ETR1

Summary

Gene Symbol: ETR1
Description: Signal transduction histidine kinase, hybrid-type, ethylene sensor
Alias: AtETR1, EIN1, ETHYLENE INSENSITIVE 1, ETHYLENE RESPONSE, ETHYLENE RESPONSE 1, ETR, HISTIDINE KINASE ETR1, T27F4.9, T27F4_9, Signal transduction histidine kinase, hybrid-type, ethylene sensor
Species: thale cress

Top Publications

  1. Resnick J, Wen C, Shockey J, Chang C. REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis. Proc Natl Acad Sci U S A. 2006;103:7917-22 pubmed
    ..rte1 loss-of-function mutants have an enhanced ethylene response that closely resembles the etr1 null phenotype...
  2. Gamble R, Qu X, Schaller G. Mutational analysis of the ethylene receptor ETR1. Role of the histidine kinase domain in dominant ethylene insensitivity. Plant Physiol. 2002;128:1428-38 pubmed
    The ethylene receptor family of Arabidopsis consists of five members, one of these being ETR1. The N-terminal half of ETR1 contains a hydrophobic domain responsible for ethylene binding and membrane localization...
  3. Xie F, Liu Q, Wen C. Receptor signal output mediated by the ETR1 N terminus is primarily subfamily I receptor dependent. Plant Physiol. 2006;142:492-508 pubmed
    b>etr1-1 is a dominant ethylene receptor gene in Arabidopsis (Arabidopsis thaliana) and confers ethylene insensitivity...
  4. Cho Y, Yoo S. ETHYLENE RESPONSE 1 histidine kinase activity of Arabidopsis promotes plant growth. Plant Physiol. 2007;143:612-6 pubmed
  5. Clark K, Larsen P, Wang X, Chang C. Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. Proc Natl Acad Sci U S A. 1998;95:5401-6 pubmed
    In Arabidopsis thaliana, signal transduction of the hormone ethylene involves at least two receptors, ETR1 and ERS, both of which are members of the two-component histidine protein kinase family that is prevalent in prokaryotes...
  6. Liu Q, Wen C. Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes. Plant Physiol. 2012;158:1193-207 pubmed publisher
    The ethylene response is negatively regulated by a family of five ethylene receptor genes in Arabidopsis (Arabidopsis thaliana)...
  7. Chen Y, Randlett M, Findell J, Schaller G. Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis. J Biol Chem. 2002;277:19861-6 pubmed
    The ethylene receptor ETR1 of Arabidopsis contains transmembrane domains responsible for ethylene binding and membrane localization...
  8. Qu X, Hall B, Gao Z, Schaller G. A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1. BMC Plant Biol. 2007;7:3 pubmed
    ..Single mutants show an ethylene response similar to wild type, although both mutants are slightly hypersensitive to ethylene...
  9. Chang C, Kwok S, Bleecker A, Meyerowitz E. Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science. 1993;262:539-44 pubmed
    ..Ethylene insensitivity is conferred by dominant mutations in the ETR1 gene early in the ethylene signal transduction pathway of Arabidopsis thaliana...
  10. Schaller G, Bleecker A. Ethylene-binding sites generated in yeast expressing the Arabidopsis ETR1 gene. Science. 1995;270:1809-11 pubmed
    Mutations in the ETR1 gene of Arabidopsis thaliana confer insensitivity to ethylene, which indicates a role for the gene product in ethylene signal transduction...

Detail Information

Publications68

  1. Resnick J, Wen C, Shockey J, Chang C. REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis. Proc Natl Acad Sci U S A. 2006;103:7917-22 pubmed
    ..rte1 loss-of-function mutants have an enhanced ethylene response that closely resembles the etr1 null phenotype...
  2. Gamble R, Qu X, Schaller G. Mutational analysis of the ethylene receptor ETR1. Role of the histidine kinase domain in dominant ethylene insensitivity. Plant Physiol. 2002;128:1428-38 pubmed
    The ethylene receptor family of Arabidopsis consists of five members, one of these being ETR1. The N-terminal half of ETR1 contains a hydrophobic domain responsible for ethylene binding and membrane localization...
