EIN3

Summary

Gene Symbol: EIN3
Description: Ethylene insensitive 3 family protein
Alias: AtEIN3, ETHYLENE-INSENSITIVE3, Ethylene insensitive 3 family protein
Species: thale cress

Top Publications

  1. Binder B, Mortimore L, Stepanova A, Ecker J, Bleecker A. Short-term growth responses to ethylene in Arabidopsis seedlings are EIN3/EIL1 independent. Plant Physiol. 2004;136:2921-7 pubmed
    ..is required for both the first and second phases of growth inhibition by ethylene, while the transcription factors EIN3 and EIL1 are required for the second phase but not the first phase. The first phase lasts no more than 2 h...
  2. Chao Q, Rothenberg M, Solano R, Roman G, Terzaghi W, Ecker J. Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins. Cell. 1997;89:1133-44 pubmed
    Mutations in the Arabidopsis ETHYLENE-INSENSITIVE3 (EIN3) gene severely limit a plant's response to the gaseous hormone ethylene...
  3. Chang K, Zhong S, Weirauch M, Hon G, Pelizzola M, Li H, et al. Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. elife. 2013;2:e00675 pubmed publisher
    ..transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ..
  4. An F, Zhao Q, Ji Y, Li W, Jiang Z, Yu X, et al. Ethylene-induced stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 is mediated by proteasomal degradation of EIN3 binding F-box 1 and 2 that requires EIN2 in Arabidopsis. Plant Cell. 2010;22:2384-401 pubmed publisher
    Plant responses to ethylene are mediated by regulation of EBF1/2-dependent degradation of the ETHYLENE INSENSITIVE3 (EIN3) transcription factor...
  5. Solano R, Stepanova A, Chao Q, Ecker J. Nuclear events in ethylene signaling: a transcriptional cascade mediated by ETHYLENE-INSENSITIVE3 and ETHYLENE-RESPONSE-FACTOR1. Genes Dev. 1998;12:3703-14 pubmed
    Response to the gaseous plant hormone ethylene in Arabidopsis requires the EIN3/EIL family of nuclear proteins. The biochemical function(s) of EIN3/EIL proteins, however, has remained unknown...
  6. Potuschak T, Lechner E, Parmentier Y, Yanagisawa S, Grava S, Koncz C, et al. EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. Cell. 2003;115:679-89 pubmed
    ..with ethylene binding at a family of ethylene receptors and terminates in a transcription cascade involving the EIN3/EIL and ERF families of plant-specific transcription factors...
  7. Zhang L, Li Z, Quan R, Li G, Wang R, Huang R. An AP2 domain-containing gene, ESE1, targeted by the ethylene signaling component EIN3 is important for the salt response in Arabidopsis. Plant Physiol. 2011;157:854-65 pubmed publisher
    ..ERF) genes enhances salt tolerance; however, transcriptional regulation of the ethylene signal component ETHYLENE INSENSITIVE3 (EIN3) in the salt response has not been clearly defined...
  8. Konishi M, Yanagisawa S. Ethylene signaling in Arabidopsis involves feedback regulation via the elaborate control of EBF2 expression by EIN3. Plant J. 2008;55:821-31 pubmed publisher
    b>EIN3 is a key transcription factor in the signaling pathway of the plant hormone ethylene in Arabidopsis...
  9. Chen H, Xue L, Chintamanani S, Germain H, Lin H, Cui H, et al. ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 repress SALICYLIC ACID INDUCTION DEFICIENT2 expression to negatively regulate plant innate immunity in Arabidopsis. Plant Cell. 2009;21:2527-40 pubmed publisher
    ..Here, we show that Arabidopsis thaliana transcription factors ETHYLENE INSENSITIVE3 (EIN3) and ETHYLENE INSENSITIVE3-LIKE1 (EIL1), previously known to mediate ethylene signaling, also ..

