Gene Symbol: ERF4
Description: ethylene responsive element binding factor 4
Alias: ATERF-4, ATERF4, ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 4, RAP2.5, RELATED TO AP2 5, ethylene responsive element binding factor 4, ethylene responsive element binding factor 4
Species: thale cress

Top Publications

  1. Ohta M, Matsui K, Hiratsu K, Shinshi H, Ohme Takagi M. Repression domains of class II ERF transcriptional repressors share an essential motif for active repression. Plant Cell. 2001;13:1959-68 pubmed
    We reported previously that three ERF transcription factors, tobacco ERF3 (NtERF3) and Arabidopsis AtERF3 and AtERF4, which are categorized as class II ERFs, are active repressors of transcription...
  2. Song C, Galbraith D. AtSAP18, an orthologue of human SAP18, is involved in the regulation of salt stress and mediates transcriptional repression in Arabidopsis. Plant Mol Biol. 2006;60:241-57 pubmed
  3. Chen L, Lee J, Weber H, Tohge T, Witt S, Roje S, et al. Arabidopsis BPM proteins function as substrate adaptors to a cullin3-based E3 ligase to affect fatty acid metabolism in plants. Plant Cell. 2013;25:2253-64 pubmed publisher
    ..Overall, this work demonstrates a link between fatty acid metabolism and E3 ligase activities in plants and establishes CUL3-based E3 ligases as key regulators in transcriptional processes that involve ERF/AP2 family members. ..
  4. Yang Z, Tian L, Latoszek Green M, Brown D, Wu K. Arabidopsis ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic acid responses. Plant Mol Biol. 2005;58:585-96 pubmed
    ..The Arabidopsis genome contains eight ERF repressors, namely AtERF3, AtERF4, and AtERF7 to AtERF12...
  5. Yang S, Wang S, Liu X, Yu Y, Yue L, Wang X, et al. Four divergent Arabidopsis ethylene-responsive element-binding factor domains bind to a target DNA motif with a universal CG step core recognition and different flanking bases preference. FEBS J. 2009;276:7177-86 pubmed publisher
    ..AtERF1, AtERF4, AtEBP and CBF1 are members from different phylogenetic subgroups within the family...
  6. Koyama T, Nii H, Mitsuda N, Ohta M, Kitajima S, Ohme Takagi M, et al. A regulatory cascade involving class II ETHYLENE RESPONSE FACTOR transcriptional repressors operates in the progression of leaf senescence. Plant Physiol. 2013;162:991-1005 pubmed publisher
    ..Furthermore, NtERF3 accumulated in plants treated with a proteasome inhibitor. The Arabidopsis class II ERFs AtERF4 and AtERF8 were also regulated by the proteasome and increased with plant aging...
  7. Fujimoto S, Ohta M, Usui A, Shinshi H, Ohme Takagi M. Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. Plant Cell. 2000;12:393-404 pubmed
    ..By contrast, AtERF3 and AtERF4 acted as repressors that downregulated not only basal transcription levels of a reporter gene but also the ..
  8. McGrath K, Dombrecht B, Manners J, Schenk P, Edgar C, Maclean D, et al. Repressor- and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression. Plant Physiol. 2005;139:949-59 pubmed
    ..Functional analysis of the B1a TF AtERF4 revealed that AtERF4 acts as a novel negative regulator of JA-responsive defense gene expression and resistance to ..
  9. Zhu Y, Schluttenhoffer C, Wang P, Fu F, Thimmapuram J, Zhu J, et al. CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis. Plant Cell. 2014;26:4149-70 pubmed publisher
    ..cinerea. ..

More Information


  1. Liu W, Karemera N, Wu T, Yang Y, Zhang X, Xu X, et al. The ethylene response factor AtERF4 negatively regulates the iron deficiency response in Arabidopsis thaliana. PLoS ONE. 2017;12:e0186580 pubmed publisher
    ..Thus, this study aimed to investigate the role of AtERF4 in plant responses to Fe deficiency...