  3. Xie F, Liu Q, Wen C. Receptor signal output mediated by the ETR1 N terminus is primarily subfamily I receptor dependent. Plant Physiol. 2006;142:492-508 pubmed
    b>etr1-1 is a dominant ethylene receptor gene in Arabidopsis (Arabidopsis thaliana) and confers ethylene insensitivity...
  4. Cho Y, Yoo S. ETHYLENE RESPONSE 1 histidine kinase activity of Arabidopsis promotes plant growth. Plant Physiol. 2007;143:612-6 pubmed
  5. Clark K, Larsen P, Wang X, Chang C. Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. Proc Natl Acad Sci U S A. 1998;95:5401-6 pubmed
    In Arabidopsis thaliana, signal transduction of the hormone ethylene involves at least two receptors, ETR1 and ERS, both of which are members of the two-component histidine protein kinase family that is prevalent in prokaryotes...
  6. Liu Q, Wen C. Arabidopsis ETR1 and ERS1 differentially repress the ethylene response in combination with other ethylene receptor genes. Plant Physiol. 2012;158:1193-207 pubmed publisher
    The ethylene response is negatively regulated by a family of five ethylene receptor genes in Arabidopsis (Arabidopsis thaliana)...
  7. Chen Y, Randlett M, Findell J, Schaller G. Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis. J Biol Chem. 2002;277:19861-6 pubmed
    The ethylene receptor ETR1 of Arabidopsis contains transmembrane domains responsible for ethylene binding and membrane localization...
  8. Qu X, Hall B, Gao Z, Schaller G. A strong constitutive ethylene-response phenotype conferred on Arabidopsis plants containing null mutations in the ethylene receptors ETR1 and ERS1. BMC Plant Biol. 2007;7:3 pubmed
    ..Single mutants show an ethylene response similar to wild type, although both mutants are slightly hypersensitive to ethylene...
  9. Chang C, Kwok S, Bleecker A, Meyerowitz E. Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science. 1993;262:539-44 pubmed
    ..Ethylene insensitivity is conferred by dominant mutations in the ETR1 gene early in the ethylene signal transduction pathway of Arabidopsis thaliana...
  10. Schaller G, Bleecker A. Ethylene-binding sites generated in yeast expressing the Arabidopsis ETR1 gene. Science. 1995;270:1809-11 pubmed
    Mutations in the ETR1 gene of Arabidopsis thaliana confer insensitivity to ethylene, which indicates a role for the gene product in ethylene signal transduction...
  11. Voet van Vormizeele J, Groth G. Ethylene controls autophosphorylation of the histidine kinase domain in ethylene receptor ETR1. Mol Plant. 2008;1:380-7 pubmed publisher
    ..In Arabidopsis, five ethylene receptor proteins are known, including ethylene resistant 1 (ETR1)...
  12. Gao Z, Chen Y, Randlett M, Zhao X, Findell J, Kieber J, et al. Localization of the Raf-like kinase CTR1 to the endoplasmic reticulum of Arabidopsis through participation in ethylene receptor signaling complexes. J Biol Chem. 2003;278:34725-32 pubmed
    ..eliminate ethylene receptors and by a mutation in CTR1 that reduces its ability to bind to the ethylene receptor ETR1. Direct evidence that CTR1 is part of an ethylene receptor signaling complex was obtained by co-purification of the ..
  13. Xie F, Qiu L, Wen C. Possible modulation of Arabidopsis ETR1 N-terminal signaling by CTR1. Plant Signal Behav. 2012;7:1243-5 pubmed publisher
    ..mutations of CTR1 prevent ethylene receptor signaling, and corresponding ctr1 mutants show a constitutive ethylene response phenotype...
  14. Cancel J, Larsen P. Loss-of-function mutations in the ethylene receptor ETR1 cause enhanced sensitivity and exaggerated response to ethylene in Arabidopsis. Plant Physiol. 2002;129:1557-67 pubmed
    ..Triple and quadruple loss-of-function ethylene receptor mutants display a constitutive ethylene response phenotype, indicating they function as negative regulators in this pathway...