More Information

Publications41

  1. Lingam S, Mohrbacher J, Brumbarova T, Potuschak T, Fink Straube C, Blondet E, et al. Interaction between the bHLH transcription factor FIT and ETHYLENE INSENSITIVE3/ETHYLENE INSENSITIVE3-LIKE1 reveals molecular linkage between the regulation of iron acquisition and ethylene signaling in Arabidopsis. Plant Cell. 2011;23:1815-29 pubmed publisher
    ..Here, we demonstrate a direct molecular link between ethylene signaling and FIT. We identified ETHYLENE INSENSITIVE3 (EIN3) and ETHYLENE INSENSITIVE3-LIKE1 (EIL1) in a screen for direct FIT interaction partners and ..
  2. Li Z, Peng J, Wen X, Guo H. Ethylene-insensitive3 is a senescence-associated gene that accelerates age-dependent leaf senescence by directly repressing miR164 transcription in Arabidopsis. Plant Cell. 2013;25:3311-28 pubmed publisher
    ..Here, we examine ethylene-insensitive3 (EIN3), a key transcription factor in ethylene signaling, and find that EIN3 is a functional senescence-associated gene...
  3. Alonso J, Stepanova A, Solano R, Wisman E, Ferrari S, Ausubel F, et al. Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis. Proc Natl Acad Sci U S A. 2003;100:2992-7 pubmed
    ..from a mutation in the ethylene receptor ERS, whereas wei5, a semidominant mutant, was caused by a mutation in the EIN3-related transcription factor gene EIL1...
  4. Zhu Z, An F, Feng Y, Li P, Xue L, A M, et al. Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis. Proc Natl Acad Sci U S A. 2011;108:12539-44 pubmed publisher
    ..Here, we report that two Arabidopsis ET-stabilized transcription factors (EIN3 and EIL1) integrate ET and JA signaling in the regulation of gene expression, root development, and necrotrophic ..
  5. Gagne J, Smalle J, Gingerich D, Walker J, Yoo S, Yanagisawa S, et al. Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation. Proc Natl Acad Sci U S A. 2004;101:6803-8 pubmed
    ..EBF1 and -2 interact directly with ethylene insensitive 3 (EIN3), a transcriptional regulator important for ethylene signaling...
  6. Guo H, Ecker J. Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. Cell. 2003;115:667-77 pubmed
    Plants use ethylene gas as a signal to regulate myriad developmental processes and stress responses. The Arabidopsis EIN3 protein is a key transcription factor mediating ethylene-regulated gene expression and morphological responses...
  7. Sun J, Ma Q, Mao T. Ethylene Regulates the Arabidopsis Microtubule-Associated Protein WAVE-DAMPENED2-LIKE5 in Etiolated Hypocotyl Elongation. Plant Physiol. 2015;169:325-37 pubmed publisher
    ..This study reveals a mechanism involved in the ethylene regulation of microtubules through WDL5 to inhibit etiolated hypocotyl cell elongation. ..
  8. Zhang F, Qi B, Wang L, Zhao B, Rode S, Riggan N, et al. EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling. Nat Commun. 2016;7:13018 pubmed publisher
    ..Both EIN2 and EIN3 interact with a SANT domain protein named EIN2 nuclear associated protein 1 (ENAP1), overexpression of which ..
  9. Asensi Fabado M, Cela J, Müller M, Arrom L, Chang C, Munné Bosch S. Enhanced oxidative stress in the ethylene-insensitive (ein3-1) mutant of Arabidopsis thaliana exposed to salt stress. J Plant Physiol. 2012;169:360-8 pubmed publisher
    ..Among the genes analyzed, EIN3 showed the highest expression level increase under salt stress, suggesting a key role for this ethylene-signaling ..
  10. Song J, Zhu C, Zhang X, Wen X, Liu L, Peng J, et al. Biochemical and Structural Insights into the Mechanism of DNA Recognition by Arabidopsis ETHYLENE INSENSITIVE3. PLoS ONE. 2015;10:e0137439 pubmed publisher
    ..responses and developmental adaptations in plants by controlling gene expression via transcription factors ETHYLENE INSENSITIVE3 (EIN3) and EIN3-Like1 (EIL1)...
  11. Peng J, Li Z, Wen X, Li W, Shi H, Yang L, et al. Salt-induced stabilization of EIN3/EIL1 confers salinity tolerance by deterring ROS accumulation in Arabidopsis. PLoS Genet. 2014;10:e1004664 pubmed publisher
