FVE, FLD and HDA6, indicating that these proteins are present in a protein complex involved in the regulation of flowering ..
  7. Sadiq I, Keren I, Citovsky V. Plant homologs of mammalian MBT-domain protein-regulated KDM1 histone lysine demethylases do not interact with plant Tudor/PWWP/MBT-domain proteins. Biochem Biophys Res Commun. 2016;470:913-6 pubmed publisher
    ..organisms, from animals to plants, we examined whether the KDM1-type histone lysine demethylases KDM1C and FLD of Arabidopsis interact with the Arabidopsis Tudor/PWWP/MBT-domain SFMBT1-like proteins SL1, SL2, SL3, and SL4...
  8. Zhang Y, Li B, Xu Y, Li H, Li S, Zhang D, et al. The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis. Plant Cell. 2013;25:2504-21 pubmed publisher
    ..BZR1), the conformation of which is altered by a cyclophilin (CYP20-2), binds cis-elements in the FLOWERING LOCUS D (FLD) promoter to regulate flowering. Both bzr1-1D and fld-4 showed delayed flowering...
  9. Singh V, Roy S, Singh D, Nandi A. Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes. J Biosci. 2014;39:119-26 pubmed
    ..Recently we showed that flowering locus D (FLD) gene of Arabidopsis thaliana is required in the distal tissue to activate SAR...

More Information


  1. Doyle M, Amasino R. A single amino acid change in the enhancer of zeste ortholog CURLY LEAF results in vernalization-independent, rapid flowering in Arabidopsis. Plant Physiol. 2009;151:1688-97 pubmed publisher
    ..Furthermore, FRI appears to affect CLF occupancy at FLC; thus, our work provides insight into the molecular role that FRI plays in delaying the onset of flowering. ..