  15. Rivarola M, McClellan C, Resnick J, Chang C. ETR1-specific mutations distinguish ETR1 from other Arabidopsis ethylene receptors as revealed by genetic interaction with RTE1. Plant Physiol. 2009;150:547-51 pubmed publisher
  16. Huang Y, Li H, Hutchison C, Laskey J, Kieber J. Biochemical and functional analysis of CTR1, a protein kinase that negatively regulates ethylene signaling in Arabidopsis. Plant J. 2003;33:221-33 pubmed
    CTR1 encodes a negative regulator of the ethylene response pathway in Arabidopsis thaliana. The C-terminal domain of CTR1 is similar to the Raf family of protein kinases, but its first two-thirds encodes a novel protein domain...
  17. Wang W, Esch J, Shiu S, Agula H, Binder B, Chang C, et al. Identification of important regions for ethylene binding and signaling in the transmembrane domain of the ETR1 ethylene receptor of Arabidopsis. Plant Cell. 2006;18:3429-42 pubmed
    The ethylene binding domain (EBD) of the Arabidopsis thaliana ETR1 receptor is modeled as three membrane-spanning helices. We surveyed ethylene binding activity in different kingdoms and performed a bioinformatic analysis of the EBD...
  18. Dong C, Rivarola M, Resnick J, Maggin B, Chang C. Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling. Plant J. 2008;53:275-86 pubmed
    ..that RTE1 expression partly correlates with previously described sites of ETR1 expression or sites of ethylene response, such as the seedling root, root hairs and apical hook...
  19. Rodriguez F, Esch J, Hall A, Binder B, Schaller G, Bleecker A. A copper cofactor for the ethylene receptor ETR1 from Arabidopsis. Science. 1999;283:996-8 pubmed
    The ETR1 receptor from Arabidopsis binds the gaseous hormone ethylene. A copper ion associated with the ethylene-binding domain is required for high-affinity ethylene-binding activity...
  20. Hua J, Meyerowitz E. Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana. Cell. 1998;94:261-71 pubmed
    ..had constitutive ethylene responses, revealing that these proteins negatively regulate ethylene responses and that the induction of ethylene response in Arabidopsis is through inactivation rather than activation of these proteins.
  21. Binder B, O Malley R, Wang W, Zutz T, Bleecker A. Ethylene stimulates nutations that are dependent on the ETR1 receptor. Plant Physiol. 2006;142:1690-700 pubmed
    ..Ethylene-stimulated nutations were also eliminated in etr1-7 loss-of-function mutants...
  22. Hall A, Bleecker A. Analysis of combinatorial loss-of-function mutants in the Arabidopsis ethylene receptors reveals that the ers1 etr1 double mutant has severe developmental defects that are EIN2 dependent. Plant Cell. 2003;15:2032-41 pubmed
    ..On the other hand, light-grown seedlings and adult ers1 etr1 double mutants exhibited severe phenotypes such as miniature rosette size, delayed flowering, and sterility, ..
  23. Moussatche P, Klee H. Autophosphorylation activity of the Arabidopsis ethylene receptor multigene family. J Biol Chem. 2004;279:48734-41 pubmed
    ..It has been previously shown that a subfamily 1 Arabidopsis thaliana ethylene receptor, ETR1, autophosphorylates in vitro on a conserved histidine residue (1)...
  24. Dong C, Jang M, Scharein B, Malach A, Rivarola M, Liesch J, et al. Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling, RTE1. J Biol Chem. 2010;285:40706-13 pubmed publisher
    ..Genetic analyses in Arabidopsis thaliana suggest that RTE1 promotes the signaling state of the ethylene receptor ETR1 through the ETR1 N-terminal domain...
  25. Wang W, Hall A, O Malley R, Bleecker A. Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission. Proc Natl Acad Sci U S A. 2003;100:352-7 pubmed
    ..The double mutants exhibited a severe constitutive ethylene response phenotype consistent with the negative regulator model for receptor function...
  26. Zhao X, Qu X, Mathews D, Schaller G. Effect of ethylene pathway mutations upon expression of the ethylene receptor ETR1 from Arabidopsis. Plant Physiol. 2002;130:1983-91 pubmed
    ..backgrounds containing receptor loss-of-function mutations, ethylene-insensitive mutations, and constitutive ethylene response mutations...