    ..Gain- and loss-of-function studies demonstrated that EIN3 (ETHYLENE INSENSITIVE 3) and EIL1 (EIN3-LIKE 1), two ethylene-activated transcription factors, are necessary and ..
  12. Qiu K, Li Z, Yang Z, Chen J, Wu S, Zhu X, et al. EIN3 and ORE1 Accelerate Degreening during Ethylene-Mediated Leaf Senescence by Directly Activating Chlorophyll Catabolic Genes in Arabidopsis. PLoS Genet. 2015;11:e1005399 pubmed publisher
    ..b>ETHYLENE INSENSITIVE3 (EIN3) is a key transcription factor in the ethylene signaling pathway...
  13. Liang X, Wang H, Mao L, Hu Y, Dong T, Zhang Y, et al. Involvement of COP1 in ethylene- and light-regulated hypocotyl elongation. Planta. 2012;236:1791-802 pubmed publisher
    ..ETHYLENE-INSENSITIVE3 (EIN3, an ethylene-stabilized transcription factor) directly regulates ETHYLENE-RESPONSE-FACTOR1 (ERF1)...
  14. Xie L, Yu L, Chen Q, Wang F, Huang L, Xia F, et al. Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism. Plant J. 2015;81:53-67 pubmed publisher
    ..By analyses of double combinations of OE-1 with npr1-5, coi1-2, ein3-1 as well as ctr1-1 mutants, we observed that the attenuated hypoxic tolerance in ACBP3-OEs was dependent on NPR1- ..
  15. Song S, Huang H, Gao H, Wang J, Wu D, Liu X, et al. Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis. Plant Cell. 2014;26:263-79 pubmed publisher
    ..the JA-activated transcription factor MYC2 and the ET-stabilized transcription factor ETHYLENE-INSENSITIVE3 (EIN3) modulates JA and ET signaling antagonism in Arabidopsis thaliana...
  16. Cela J, Falk J, Munné Bosch S. Ethylene signaling may be involved in the regulation of tocopherol biosynthesis in Arabidopsis thaliana. FEBS Lett. 2009;583:992-6 pubmed publisher
    Tocopherol biosynthesis was investigated in ein3-1, etr1-1 and eto1-1 mutants of Arabidopsis thaliana, which show a defect in ethylene signaling, perception and over-produce ethylene, respectively...
  17. Zhang X, Zhu Z, An F, Hao D, Li P, Song J, et al. Jasmonate-activated MYC2 represses ETHYLENE INSENSITIVE3 activity to antagonize ethylene-promoted apical hook formation in Arabidopsis. Plant Cell. 2014;26:1105-17 pubmed publisher
    ..of hook development and a direct target gene of the ethylene (ET)-activated transcription factors ETHYLENE INSENSITIVE3 (EIN3) and its close homolog EIN3-Like1...
  18. Yoo S, Cho Y, Tena G, Xiong Y, Sheen J. Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature. 2008;451:789-95 pubmed publisher
    ..genetic screens, here we uncover a previously unexpected MKK9-MPK3/MPK6 cascade promoting ethylene-insensitive 3 (EIN3)-mediated transcription in ethylene signalling...
  19. Zhong S, Shi H, Xue C, Wang L, Xi Y, Li J, et al. A molecular framework of light-controlled phytohormone action in Arabidopsis. Curr Biol. 2012;22:1530-5 pubmed publisher
    ..transcription factor phytochrome-interacting factor 3 (PIF3) is directly activated by ETHYLENE-INSENSITIVE 3 (EIN3) and is indispensible for ethylene-induced hypocotyl elongation in light...
  20. Kang G, Son S, Cho Y, Yoo S. Regulatory role of BOTRYTIS INDUCED KINASE1 in ETHYLENE INSENSITIVE3-dependent gene expression in Arabidopsis. Plant Cell Rep. 2015;34:1605-14 pubmed publisher
    ..The loss of function BIK1 becomes insensitive to ethylene, but it still accumulates a higher level of ETHYLENE INSENSITIVE3 (EIN3) that serves as the key transcription activator in ethylene signaling...
  21. Liu G, Gao S, Tian H, Wu W, Robert H, Ding Z. Local Transcriptional Control of YUCCA Regulates Auxin Promoted Root-Growth Inhibition in Response to Aluminium Stress in Arabidopsis. PLoS Genet. 2016;12:e1006360 pubmed publisher
    ..Moreover, ethylene-insensitive 3 (EIN3) is involved into the direct regulation of YUC9 transcription in this process...
  22. He X, Jiang J, Wang C, Dehesh K. ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression. J Integr Plant Biol. 2017;59:275-287 pubmed publisher
