Gene Symbol: FAS1
Description: chromatin assembly factor-1 (FASCIATA1) (FAS1)
Species: thale cress

Top Publications

  1. Kirik A, Pecinka A, Wendeler E, Reiss B. The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants. Plant Cell. 2006;18:2431-42 pubmed
    ..Here, we show that fasciata1-4 (fas1-4), a new allele of the Arabidopsis fas1 mutant defective in the p150 subunit of CAF-1, has a severe developmental ..
  2. Ono T, Kaya H, Takeda S, Abe M, Ogawa Y, Kato M, et al. Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis. Genes Cells. 2006;11:153-62 pubmed
    ..Furthermore, TGS of the silent beta-glucuronidase (GUS) transgene was also de-repressed randomly in fas. We conclude that CAF-1 ensures the stable inheritance of epigenetic states through growth and development in Arabidopsis. ..
  3. Schonrock N, Exner V, Probst A, Gruissem W, Hennig L. Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana. J Biol Chem. 2006;281:9560-8 pubmed
  4. Endo M, Ishikawa Y, Osakabe K, Nakayama S, Kaya H, Araki T, et al. Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants. EMBO J. 2006;25:5579-90 pubmed
    ..In Arabidopsis thaliana, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively...
  5. Chen Z, Tan J, Ingouff M, Sundaresan V, Berger F. Chromatin assembly factor 1 regulates the cell cycle but not cell fate during male gametogenesis in Arabidopsis thaliana. Development. 2008;135:65-73 pubmed
    ..The single sperm is functional and fertilizes indiscriminately either female gamete. Our results thus suggest that pollen cell fate is independent from cell cycle regulation. ..
  6. Exner V, Gruissem W, Hennig L. Control of trichome branching by chromatin assembly factor-1. BMC Plant Biol. 2008;8:54 pubmed publisher
    ..Finally, CAF-1 is also needed for the high degree of endoreduplication in kaktus mutants and thus for the realization of kaktus' extreme overbranching phenotype. ..
  7. Exner V, Taranto P, Schonrock N, Gruissem W, Hennig L. Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development. Development. 2006;133:4163-72 pubmed
    ..These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps ..
  8. Ramirez Parra E, Gutierrez C. E2F regulates FASCIATA1, a chromatin assembly gene whose loss switches on the endocycle and activates gene expression by changing the epigenetic status. Plant Physiol. 2007;144:105-20 pubmed
    ..Here, we show that the FASCIATA1 (FAS1) gene, which encodes the CAF-1 large subunit, is a target of E2F transcription factors...
  9. Kaya H, Shibahara K, Taoka K, Iwabuchi M, Stillman B, Araki T. FASCIATA genes for chromatin assembly factor-1 in arabidopsis maintain the cellular organization of apical meristems. Cell. 2001;104:131-42 pubmed
    ..Arabidopsis FASCIATA1 (FAS1) and FAS2 genes maintain the cellular and functional organization of both SAM and RAM, and FAS gene products are ..

More Information


  1. Li H, Luan S. The cyclophilin AtCYP71 interacts with CAF-1 and LHP1 and functions in multiple chromatin remodeling processes. Mol Plant. 2011;4:748-58 pubmed publisher
    ..Here, we show that AtCYP71 physically interacts with FAS1 and LHP1, respectively, to modulate their distribution on chromatin...
  2. Jaške K, Mokros P, Mozgová I, Fojtova M, Fajkus J. A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana. Chromosoma. 2013;122:285-93 pubmed publisher
    ..We conclude that in addition to possible impairment of telomerase action, a further mechanism contributes to telomere shortening in fas mutants. ..
  3. Duc C, Benoit M, Le Goff S, Simon L, Poulet A, Cotterell S, et al. The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants. Plant J. 2015;81:707-22 pubmed publisher
    ..Our results suggest that HIRA partially rescues impaired histone deposition in fas mutants to preserve nucleosome occupancy, implying plasticity in histone variant interaction and deposition. ..
  4. Barrero J, González Bayón R, del Pozo J, Ponce M, Micol J. INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana. Plant Cell. 2007;19:2822-38 pubmed
    ..Quantitative RT-PCR analyses indicated that a number of regulatory genes were derepressed in the icu2-1 mutant, including genes associated with flowering time, floral meristem, and floral organ identity. ..
  5. Mozgová I, Mokros P, Fajkus J. Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana. Plant Cell. 2010;22:2768-80 pubmed publisher
    ..It is composed of CAC 1-3 in yeast; p155, p60, and p48 in humans; and FASCIATA1 (FAS1), FAS2, and MULTICOPY SUPPRESSOR OF IRA1 in Arabidopsis thaliana...
  6. Hisanaga T, Ferjani A, Horiguchi G, Ishikawa N, Fujikura U, Kubo M, et al. The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development. Plant Physiol. 2013;162:831-41 pubmed publisher
    ..The fugu2 mutants in Arabidopsis (Arabidopsis thaliana) exhibit typical compensation phenotypes...