  27. O Malley R, Rodriguez F, Esch J, Binder B, O Donnell P, Klee H, et al. Ethylene-binding activity, gene expression levels, and receptor system output for ethylene receptor family members from Arabidopsis and tomato. Plant J. 2005;41:651-9 pubmed
  28. Qu X, Schaller G. Requirement of the histidine kinase domain for signal transduction by the ethylene receptor ETR1. Plant Physiol. 2004;136:2961-70 pubmed
    In Arabidopsis, ethylene is perceived by a receptor family consisting of five members, one of these being ETR1. The N-terminal half of ETR1 functions as a signal input domain...
  29. Urao T, Miyata S, Yamaguchi Shinozaki K, Shinozaki K. Possible His to Asp phosphorelay signaling in an Arabidopsis two-component system. FEBS Lett. 2000;478:227-32 pubmed
    ..We detected interactions between ETR1 and all ATHPs, and between CKI1 and ATHP1 or ATHP2. Interestingly, ERS1 could not interact with any ATHPs...
  30. Grefen C, Städele K, Ruzicka K, Obrdlik P, Harter K, Horak J. Subcellular localization and in vivo interactions of the Arabidopsis thaliana ethylene receptor family members. Mol Plant. 2008;1:308-20 pubmed publisher
    ..Our findings may have crucial functional implications on the ethylene receptor-mediated efficiency of hormone perception, induction of signaling, signal attenuation and output. ..
  31. Resnick J, Rivarola M, Chang C. Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis. Plant J. 2008;56:423-31 pubmed publisher
    ..a novel gene conserved in plants, animals and some protists, was recently identified as a positive regulator of the ETR1 ethylene receptor...
  32. Gao Z, Wen C, Binder B, Chen Y, Chang J, Chiang Y, et al. Heteromeric interactions among ethylene receptors mediate signaling in Arabidopsis. J Biol Chem. 2008;283:23801-10 pubmed publisher
    ..ethylene is perceived in Arabidopsis by a five member receptor family that consists of the subfamily 1 receptors ETR1 and ERS1 and the subfamily 2 receptors ETR2, ERS2, and EIN4...
  33. Qiu L, Xie F, Yu J, Wen C. Arabidopsis RTE1 is essential to ethylene receptor ETR1 amino-terminal signaling independent of CTR1. Plant Physiol. 2012;159:1263-76 pubmed publisher
    ..prevented ethylene receptor signaling, and the CTR1????? overexpressor CTR1-Nox showed a constitutive ethylene response phenotype. Expression of the ETR1 N terminus suppressed the CTR1-Nox phenotype...
  34. Schaller G, Ladd A, Lanahan M, Spanbauer J, Bleecker A. The ethylene response mediator ETR1 from Arabidopsis forms a disulfide-linked dimer. J Biol Chem. 1995;270:12526-30 pubmed
    Mutations in the ETR1 gene of the higher plant Arabidopsis confer insensitivity to ethylene, indicating a role for the gene product in ethylene signal perception and transduction...
  35. Gallie D. Regulated ethylene insensitivity through the inducible expression of the Arabidopsis etr1-1 mutant ethylene receptor in tomato. Plant Physiol. 2010;152:1928-39 pubmed publisher
    ..One such mutant, ethylene resistant1-1 (etr1-1), results in a strong ethylene-insensitive phenotype in Arabidopsis...
  36. Pantelides I, Tjamos S, Paplomatas E. Ethylene perception via ETR1 is required in Arabidopsis infection by Verticillium dahliae. Mol Plant Pathol. 2010;11:191-202 pubmed publisher
    ..Analysis of the mutant responses revealed enhanced resistance in etr1-1[ethylene (ET) receptor mutant] plants, but not in salicylic acid-, jasmonic acid- or other ET-deficient mutants, ..
  37. Chang J, Clay J, Chang C. Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis. Plant J. 2014;77:558-67 pubmed
    ..by RTE1 over-expression, and genetic analyses suggested that AtCb5–D acts upstream of RTE1 in the ethylene response. These findings suggest an unexpected role for Cb5, in which Cb5 and RTE1 are functional partners in ..