    ..Here, we show the opposing function of two transcription factors, ethylene insensitive3 (EIN3) and EIN3-Like1 (EIL1), in SA-mediated suppression and JA-mediated activation of PLANT DEFENSIN1...
  23. Bauer P, Blondet E. Transcriptome analysis of ein3 eil1 mutants in response to iron deficiency. Plant Signal Behav. 2011;6:1669-71 pubmed publisher
    ..Recently, we identified the ethylene-regulated transcription factors ETHYLENE INSENSITIVE3 (EIN3) and EIN3-LIKE1 (EIL1) as protein interaction partners of the Fe deficiency response regulator and ..
  24. Binder B, Walker J, Gagne J, Emborg T, Hemmann G, Bleecker A, et al. The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling. Plant Cell. 2007;19:509-23 pubmed
    Ethylene signaling in Arabidopsis thaliana converges on the ETHYLENE-INSENSITIVE3 (EIN3)/EIN3-Like (EIL) transcription factors to induce various responses...
  25. Lee J, Deng X, Kim W. Possible role of light in the maintenance of EIN3/EIL1 stability in Arabidopsis seedlings. Biochem Biophys Res Commun. 2006;350:484-91 pubmed
    To examine the mechanism of EIN3-mediated gene expression by ethylene, the expression patterns of ethylene-inducible genes by ethylene were monitored in Col-0 and ethylene signaling mutants...
  26. Leon P, Sheen J. Sugar and hormone connections. Trends Plant Sci. 2003;8:110-6 pubmed
    ..The effects of sugar and osmotic stress on morphogenesis and gene expression are distinct. The plasticity of plant growth and development are exemplified by the complex interplay of sugar and hormone signalling. ..
  27. Nie H, Zhao C, Wu G, Wu Y, Chen Y, Tang D. SR1, a calmodulin-binding transcription factor, modulates plant defense and ethylene-induced senescence by directly regulating NDR1 and EIN3. Plant Physiol. 2012;158:1847-59 pubmed publisher
    ..In addition, we show that SR1 regulates ethylene-induced senescence by directly binding to the ETHYLENE INSENSITIVE3 (EIN3) promoter region in vivo. Enhanced ethylene-induced senescence in sr1-1 is suppressed by ein3...
  28. Shi H, Shen X, Liu R, Xue C, Wei N, Deng X, et al. The Red Light Receptor Phytochrome B Directly Enhances Substrate-E3 Ligase Interactions to Attenuate Ethylene Responses. Dev Cell. 2016;39:597-610 pubmed publisher
    ..Here, we report that light activation of photoreceptor phyB results in rapid degradation of EIN3, the master transcription factor in the ethylene signaling pathway...
  29. Yang Y, Ou B, Zhang J, Si W, Gu H, Qin G, et al. The Arabidopsis Mediator subunit MED16 regulates iron homeostasis by associating with EIN3/EIL1 through subunit MED25. Plant J. 2014;77:838-51 pubmed publisher
    ..MED25 played an important role in regulation of iron homeostasis by interacting with EIN3 and EIL1, two transcription factors in ethylene signaling associated with regulation of iron homeostasis...
  30. Zhang Y, Liu J, Chai J, Xing D. Mitogen-activated protein kinase 6 mediates nuclear translocation of ORE3 to promote ORE9 gene expression in methyl jasmonate-induced leaf senescence. J Exp Bot. 2016;67:83-94 pubmed publisher
    ..Nuclear CEND accumulated ETHYLENE INSENSITIVE3 (EIN3), a transcription factor that accelerates MeJA-induced leaf senescence wherein ORESARA9 (ORE9) ..
  31. Wawrzynska A, Sirko A. EIN3 interferes with the sulfur deficiency signaling in Arabidopsis thaliana through direct interaction with the SLIM1 transcription factor. Plant Sci. 2016;253:50-57 pubmed publisher
    ..It belongs to the same protein family as EIN3, a major positive switch of ethylene signaling pathway. It binds to the specific cis sequence called UPE-box...
  32. Luo J, Ma N, Pei H, Chen J, Li J, Gao J. A DELLA gene, RhGAI1, is a direct target of EIN3 and mediates ethylene-regulated rose petal cell expansion via repressing the expression of RhCesA2. J Exp Bot. 2013;64:5075-84 pubmed publisher
    ..Furthermore, RhCesA2 was a direct target of RhGAI1. This work uncovers the transcriptional regulation of RhGAI1 by ethylene and provides a better understanding of how ethylene regulates petal expansion in roses. ..