Gene Symbol: FCA
Description: flowering time control protein FCA
Species: thale cress

Top Publications

  1. Risk J, Macknight R, Day C. FCA does not bind abscisic acid. Nature. 2008;456:E5-6 pubmed publisher
    The RNA-binding protein FCA promotes flowering in Arabidopsis. Razem et al. reported that FCA is also a receptor for the phytohormone abscisic acid (ABA)...
  2. Macknight R, Bancroft I, Page T, Lister C, Schmidt R, Love K, et al. FCA, a gene controlling flowering time in Arabidopsis, encodes a protein containing RNA-binding domains. Cell. 1997;89:737-45 pubmed
    A strong promoter of the transition to flowering in Arabidopsis is encoded by FCA. FCA has been cloned and shown to encode a protein containing two RNA-binding domains and a WW protein interaction domain...
  3. Reeves P, Coupland G. Analysis of flowering time control in Arabidopsis by comparison of double and triple mutants. Plant Physiol. 2001;126:1085-91 pubmed
    ..These pathways are represented by the genes CO, FCA, and GA1, which act in the long-day, autonomous, and gibberellin pathways, respectively...
  4. Jung J, Seo P, Ahn J, Park C. Arabidopsis RNA-binding protein FCA regulates microRNA172 processing in thermosensory flowering. J Biol Chem. 2012;287:16007-16 pubmed publisher
    ..Here, we show that Arabidopsis RNA-binding protein FCA promotes the processing of primary microRNA172 transcripts (pri-miR172) in response to changes in ambient ..
  5. Marquardt S, Boss P, Hadfield J, Dean C. Additional targets of the Arabidopsis autonomous pathway members, FCA and FY. J Exp Bot. 2006;57:3379-86 pubmed
    ..One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK...
  6. Lee H, Ha J, Park C. An FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants. BMB Rep. 2017;50:343-344 pubmed
    ..In our recent study, we demonstrated that the RNA-binding protein, FCA, is critical for sustaining chlorophyll biosynthesis during early seedling development, which is a prerequisite for ..
  7. Sonmez C, Bäurle I, Magusin A, Dreos R, Laubinger S, Weigel D, et al. RNA 3' processing functions of Arabidopsis FCA and FPA limit intergenic transcription. Proc Natl Acad Sci U S A. 2011;108:8508-13 pubmed publisher
    The RNA-binding proteins FCA and FPA were identified based on their repression of the flowering time regulator FLC but have since been shown to have widespread roles in the Arabidopsis thaliana genome...
  8. Soppe W, Bentsink L, Koornneef M. The early-flowering mutant efs is involved in the autonomous promotion pathway of Arabidopsis thaliana. Development. 1999;126:4763-70 pubmed
    ..Double mutant analysis with several late-flowering mutants from the autonomous promotion (fca and fve) and the photoperiod promotion (co, fwa and gi) pathways of flowering showed that efs reduces the flowering ..
  9. Lee H, Jung J, Cortés Llorca L, Kim S, Lee S, Baldwin I, et al. FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis. Nat Commun. 2014;5:5473 pubmed publisher
    ..Here we demonstrate that the RNA-binding protein FCA attenuates PIF4 activity by inducing its dissociation from the YUC8 promoter at high temperature...

More Information


  1. Sarnowski T, Rios G, Jasik J, Swiezewski S, Kaczanowski S, Li Y, et al. SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development. Plant Cell. 2005;17:2454-72 pubmed
    ..and ATSWI3B form homodimers and heterodimers and interact with BSH/SNF5, ATSWI3C, and the flowering regulator FCA, ATSWI3D can only bind ATSWI3B in yeast two-hybrid assays...
  2. Henderson I, Liu F, Drea S, Simpson G, Dean C. An allelic series reveals essential roles for FY in plant development in addition to flowering-time control. Development. 2005;132:3597-607 pubmed publisher
    ..Within this pathway FCA is a plant-specific, nuclear RNA-binding protein, which interacts with FY, a highly conserved eukaryotic ..
  3. Simpson G, Dijkwel P, Quesada V, Henderson I, Dean C. FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition. Cell. 2003;113:777-87 pubmed
    The nuclear RNA binding protein, FCA, promotes Arabidopsis reproductive development. FCA contains a WW protein interaction domain that is essential for FCA function. We have identified FY as a protein partner for this domain...
  4. Jang Y, Lee J, Kim J. Abscisic acid does not disrupt either the Arabidopsis FCA-FY interaction or its rice counterpart in vitro. Plant Cell Physiol. 2008;49:1898-901 pubmed publisher
    We examined the effect of (+)-ABA on the in vitro interaction of rice FCA and FY homologs, OsFCA and OsFY. From this analysis, we found no disruption of the OsFCA-OsFY complexes by ABA treatment...
  5. Liu F, Quesada V, Crevillen P, Bäurle I, Swiezewski S, Dean C. The Arabidopsis RNA-binding protein FCA requires a lysine-specific demethylase 1 homolog to downregulate FLC. Mol Cell. 2007;28:398-407 pubmed
    A repressor of the transition to flowering in Arabidopsis is the MADS box protein FLOWERING LOCUS C (FLC). FCA, an RNA-binding protein, and FY, a homolog of the yeast RNA 3' processing factor Pfs2p, downregulate FLC expression and ..
  6. Simpson G, Laurie R, Dijkwel P, Quesada V, Stockwell P, Dean C, et al. Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA. Plant Cell. 2010;22:3764-77 pubmed publisher
    The RNA binding protein FCA regulates the floral transition and is required for silencing RNAs corresponding to specific noncoding sequences in the Arabidopsis thaliana genome...
  7. Lee S, Lee H, Jung J, Park C. The Arabidopsis thaliana RNA-binding protein FCA regulates thermotolerance by modulating the detoxification of reactive oxygen species. New Phytol. 2015;205:555-69 pubmed publisher
    ..Here, we demonstrate that the RNA-binding protein FCA, a key component of flowering pathways in Arabidopsis thaliana, is required for the acquisition of thermotolerance...
  8. Bäurle I, Smith L, Baulcombe D, Dean C. Widespread role for the flowering-time regulators FCA and FPA in RNA-mediated chromatin silencing. Science. 2007;318:109-12 pubmed
    The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range of loci in the genome...
  9. Sarnowski T, Swiezewski S, Pawlikowska K, Kaczanowski S, Jerzmanowski A. AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf chromatin remodeling complex, interacts with FCA, a regulator of flowering time. Nucleic Acids Res. 2002;30:3412-21 pubmed
    ..using recombinant protein, confirmed by direct yeast two-hybrid analyses, indicate that AtSWI3B interacts with FCA, a regulator of flowering time in Arabidopsis...
  10. Sugliani M, Brambilla V, Clerkx E, Koornneef M, Soppe W. The conserved splicing factor SUA controls alternative splicing of the developmental regulator ABI3 in Arabidopsis. Plant Cell. 2010;22:1936-46 pubmed publisher
    ..We detected two ABI3 transcripts, ABI3-alpha and ABI3-beta, which encode full-length and truncated proteins, respectively...