  38. Deslauriers S, Alvarez A, Lacey R, Binder B, Larsen P. Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis. New Phytol. 2015;208:442-55 pubmed publisher
    ..to the previously described etr1-2 mutation in the other Arabidopsis subfamily I ethylene receptor, ETHYLENE RESPONSE 1 (ETR1)...
  39. Binder B, Rodriguez F, Bleecker A. The copper transporter RAN1 is essential for biogenesis of ethylene receptors in Arabidopsis. J Biol Chem. 2010;285:37263-70 pubmed publisher
    ..In Arabidopsis thaliana, a small family of five receptor proteins typified by ETR1 mediates ethylene perception. Our previous work suggested that copper ions likely play a role in ethylene binding...
  40. Scharein B, Voet van Vormizeele J, Harter K, Groth G. Ethylene signaling: identification of a putative ETR1-AHP1 phosphorelay complex by fluorescence spectroscopy. Anal Biochem. 2008;377:72-6 pubmed publisher
    The plant ethylene receptor ETR1, which shows substantial sequence homology to typical bacterial histidine kinases, is involved in the coordination of several growth and development processes...
  41. Zhao X, Schaller G. Effect of salt and osmotic stress upon expression of the ethylene receptor ETR1 in Arabidopsis thaliana. FEBS Lett. 2004;562:189-92 pubmed
    ..Here we report that exposure of Arabidopsis plants to NaCl reduced expression of the ethylene receptor ETR1. The change in gene expression was reflected at the protein level based on immunoblot analysis...
  42. Mewis I, Appel H, Hom A, Raina R, Schultz J. Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects. Plant Physiol. 2005;138:1149-62 pubmed
    ..There was no significant impact on constitutive GS contents of blocking ET signaling (at ET resistant [etr1]) or reducing SA concentrations (nahG transgene)...
  43. Mersmann S, Bourdais G, Rietz S, Robatzek S. Ethylene signaling regulates accumulation of the FLS2 receptor and is required for the oxidative burst contributing to plant immunity. Plant Physiol. 2010;154:391-400 pubmed publisher
    ..Flagellin Sensitive2 (FLS2) accumulation was reduced in etr1 and ein2, indicating a requirement of ethylene signaling for FLS2 expression...
  44. Bisson M, Groth G. New insight in ethylene signaling: autokinase activity of ETR1 modulates the interaction of receptors and EIN2. Mol Plant. 2010;3:882-9 pubmed publisher
    ..an ethylene agonist, which is known to reduce auto-phosphorylation of the ethylene receptor ethylene resistant 1 (ETR1) or a mutation in the kinase domain of ETR1 that prevents auto-phosphorylation (H353A), increases the affinity of ..
  45. Hung Y, Jiang I, Lee Y, Wen C, Sue S. NMR Study Reveals the Receiver Domain of Arabidopsis ETHYLENE RESPONSE1 Ethylene Receptor as an Atypical Type Response Regulator. PLoS ONE. 2016;11:e0160598 pubmed publisher
    ..ETHYLENE RESPONSE1 (ETR1) is an ethylene receptor isolated from Arabidopsis and has a structure characteristic of prokaryotic two-component ..
  46. Tian Q, Sun P, Zhang W. Ethylene is involved in nitrate-dependent root growth and branching in Arabidopsis thaliana. New Phytol. 2009;184:918-31 pubmed publisher
    ..change in root development in Arabidopsis thaliana using wild types and mutants defective in ethylene signaling (etr1, ein2) and nitrate transporters (chl1, nrt2.1)...
  47. Kim H, Helmbrecht E, Stalans M, Schmitt C, Patel N, Wen C, et al. Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings. Plant Physiol. 2011;156:417-29 pubmed publisher
    ..We found that ETHYLENE RECEPTOR1 (ETR1) is both necessary and sufficient for nutations...
  48. Meldau D, Meldau S, Hoang L, Underberg S, Wünsche H, Baldwin I. Dimethyl disulfide produced by the naturally associated bacterium bacillus sp B55 promotes Nicotiana attenuata growth by enhancing sulfur nutrition. Plant Cell. 2013;25:2731-47 pubmed publisher
    ..promotes growth and survival of wild-type and, particularly, ethylene (ET)-insensitive (35)S-ethylene response1 (etr1) N. attenuata plants, which heterologously express the mutant Arabidopsis thaliana receptor ETR1-1...
  49. Xu C, Zhou X, Wen C. HYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis. PLoS Genet. 2015;11:e1004956 pubmed publisher
    ..by the hpr1-5 mutation, which indicates selectivity of HPR1 for RTE1 expression affecting the consequent ethylene response. Thus, components of the THO/TREX complex appear to have specific roles in the transcription or export of ..
  50. Mayerhofer H, Panneerselvam S, Kaljunen H, Tuukkanen A, Mertens H, Mueller Dieckmann J. Structural model of the cytosolic domain of the plant ethylene receptor 1 (ETR1). J Biol Chem. 2015;290:2644-58 pubmed publisher
    ..we report the crystallographic structures of the ethylene receptor 1 (ETR1) catalytic ATP-binding and the ethylene response sensor 1 dimerization histidine phosphotransfer (DHp) domains and the solution structure of the entire ..
  51. Desikan R, Hancock J, Bright J, Harrison J, Weir I, Hooley R, et al. A role for ETR1 in hydrogen peroxide signaling in stomatal guard cells. Plant Physiol. 2005;137:831-4 pubmed
  52. Warpeha K, Lateef S, Lapik Y, Anderson M, Lee B, Kaufman L. G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis. Plant Physiol. 2006;140:844-55 pubmed
    ..An additional outcome of the work is the confirmation that phenylpyruvate acts as the intermediate in the synthesis of Phe in etiolated plants, as it commonly does in bacteria and fungi. ..
  53. Leon P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003;8:110-6 pubmed
    ..The effects of sugar and osmotic stress on morphogenesis and gene expression are distinct. The plasticity of plant growth and development are exemplified by the complex interplay of sugar and hormone signalling. ..
  54. Loomis W, Shaulsky G, Wang N. Histidine kinases in signal transduction pathways of eukaryotes. J Cell Sci. 1997;110 ( Pt 10):1141-5 pubmed
    ..Such signal transduction pathways can be expected to be found in a variety of eukaryotic differentiations since they are rapidly reversible and can integrate disparate signals. ..
  55. Hall B, Shakeel S, Amir M, Ul Haq N, Qu X, Schaller G. Histidine kinase activity of the ethylene receptor ETR1 facilitates the ethylene response in Arabidopsis. Plant Physiol. 2012;159:682-95 pubmed publisher
    ..Subfamily 1 members ETHYLENE RESPONSE1 (ETR1) and ETHYLENE RESPONSE SENSOR1 (ERS1) have histidine kinase activity, unlike the subfamily 2 members ETR2, ERS2, and ETHYLENE ..
  56. Pajerowska K, Parker J, Gebhardt C. Potato homologs of Arabidopsis thaliana genes functional in defense signaling--identification, genetic mapping, and molecular cloning. Mol Plant Microbe Interact. 2005;18:1107-19 pubmed
    ..Our results form the basis for further studies on the contributions of these candidate genes to natural variation of potato disease resistance. ..
  57. Desikan R, Last K, Harrett Williams R, Tagliavia C, Harter K, Hooley R, et al. Ethylene-induced stomatal closure in Arabidopsis occurs via AtrbohF-mediated hydrogen peroxide synthesis. Plant J. 2006;47:907-16 pubmed
    ..Ethylene-induced closure is inhibited by the ethylene antagonists 1-MCP and silver. The ethylene receptor mutants etr1-1 and etr1-3 are insensitive to ethylene in terms of stomatal closure and H(2)O(2) production...
  58. Cela J, Falk J, Munné Bosch S. Ethylene signaling may be involved in the regulation of tocopherol biosynthesis in Arabidopsis thaliana. FEBS Lett. 2009;583:992-6 pubmed publisher
    Tocopherol biosynthesis was investigated in ein3-1, etr1-1 and eto1-1 mutants of Arabidopsis thaliana, which show a defect in ethylene signaling, perception and over-produce ethylene, respectively...
  59. Bisson M, Bleckmann A, Allekotte S, Groth G. EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1. Biochem J. 2009;424:1-6 pubmed publisher
    ..Here we show, by an integrated approach using in vivo and in vitro fluorescence techniques, that EIN2 is localized at the ER (endoplasmic reticulum) membrane where it shows specific interaction with the ethylene receptor protein ETR1.
  60. Cho Y, Kim G, Yoo S. Giant chloroplast development in ethylene response1-1 is caused by a second mutation in ACCUMULATION AND REPLICATION OF CHLOROPLAST3 in Arabidopsis. Mol Cells. 2012;33:99-103 pubmed publisher
    ..Here, we described an abnormal chloroplast phenotype in an ethylene insensitive ethylene response1-1 (etr1-1) of Arabidopsis thaliana...
  61. Clay N, Adio A, Denoux C, Jander G, Ausubel F. Glucosinolate metabolites required for an Arabidopsis innate immune response. Science. 2009;323:95-101 pubmed publisher
    ..Our study shows that well-studied plant metabolites, previously identified as important in avoiding damage by herbivores, are also required as a component of the plant defense response against microbial pathogens...
  62. Ge X, Cai H, Lei X, Zhou X, Yue M, He J. Heterotrimeric G protein mediates ethylene-induced stomatal closure via hydrogen peroxide synthesis in Arabidopsis. Plant J. 2015;82:138-50 pubmed publisher
    ..Ethylene-triggered H2O2 generation and stomatal closure were impaired in RAN1, ETR1, ERS1 and EIN4 mutants but not impaired in ETR2 and ERS2 mutants...
  63. Etchells J, Provost C, Turner S. Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling. PLoS Genet. 2012;8:e1002997 pubmed publisher
    ..We propose a model whereby vascular cell division is regulated both by PXY signalling and ethylene/ERF signalling. Under normal circumstances, however, PXY signalling acts to repress the ethylene/ERF pathway. ..
  64. Mayerhofer H, Panneerselvam S, Mueller Dieckmann J. Protein kinase domain of CTR1 from Arabidopsis thaliana promotes ethylene receptor cross talk. J Mol Biol. 2012;415:768-79 pubmed publisher
    ..This model provides a structural foundation for the observed high sensitivity of plants to ethylene. ..
  65. Lapik Y, Kaufman L. The Arabidopsis cupin domain protein AtPirin1 interacts with the G protein alpha-subunit GPA1 and regulates seed germination and early seedling development. Plant Cell. 2003;15:1578-90 pubmed
    ..These data indicate that AtPirin1 likely functions immediately downstream of GPA1 in regulating seed germination and early seedling development. ..
  66. Bakshi A, Wilson R, Lacey R, Kim H, Wuppalapati S, Binder B. Identification of Regions in the Receiver Domain of the ETHYLENE RESPONSE1 Ethylene Receptor of Arabidopsis Important for Functional Divergence. Plant Physiol. 2015;169:219-32 pubmed publisher
    ..However, the ETHYLENE RESPONSE1 (ETR1) ethylene receptor has unique, and sometimes contrasting, roles from the other receptor isoforms...
  67. Larkindale J, Hall J, Knight M, Vierling E. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Plant Physiol. 2005;138:882-97 pubmed
    ..Ethylene signaling mutants (ein2 and etr1) and reactive oxygen metabolism mutants (vtc1, vtc2, npq1, and cad2) were more defective in basal than acquired ..
  68. Wang Q, Zhang W, Yin Z, Wen C. Rice CONSTITUTIVE TRIPLE-RESPONSE2 is involved in the ethylene-receptor signalling and regulation of various aspects of rice growth and development. J Exp Bot. 2013;64:4863-75 pubmed publisher
    ..Arabidopsis ethylene receptors ETHYLENE RESPONSE1 and ETHYLENE RESPONSE SENSOR1 physically interacted with OsCTR2 on yeast two-hybrid assay, and green fluorescence protein-tagged ..